2012
DOI: 10.1039/c2fo30061c
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Monitoring of biotransformation of hop aroma compounds in an in vitro digestion model

Abstract: An in vitro digestion procedure followed by gas chromatography-mass spectrometry analysis has been applied to assess the stability of aroma compounds from hop oil in the human gastrointestinal tract. Hop oil is used in phytotherapy as a sedative, yet the bioactive substances responsible for this effect have not been conclusively clarified. Therefore, the focus of this study was placed on hop aroma substances that: (i) have been previously described to possess sedative properties, (ii) are suspected to have the… Show more

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Cited by 25 publications
(41 citation statements)
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“…This process has been shown to go along with changes in smell character and intensity of specific substances (Schilling, 2017). Terpenoid substances can also undergo heavy biotransformation prior to metabolism following ingestion and passage of the gastro-intestinal tract (Heinlein and Buettner, 2012). In the gut, chemical transformation processes are primarily associated with the acidic conditions in the stomach.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This process has been shown to go along with changes in smell character and intensity of specific substances (Schilling, 2017). Terpenoid substances can also undergo heavy biotransformation prior to metabolism following ingestion and passage of the gastro-intestinal tract (Heinlein and Buettner, 2012). In the gut, chemical transformation processes are primarily associated with the acidic conditions in the stomach.…”
Section: Discussionmentioning
confidence: 99%
“…In the gut, chemical transformation processes are primarily associated with the acidic conditions in the stomach. A series of other terpenoid derivatives has been determined following these transformation pathways, e.g., linalool degraded to geraniol, nerol, and α-terpineol (Heinlein and Buettner, 2012). Accordingly, biotransformation and bioavailability are important aspects when discussing potential physiological effects of aroma substances.…”
Section: Discussionmentioning
confidence: 99%
“…Potential physiological effects in relation to food or beverages are often investigated on substances that occur naturally in the product, but potential metabolism within the body is rarely considered. In view of this, recent research has shown that volatile substances can undergo major transformation steps within the body or can be released from non-volatile precursors, e.g., in the human gastrointestinal tract [20] or during absorption processes [21], leading to compounds that were not present in the original product [22,23,24,25]. …”
Section: Introductionmentioning
confidence: 99%
“…In this context it is puzzling that odorant biotransformation during passage through the gastrointestinal tract has hitherto drawn only little attention. However, recent studies of our group show that quite pronounced chemical modulations can occur, leading not only to degradation but also to formation of odor substances [21].…”
Section: Biotransformation; In Vivo Versus In Vitromentioning
confidence: 99%