Monitoring immune function during tacrolimus tapering in small bowel transplant recipients

Utility of the Cylex Assay in Cardiac Transplant Recipients

“…3 Since its approval, the Cylex assay has been used to tailor immunosuppression in transplant recipients of kidney, pancreas, small intestine, liver and heart. 1,8,9 However, the clinical data in cardiac transplant recipients are limited. 3 In this single-center study of 111 stable cardiac transplant recipients, the Cylex assay had limited utility in predicting risk of infection or rejection when used as an adjunct to routine clinical evaluation and drug-level monitoring.…”

Benefit of immune monitoring in heart transplant patients using ATP production in activated lymphocytes

“…It has shown promise in assessing infection and rejection risk in solid-organ transplants, 4 including kidney, 5,6 pancreas 7 and small bowel. 8 However, in a recent study by Gupta et al, involving 111 heart transplant patients, scores did not correlate with infection (n ϭ 7) or rejection (n ϭ 1). 9 The purpose of the current study was to investigate the utility of this IM assay in a large number of heart transplant recipients at our institution.…”

How Can We Measure Immunologic Tolerance in Humans?

“…This assay was designed to reflect the global or net state of immunosuppression and thereby facilitate decisions related to dosing immunosuppressive drugs after transplantation. To date, only a single report has described the clinical use of this assay for managing immunosuppression after transplantation (66). The broader clinical application of this assay likely will require greater experience in the setting of immunosuppressive drug weaning and tolerance.…”