Monitoring of clobetasol propionate and betamethasone dipropionate as undeclared steroids in cosmetic products manufactured in Korea

Nam, Yun Sik; Kwon, Il Keun; Lee, Kang-Bong

doi:10.1016/j.forsciint.2011.02.027

Cited by 36 publications

(29 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concentration of CBD in plasma was measured using LC-MS/MS as described previously [25-28] with some modifications. The MS system (QTRAP5500, ABSicex, Framingham, MA, USA) was used in the electrospray ionization mode.…”

Section: Methodsmentioning

confidence: 99%

Development of a Novel Nanoemulsion Formulation to Improve Intestinal Absorption of Cannabidiol

Nakano

Tajima

Sugiyama

et al. 2019

Med Cannabis Cannabinoids

View full text Add to dashboard Cite

Background: Cannabidiol (CBD) is highly lipophilic, and its oral bioavailability is known to be very low in humans. In this study, we developed a novel nanoemulsion preparation of CBD (CBD-NE) to improve the poor solubility and absorption of CBD. The pharmacokinetic profiles of CBD in rats were evaluated after oral administrations of CBD oil and CBD-NE, and the effect of bile secretion on CBD absorption was also evaluated. Methods: The CBD-NE formulation developed in this study consisted of vitamin E acetate, ethanol, Tween-20, and distilled water (1.7/3.8/70/24.5, w/w%). A CBD oil formulation (CBD oil, control) 100 mg/kg or CBD-NE 50 mg/kg was orally administered to rats, and the blood samples were collected over time. Moreover, the CBD oil or CBD-NE was orally administered to bile-fistulated rats, and the pharmacokinetic profiles of CBD were also evaluated. CBD concentrations in plasma were measured using LC-MS/MS. Results: The particle size of CBD-NE was 35.3 ± 11.8 nm. Mean T_max of CBD-NE was shortened significantly by the factor of 3 (from 8.00 to 2.40 h, p < 0.001) and AUC_0–_∞/dose increased by 65% (from 0.272 ± 0.045 to 0.448 ± 0.087 h L/kg) compared with CBD oil. AUC_0–_∞/dose and C_max/dose after oral administration of CBD oil were significantly reduced by the factor of 27 and 23 (p < 0.05 and p < 0.01), respectively, in bile-fistulated rats compared with the untreated rats. In contrast, all pharmacokinetic parameters after oral administration of CBD-NE were not significantly different between the untreated and bile-fistulated rats. Therefore, these results demonstrated that conventional CBD oil formulation but not CBD-NE requires bile-mediated micelle formation. Conclusions: The novel NE formulation developed in this study successfully improved the absorption of CBD regardless of bile secretion. The newly developed oral CBD-NE preparation could be useful to achieve a more stable and quicker onset of action by CBD.

show abstract

Section: Methodsmentioning

confidence: 99%

Development of a Novel Nanoemulsion Formulation to Improve Intestinal Absorption of Cannabidiol

Nakano

Tajima

Sugiyama

et al. 2019

Med Cannabis Cannabinoids

View full text Add to dashboard Cite

show abstract

“…Although a number of different LC, GC/MS or LC-MS/MS methods for analysis of these corticosteroids in pharmaceutical formulations or biological matrices have been published, these steroids added illegally in cosmetic samples have barely been analyzed [11], and we have presented LC-MS/MS method for the quantitative determinations of five corticosteroids in four different cosmetic products (cream, skin, emulsion and essence lotions) sold locally and online in Korea.…”

Section: Analysis Of Cosmetic Productsmentioning

confidence: 99%

“…However, to date, detection of these corticosteroids in cosmetic products has not been reported [1,4,9,11,[18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…Earlier papers have reported various analytical methods such as radioimmunoassay [8], HPLC-UV [9][10][11] and GC-MS [12], LC/MS and LC-MS/MS for monitoring of these corticosteroids in pharmaceutical formulations, biological and urine matrices [13][14][15][16][17]. However, to date, detection of these corticosteroids in cosmetic products has not been reported [1,4,9,11,[18][19][20].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative monitoring of corticosteroids in cosmetic products manufactured in Korea using LC–MS/MS

Nam

Kwon

Lee

et al. 2012

Forensic Science International

Self Cite

View full text Add to dashboard Cite

“…For cosmetic products, illicit substances are also added to enhance short-term cosmetic effectiveness. Common banned additives include antibiotics [10, 11], corticosteroids [12–15], sexual hormones (oestrogens [16], progestogens [16], androgen [17]), pharmacologically active substances [16–18], prohibited preservatives (parabens [19–22], methyldibromoglutaronitrile [23]), whitening agents [13, 24], phthalates [25–28], and nitromusk fragrances [25, 28]. Long-term exposure to these substances could cause adverse effects such as skin irritation, allergic reactions, and antibiotic resistance, which represents a severe risk to public health.…”

Section: Introductionmentioning

confidence: 99%

Direct identification of prohibited substances in cosmetics and foodstuffs using ambient ionization on a miniature mass spectrometry system

Bai

et al. 2016

Analytica Chimica Acta

View full text Add to dashboard Cite

Significantly simplified work flows were developed for rapid analysis of various types of cosmetic and foodstuff samples by employing a miniature mass spectrometry system and ambient ionization methods. A desktop Mini 12 ion trap mass spectrometer was coupled with paper spray ionization, extraction spray ionization and slug-flow microextraction for direct analysis of Sudan Reds, parabens, antibiotics, steroids, bisphenol and plasticizer from raw samples with complex matrices. Limits of detection as low as 5 μg/kg were obtained for target analytes. On-line derivatization was also implemented for analysis of steroid in cosmetics. The developed methods provide potential analytical possibility for outside-the-lab screening of cosmetics and foodstuff products for the presence of illegal substances.

show abstract

Monitoring of clobetasol propionate and betamethasone dipropionate as undeclared steroids in cosmetic products manufactured in Korea

Cited by 36 publications

References 15 publications

Development of a Novel Nanoemulsion Formulation to Improve Intestinal Absorption of Cannabidiol

Development of a Novel Nanoemulsion Formulation to Improve Intestinal Absorption of Cannabidiol

Quantitative monitoring of corticosteroids in cosmetic products manufactured in Korea using LC–MS/MS

Direct identification of prohibited substances in cosmetics and foodstuffs using ambient ionization on a miniature mass spectrometry system

Contact Info

Product

Resources

About

Monitoring of clobetasol propionate and betamethasone dipropionate as undeclared steroids in cosmetic products manufactured in Korea

Cited by 36 publications

References 15 publications

Development of a Novel Nano­emulsion Formulation to Improve Intestinal Absorption of Cannabidiol

Development of a Novel Nano­emulsion Formulation to Improve Intestinal Absorption of Cannabidiol

Quantitative monitoring of corticosteroids in cosmetic products manufactured in Korea using LC–MS/MS

Direct identification of prohibited substances in cosmetics and foodstuffs using ambient ionization on a miniature mass spectrometry system

Contact Info

Product

Resources

About

Development of a Novel Nanoemulsion Formulation to Improve Intestinal Absorption of Cannabidiol

Development of a Novel Nanoemulsion Formulation to Improve Intestinal Absorption of Cannabidiol