The International Reference Ionosphere (IRI) is an empirical model widely used to describe ionospheric characteristics. In the previous research, high-precision total ionospheric electron content (TEC) data derived from global navigation satellite system (GNSS) data were used to adjust the ionospheric global index IG12 used as a driving parameter in the standard IRI model; thus, the errors between IRI-TEC and GNSS-TEC were minimized, and IRI-TEC was calibrated by modifying IRI with the updated IG12 index (IG-up). This paper investigates various interpolation strategies for IG-up values calculated from GNSS reference stations and the calibrated TEC accuracy achieved using the modified IRI-2016 model with the interpolated IG-up values as driving parameters. Experimental results from 2015 and 2019 show that interpolating IG-up with a 2.5° × 5° spatial grid and a 1-h time resolution drives IRI-2016 to generate ionospheric TEC values consistent with GNSS-TEC. For 2015 and 2019, the mean absolute error (MAE) of the modified IRI-TEC is improved by 78.57% and 77.42%, respectively, and the root mean square error (RMSE) is improved by 78.79% and 77.14%, respectively. The corresponding correlations of the linear regression between GNSS-TEC and the modified IRI-TEC are 0.986 and 0.966, more than 0.2 higher than with the standard IRI-TEC.