Monitorizando a terapia de reposição estrogênica (TRE) na menopausa

Wygoda, Márcia Magalhães; Filippo, Roberto Brando; Gomes, Maria Amélia S.; Clapauch, Ruth

doi:10.1590/s0004-27301999000500005

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…Weight did not change in the three groups during follow-up. The same variation in waist circumference was demonstrated by our group in postmenopausal women, at the beginning of hormone replacement therapy (35). With regard to waist-to-hip ratio, some studies have shown that testosterone replacement rapidly improved this ratio, particularly when associated with regular physical exercise (36), thus representing an important parameter for metabolic syndrome improvement.…”

Section: Discussionsupporting

confidence: 79%

Short term testosterone replacement therapy improves libido and body composition

Júnior¹,

Clapauch²,

Buksman

2009

Arq Bras Endocrinol Metab

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Objective: To assess the efficacy and safety of testosterone replacement in males with late-onset hypogonadism compared to hypogonadal men without replacement, and controls, during six months. Methods: We assessed, through ADAM, AMS, IIEF-5 and SF-36 questionnaires, and through clinical and laboratorial examinations, 62 patients divided into three groups: 17 hypogonadal males (HR) used intramuscular testosterone every three weeks; 14 hypogonadal males (HV) and 31 non-hypogonadal males (CV) used oral vitamins daily. Results: When compared to others, HR group obtained libido improvement assessed by ADAM 1 (p = 0.004), and borderline sexual potency improvement assessed by IIEF-5 (p = 0.053), besides a decrease in waist circumference after eight weeks (p = 0.018). The remaining parameters did not differ between the groups. PSA and hematocrit remained stable in those using testosterone. Conclusion: Six months of testosterone replacement improved sexuality and body composition, with prostatic and hematological safety. KeywordsTestosterone replacement therapy; late onset hypogonadism; andropause; libido; body composition; waist circumference resumo Objetivo: Avaliar a eficácia e a segurança da reposição de testosterona em homens com hipogonadismo tardio comparados a hipogonádicos sem reposição e controles, durante seis meses. Métodos: Mediante os questionários ADAM, AMS, IIEF-5 e SF-36, foram feitos exame clínico e laboratorial em 62 pacientes divididos em três grupos: 17 hipogonádicos (HR) usaram testosterona intramuscular a cada três semanas; 14 hipogonádicos (HV) e 31 não hipogonádi-cos (CV) usaram vitaminas via oral diariamente. Resultados: Comparado aos demais, o grupo HR obteve melhora da libido avaliada pelo ADAM 1 (p = 0,004) e melhora limítrofe da potência sexual avaliada pelo IIEF-5 (p = 0.053), além de diminuição da cintura a partir da oitava semana (p = 0,018). Os demais parâmetros não foram diferentes entre os grupos. PSA e hematócrito se mantiveram estáveis nos que usaram testosterona. Conclusão: A reposição de testosterona durante seis meses melhorou a sexualidade e a composição corporal, com segurança prostática e hematológica. Arq Bras Endocrinol Metab. 2009;53(8):996-1004 Descritores

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Section: Discussionsupporting

confidence: 79%

Short term testosterone replacement therapy improves libido and body composition

Júnior¹,

Clapauch²,

Buksman

2009

Arq Bras Endocrinol Metab

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“…Growth hormone therapy is associated with some collateral effects, including edema and is also correlated to insulin resistance, which can deteriorate endothelial function. 30 The same effect is reported with use of estrogens 31 and the high prevalence found in this study may be explained by this collateral effect. On the other hand, estrogen receptors are present in vascular smooth muscle and endothelial cells and the use of estrogen therapy has a favorable effect on cardiovascular hemodynamics in TS.…”

Section: Discussionsupporting

confidence: 69%

Nailfold video capillaroscopy in Turner syndrome: a descriptive study

et al. 2007

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BACKGROUND: An increased prevalence of impaired glucose homeostasis is reported in Turner syndrome. Endothelial changes are described in patients with insulin resistance, which may be present in patients with Turner syndrome. Video capillaroscopy is a noninvasive examination that allows assessment of vascular patency. OBJECTIVE: To describe the nailfold morphology of capillaries in Turner syndrome using video capillaroscopy. METHODS: Subjects were studied in a temperature-controlled room, 20 days after no nailfold manipulations. The capillaries were visualized by microscope connected to a television and computer and were studied and classified according to these patterns: loop distribution, papilla, avascular fields, edema, form, capillary limbs, flow and hemorrhagic extravasation. RESULTS: Fifty patients aged between 6-37 years with Turner syndrome were studied. Eighteen (36%) patients had normal capillaroscopy with hairpin pattern in loop distribution and no avascular fields. The papilla was ratified in 13 (26%) and enlarged in four (8%). Edema occurred in 22 (44%) cases. There were three (6%) macrocapillaries and three (6%) were branched. Tortuosity was present in five (10%) patients. Hemorrhagic extravasation occurred in one (2%) case. Flow was fast in seven (14%), granulous in five (10%) and slow in six (12%). CONCLUSION: There was a high prevalence of nailfold capillaroscopy changes in Turner syndrome and the most prevalent alterations found were edema and ratified papilla.

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“…During the interval between NVC, the participant was asked about color, TSM, timing and duration of HT, previous oral contraceptive (OC) use, past smoking, and current vasomotor symptoms, quantified subjectively from 0 (no symptoms) to 10 (very intense symptoms). 19 BP was determined from two measurements at least 2 minutes apart. Height, weight, waist circumference (halfway between the costal margin and the iliac crest on the midclavicle line), and body mass index (BMI, in kilograms per square meter) were assessed.…”

Section: Methodsmentioning

confidence: 99%