2014
DOI: 10.2310/7290.2014.00024
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Monitoring of Biodistribution and Persistence of Conditionally Replicative Adenovirus in a Murine Model of Ovarian Cancer Using Capsid-Incorporated mCherry and Expression of Human Somatostatin Receptor Subtype 2 Gene

Abstract: A significant limiting factor to the human clinical application of conditionally replicative adenovirus (CRAd)-based virotherapy is the inability to noninvasively monitor these agents and their potential persistence. To address this issue, we proposed a novel imaging approach that combines transient expression of the human somatostatin receptor (SSTR) subtype 2 reporter gene with genetic labeling of the viral capsid with mCherry fluorescent protein. To test this dual modality system, we constructed the Ad5/3Δ2… Show more

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Cited by 6 publications
(2 citation statements)
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References 85 publications
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“…HAdV vectors are used for virotherapy and gene therapy for cancer [101,106,107,108]. The application of HAdVs for cancer therapy dates back to the 1950s when wild-type Ad was used to treat cervical cancer.…”
Section: Ad Vectors In Gene Therapymentioning
confidence: 99%
“…HAdV vectors are used for virotherapy and gene therapy for cancer [101,106,107,108]. The application of HAdVs for cancer therapy dates back to the 1950s when wild-type Ad was used to treat cervical cancer.…”
Section: Ad Vectors In Gene Therapymentioning
confidence: 99%
“…In this regard, we have previously utilized the human somatostatin receptor subtype 2 (SSTR2) for imaging of gene transfer using gamma camera imaging and PET imaging. 15 – 19 Somatostatin receptors are members of the G protein-coupled receptor (GPCR) family that have seven transmembrane domains consisting of three extracellular loops, termed E1, E2, and E3. 18 SSTR2 is expressed on brain, spleen, and kidney tissues and overexpressed in a variety of tumor types, leading to the development of tumor imaging agents.…”
Section: Introductionmentioning
confidence: 99%