Monitoring nano-flow rate of water by atomic emission detection using helium radio-frequency plasma

Nakagama, Tatsuro; Maeda, Tsuneaki; Uchiyama, Katsumi; Hobo, Toshiyuki

doi:10.1039/b300032j

Cited by 11 publications

(4 citation statements)

References 11 publications

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“…They detected copper in solution with the observation of five atomic emission lines (203). Nakagama et al reported an atomic emission detector using a helium plasma to measure the flow rate of water in the range from 4 nL‚min -1 to 1 µL‚min -1 by quantitatively detecting the emission from hydrogen in the water molecules (204). Infrared thermal velocimetry was developed by Chung and co-workers, enabling velocity measurements in transparent MEMS-based fluidic devices ranging from centimeters to meters per second (205).…”

Section: Coupling Of Separationmentioning

confidence: 99%

Micro Total Analysis Systems. Recent Developments

2004

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Section: Coupling Of Separationmentioning

confidence: 99%

Micro Total Analysis Systems. Recent Developments

2004

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“…A multitude of techniques for direct flow measurements are also offered in the literature. On-chip flow measurement techniques include particle image velocitometry (PIV), 13,14 molecular tagging velocitometry, 15 laser-induced fluorescence (LIF) time of flight (TOF), 16,17 electrical admittance, 18 bubble interface monitoring, 19,20 droplet monitoring, 21 atomic emission spectroscopy of water 22 and elastic photopolymerized microsprings. 23 These methods typically add complexity to the device and can require other expensive instrumentation.…”

Section: Introductionmentioning

confidence: 99%

A simple method for the evaluation of microfluidic architecture using flow quantitation via a multiplexed fluidic resistance measurement

et al. 2010

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Quality control of microdevices adds significant costs, in time and money, to any fabrication process. A simple, rapid quantitative method for the post-fabrication characterization of microchannel architecture using the measurement of flow with volumes relevant to microfluidics is presented. By measuring the mass of a dye solution passed through the device, it circumvents traditional gravimetric and interface-tracking methods that suffer from variable evaporation rates and the increased error associated with smaller volumes. The multiplexed fluidic resistance (MFR) measurement method measures flow via stable visible-wavelength dyes, a standard spectrophotometer and common laboratory glassware. Individual dyes are used as molecular markers of flow for individual channels, and in channel architectures where multiple channels terminate at a common reservoir, spectral deconvolution reveals the individual flow contributions. On-chip, this method was found to maintain accurate flow measurement at lower flow rates than the gravimetric approach. Multiple dyes are shown to allow for independent measurement of multiple flows on the same device simultaneously. We demonstrate that this technique is applicable for measuring the fluidic resistance, which is dependent on channel dimensions, in four fluidically connected channels simultaneously, ultimately determining that one chip was partially collapsed and, therefore, unusable for its intended purpose. This method is thus shown to be widely useful in troubleshooting microfluidic flow characteristics.

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“…Many have shown that flow metering is possible using different sensing mechanisms such as periodic flapping motion detection, 1 thermistor based temperature difference detection with varying flow rates, 2 atomic emission detection using radio RF plasma for nanoscale flow rate metering, 3 rapid scanning using a laser-induced self-mixing effect, 4 and other methods. The heat sensing mechanism works by measuring the temperature difference in a micro channel across two points.…”

Section: Introductionmentioning

confidence: 99%

Flow metering characterization within an electrical cell counting microfluidic device

et al. 2014

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Microfluidic devices based on the Coulter principle require a small aperture for cell counting. For applications using such cell counting devices, the volume of the sample also needs to be metered to determine the absolute cell count in a specific volume. Hence, integrated methods to characterize and meter the volume of a fluid are required in these microfluidic devices. Here, we present fluid flow characterization and electrically-based sample metering results of blood through a measurement channel with a cross-section of 15 μm × 15 μm (i.e. the Coulter aperture). Red blood cells in whole blood are lysed and the remaining fluid, consisting of leukocytes, erythrocyte cell lysate and various reagents, is flown at different flow rates through the measurement aperture. The change in impedance across the electrodes embedded in the counting channel shows a linear relationship with the increase in the fluid flow rate. We also show that the fluid volume can be determined by measuring the decrease in pulse width, and increase in number of cells as they pass through the counting channel per unit time.

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Monitoring nano-flow rate of water by atomic emission detection using helium radio-frequency plasma

Cited by 11 publications

References 11 publications

Micro Total Analysis Systems. Recent Developments

Micro Total Analysis Systems. Recent Developments

A simple method for the evaluation of microfluidic architecture using flow quantitation via a multiplexed fluidic resistance measurement

Flow metering characterization within an electrical cell counting microfluidic device

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