2003
DOI: 10.2754/avb200372020191
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Monitoring of Antioxidative Effect of Morine in Alloxan-induced Diabetes mellitus in the Laboratory Rat

Abstract: The purpose of the study was to monitor the antioxidative effect of morine in alloxan-induced diabetes mellitus in laboratory rat. The animals were divided by random selection into two groups (n = 7). The treated group was given morine in oral doses of 10 mg/kg -1 in 0.5% solution of Methocel E5 once a day; the control diabetic group was given only the solution of Methocel E5. Once a week, selected laboratory indices were determined in all animals (glucose, urea and cholesterol levels in serum, total glucose a… Show more

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Cited by 22 publications
(14 citation statements)
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“…20) Thus alloxan induced diabetes mellitus served as a pathological biomodel for testing a substance with supposed antioxidant activity in vivo. 21) One of the targets of the reactive oxygen species is DNA of pancreatic islets. Its fragmentation takes place in β cells exposed to alloxan.…”
Section: Resultsmentioning
confidence: 99%
“…20) Thus alloxan induced diabetes mellitus served as a pathological biomodel for testing a substance with supposed antioxidant activity in vivo. 21) One of the targets of the reactive oxygen species is DNA of pancreatic islets. Its fragmentation takes place in β cells exposed to alloxan.…”
Section: Resultsmentioning
confidence: 99%
“…A relationship between oxidative stress and diabetes mellitus has been well demonstrated in many experimental animal models Bartosikova et al, 2003).…”
Section: Discussionmentioning
confidence: 98%
“…The alloxan-induced diabetic mice had a three to four fold increase in blood relative to the normal control mice. Administration of diabetogenic drug, alloxan monohydrate, caused a selective massive destruction of the β cells of islets of Langerhans resulting in hyperglycemia [14,15]. The lowering effect of blood sugar levels by Ocimum lamiifolium in the same manner regardless of the dosage might suggest that the extract may have been absorbed in the cell system through active transport where a particular concentration saturation of the extract occurred resulting to the rest of extract being excreted [16].…”
Section: Discussionmentioning
confidence: 99%