More adaptable and user-independent techniques are required for multi-sensors based daily locomotion detection (MS-DLD). This research study proposes a couple of locomotion detection methods using body-worn multi-sensors to successfully categorize several locomotion transitions, including falling, walking, jogging, and jumping, along with bodyspecific sensors based on the modified hidden Markov models (HMMs) approach. This research presents both standard and state-of-the-art methods for MS-DLD. Conventionally, to improve MS-DLD process, the proposed methodology consists of a wavelet transformed Quaternion-based filter for the inertial signals, patterns recognition in the form of kinematic-static energies, and state-of-the-art multi-features extraction. These features include entropy, spectral, and cepstral coefficients domains. Then, fuzzy logic-based optimization has been introduced in order to achieve the selective features by converting them into codewords. This paper also introduces another state-of-the-art way to model daily locomotion detection and derives body-specific modified HMMs. The model divides the sensor data into three active body-specific parts including head sensors, mid-body sensors, and lower body sensors. Body-specific modified HMMs have been provided with raw data for the three active body-specific sensors and gave better results with less computational complexities when compared to the conventional methods. The proposed systems have been experimentally assessed and trialed over three diverse publicly available datasets: the UP-Fall dataset consisting of falling and other daily life activities, the IM-WSHA dataset comprising everyday locomotion actions, and the ENABL3S gait and locomotion dataset consisting of multiple gait movements. Experimental outcomes indicate that the proposed conventional technique achieved improved results and outperformed existing systems based on detection accuracies of 90.0% and 87.5% over UP-Fall, 86.0% and 88.3% over IM-WSHA, and 86.7% and 90.0% over ENABL3S datasets for kinematic and static energy patterns, respectively. Further, the results show that the state-of-the-art body-specific modified HMMs method achieved 94.3% and 95.0% over UP-Fall, 92.0% and 93.3% over IM-WSHA, and 90.0% and 95.0% over ENABL3S datasets for kinematic and static patterned signals, respectively. The results of state-of-theart efficient system show a significant increase in detection accuracy when compared to standard systems.