Monitoring the evolution of boron doped porous diamond electrode on flexible retinal implant by OCT and in vivo impedance spectroscopy

Hébert, Clément; Cottance, Myline; Dégardin, Julie; Scorsone, Emmanuel; Rousseau, Lionel; Lissorgues, Gaëlle; Bergonzo, P.; Picaud, Serge

doi:10.1016/j.msec.2016.06.032

Cited by 18 publications

(9 citation statements)

References 38 publications

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“…In recent years, diamond has emerged as a promising electrode material for neurophysiological recording and neurotransmitter sensing. Boron-doped polycrystalline diamond (BDD) offers unique properties, including wide aqueous potential window, chemical inertness, capability for surface modification, tunable electrical conductivity, and biocompatibility (Alcaide et al, 2016;Hébert et al, 2016;McDonald et al, 2017;Yang and Narayan, 2019). Despite the many benefits of this material, the mechanical property mismatch between BDD (Young's module of ∼10 3 GPa) (Wild and Wörner, 2004) and soft tissues is a major obstacle that impedes the development of BDD into fully implantable electrochemical devices.…”

Section: Diamondmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

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Section: Diamondmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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“…However, such complete systems introduce an additional mechanical constraint within a moving eye could lead to potential shear stress at the electrode array which could result in an inflammation. Such functional devices had been for instance produced with titaniumplatinum or diamond electrodes for monitoring the evolution of electrode impedance over time (Linderholm et al, 2013;Hébert et al, 2016). Eye fundus examination and OCT imaging confirmed the absence of abnormal situations (edema and hemorrhage, Linderholm et al, 2013) during the in vivo period.…”

Section: Discussionmentioning

confidence: 99%

Novel Graphene Electrode for Retinal Implants: An in vivo Biocompatibility Study

et al. 2021

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Evaluating biocompatibility is a core essential step to introducing a new material as a candidate for brain-machine interfaces. Foreign body reactions often result in glial scars that can impede the performance of the interface. Having a high conductivity and large electrochemical window, graphene is a candidate material for electrical stimulation with retinal prosthesis. In this study, non-functional devices consisting of chemical vapor deposition (CVD) graphene embedded onto polyimide/SU-8 substrates were fabricated for a biocompatibility study. The devices were implanted beneath the retina of blind P23H rats. Implants were monitored by optical coherence tomography (OCT) and eye fundus which indicated a high stability in vivo up to 3 months before histology studies were done. Microglial reconstruction through confocal imaging illustrates that the presence of graphene on polyimide reduced the number of microglial cells in the retina compared to polyimide alone, thereby indicating a high biocompatibility. This study highlights an interesting approach to assess material biocompatibility in a tissue model of central nervous system, the retina, which is easily accessed optically and surgically.

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“…Diamond electrodes have also been used in retinal interfacing, as reduced glia growth has been observed in comparison with other materials allowing longer‐term implantation. Indeed, work by Hébert et al demonstrated the monitoring of the electrical contact between a flexible diamond electrode on a polyimide substrate and the retina for over four months (Hébert et al, 2016). The same group showed after three months in a minipig model that macrophages did not alter diamond electrode nanostructures, indicating promising long‐term results for BDD in vivo (Torres‐Martinez et al, 2019).…”

Section: Fabrication and Application Of Different Diamond Surfaces Fomentioning

confidence: 99%

Diamond in medical devices and sensors: An overview of diamond surfaces

et al. 2020

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The human body is a sophisticated environment for research. There has been progress in developing advanced medical devices and sensors to contribute to recovery and therapy. However, as the field progresses new materials with specific properties are required to maximize recovery and therapy efficiency. Desired properties include materials that can contribute to cell regeneration and proliferation while preventing bacterial biofilm formation. Additionally, the variability in geometries of diseased parts requires improvement in processing to provide case and geometry-specific solutions (Raghavendra et al., 2015). Hence, there is a need for novel biomaterials that better match the native tissue. Their effectiveness and functionality are crucial to the long-term physical activity and health of patients. Carbon-based materials have attracted attention due to their unique characteristics, including mechanical, thermal and optical properties (Martel-Estrada, 2018), and they have been used in the

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Monitoring the evolution of boron doped porous diamond electrode on flexible retinal implant by OCT and in vivo impedance spectroscopy

Cited by 18 publications

References 38 publications

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Novel Graphene Electrode for Retinal Implants: An in vivo Biocompatibility Study

Diamond in medical devices and sensors: An overview of diamond surfaces

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