Low-permeability reservoirs are important to the future growth of oil and gas reserves and production in China. Predicting the effective stress, σe, in reservoirs is vitally important due to its considerable impact on reservoir development through hydraulic fracturing. This paper presents methods for predicting the σe field in ultralow-permeability reservoirs through reservoir–geomechanics coupling, which involve the simulation and coupling of the tectonic stress σ and pore pressure Pp fields based on three-dimensional (3D) geological models. First, 3D geological models were constructed based on basic data for the oilfield where the reservoir of interest is located. Then, finite element and finite difference simulations were performed to construct the σ and Pp fields, respectively, in the reservoir. Different types of initial σe were coupled based on 3D geological models. Subsequently, a dynamic σe field in the reservoir was established based on oilfield production data in conjunction with the transformation, optimization, and coupling of specific grid property parameters obtained from different numerical methods. Finally, the proposed methods were tested on real-world data acquired from well area X in an oilfield in Shaanxi Province, China. The results show that the proposed methods can be used to establish the σ and Pp fields in a reservoir based on 3D geological models combined with different numerical methods, and subsequently predict the σe value in the reservoir.