Monitoring tumor state from thermal images in animal and human models

Tepper, Michal; Gannot, Israel

doi:10.1118/1.4907967

Cited by 16 publications

(13 citation statements)

References 39 publications

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“…21 Thus, the increased blood perfusion significantly affects the temperature of the tissue, causing heating or cooling. 22 The temperature of the surface tissue also can be affected by alterations in the blood vessels, such as vessel density and blood flow in the area. 13 Skin temperature was also correlated with vessel length determinations.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy Versus Glucose for the Treatment of Telangiectasia: A Randomised Controlled Study in a Rabbit Ear Model

Buzzá

Holmo

Stringasci

et al. 2019

European Journal of Vascular and Endovascular Surgery

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WHAT THIS PAPER ADDS This experimental animal study shows that photodynamic therapy (PDT) of telangiectasia significantly reduces the treated vein length and area temperature without causing severe histological damage, such as necrosis or ulceration. These preliminary findings should stimulate further tests using this new approach for the treatment of telangiectasia. Objectives: Telangiectasia is a common venous formation that mainly affects women and causes discomfort, including psychological distress. This study compared photodynamic therapy (PDT) with glucose for vessel sclerosis in a rabbit ear model. Methods: Thirty-six ears of 18 rabbits were randomly divided into four groups: Group 1: only injection of Photogem (4 mg/mL); Group 2: only light (635 nm, 100 mW/cm 2 , 8 min, 48 J/cm 2); Group 3: glucose 75% injection; Group 4: PDT procedure with injection of Photogem and illumination immediately after. Injections were made into the central ear artery. After injection or sham procedures, manual compression of the marginal vein was maintained for 8 min in all ears. Follow up was immediately after the procedures, and one and six days later. The percentage of length reduction of spider veins, the target vessels, was analysed in digital photographs with Image J software. Ear thermographs were made with a thermocamera device and average temperatures were collected for analysis. Ear biopsies were obtained after six days. Endothelium average, inflammation, fibrosis, necrosis, skin burn, and vascular thrombosis were assessed using a specific score. Results: The mean vessel length reduction was 26% for Group 4, 2.4% for Group 3, .4% for Group 1, and 0 for Group 2, highlighting that in Group 4, the vessel lengths were significantly reduced compared with the other groups (p < .001). In the thermal analysis, in Group 3, the temperature was unchanged from the initial temperature and the central diameter vessel increased after six days, while, in Group 4, the temperature decreased and the vessels were not clearly detected, suggesting a reduction of the vessels and smaller infusion. Histology showed no difference among groups and one case of necrosis was found in Group 4. Conclusions: PDT was associated with significantly more target vessel sclerosis than glucose injection and controls.

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Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy Versus Glucose for the Treatment of Telangiectasia: A Randomised Controlled Study in a Rabbit Ear Model

Buzzá

Holmo

Stringasci

et al. 2019

European Journal of Vascular and Endovascular Surgery

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“…It may be useful in identifying non-responders 71 and monitoring individual progress. 72 This method could be used to understand the functional basis for the immediate improvement upon initiation of propranolol. 73 Future studies with dynamic IR are warranted as investigators seek validated methods to determine IH status.…”

Section: Discussionmentioning

confidence: 99%

Infantile hemangioma status by dynamic infrared thermography: A preliminary study

et al. 2016

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Background Infantile hemangiomas (IH) are initially warm due to increased proliferation perfusion then involute with apoptosis and reduced perfusion. Objective quantitative evaluation of IH treatment response is essential for improving outcomes. We applied a functional imaging method, dynamic infrared (IR) thermography, to investigate IH status versus control skin and over time. Materials and Methods A preliminary prospective observational study was conducted among twenty-five subjects with superficial or mixed IHs (< 19 months) over 59 clinic visits. Infrared images of IHs and control sites, standardized color images and three-dimensional images were obtained. Tissue responses following application and removal of a cold stress were recorded with video IR thermography. Outcomes included areas under the curve during cooling (AUCcool) and rewarming (AUCrw) and thermal intensity distribution maps. Results AUCcool and AUCrw were significantly higher and cooling rate slower for IHs versus uninvolved tissue indicating greater heat, presumably due to greater perfusion and metabolism for the IH. IR distribution maps showed specific areas of high and low temperature. Significant changes in IH thermal activity were reflected in the difference (AUCcool – AUCrw), with 6.2 at 2.2 months increasing to 37.6 at 12.8 months. IH cooling rate increased with age, indicating slower recovery, and interpreted as reduced proliferation and/or involution. Conclusions Dynamic IR thermography was a well-tolerated, quantitative functional imaging modality appropriate for the clinic, particularly when structural changes, i.e., height, volume, color, were not readily observed. It may assist in monitoring progress, individualizing treatment and evaluating therapies.

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“…Thinking about these two points a new tool arises in the attempt to circumvent them, infrared cutaneous thermography. Thermography is considered to be a rapid, non-invasive and painless procedure (Tepper & Gannot, 2015). For these reasons it would rarely require the restraint of the animal, but is still little known by veterinary medicine.…”

Section: Introductionmentioning

confidence: 99%

Use of Thermography in Reconstructive Surgery Associated With Laser Therapy—Review of Literature

Gambardella¹,

Pazzini²,

Barata³

et al. 2019

JAS

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Based on temperature charts, infrared skin thermography is widely used in human medicine, but little known in veterinary medicine. The application of the technique allows orthopedic clinical follow-up as well as aids in the diagnosis of breast tumors in humans, due to its ability to correlate vasculature alterations and tissue vitality with modification of the temperature pattern. For this reason it is applied in veterinary medicine for the detection of joint injuries in horses and animal production, little covering the medicine of small animals. Against of these phages the present study aims to elucidate and suggest its use for the diagnosis and postoperative follow-up of reconstructive surgeries in animals, as well as to evaluate therapeutic measures that seek to improve cutaneous healing, such as low power laser therapy.

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Monitoring tumor state from thermal images in animal and human models

Cited by 16 publications

References 39 publications

Photodynamic Therapy Versus Glucose for the Treatment of Telangiectasia: A Randomised Controlled Study in a Rabbit Ear Model

Photodynamic Therapy Versus Glucose for the Treatment of Telangiectasia: A Randomised Controlled Study in a Rabbit Ear Model

Infantile hemangioma status by dynamic infrared thermography: A preliminary study

Use of Thermography in Reconstructive Surgery Associated With Laser Therapy—Review of Literature

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