Monkey brain cortex imaging by photoacoustic tomography

Yang, Xinmai; Wang, Lihong V.

doi:10.1117/1.2967907

Cited by 87 publications

(79 citation statements)

References 26 publications

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“…[15][16][17][18][19] Because the skulls in those studies were relatively thin (∼1 mm), they did not significantly aberrate the PA signals and conventional backprojection methods were employed for image reconstruction. However, PA signals can be significantly aberrated by thicker skulls present in adolescent and adult primates.…”

Section: Introductionmentioning

confidence: 99%

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Huang

2012

J. Biomed. Opt

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Abstract. A challenge in photoacoustic tomography (PAT) brain imaging is to compensate for aberrations in the measured photoacoustic data due to their propagation through the skull. By use of information regarding the skull morphology and composition obtained from adjunct x-ray computed tomography image data, we developed a subject-specific imaging model that accounts for such aberrations. A time-reversal-based reconstruction algorithm was employed with this model for image reconstruction. The image reconstruction methodology was evaluated in experimental studies involving phantoms and monkey heads. The results establish that our reconstruction methodology can effectively compensate for skull-induced acoustic aberrations and improve image fidelity in transcranial PAT.

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Section: Introductionmentioning

confidence: 99%

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Huang

2012

J. Biomed. Opt

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“…The vascular structures of a monkey brain with an approximately 2-mm-thick skull through the intact scalp and skull bone were identified by PAT. Without the intact skull, the main structures of the exposed brain cortex were observable by PAT with greater clarity than with skull in place [45].…”

Section: Photoacoustic Imaging Of the Brainmentioning

confidence: 98%

“…The application of PAT in brain imaging has been extended to large animals with thicker skull bones as well [45,46]. The vascular structures of a monkey brain with an approximately 2-mm-thick skull through the intact scalp and skull bone were identified by PAT.…”

Section: Photoacoustic Imaging Of the Brainmentioning

confidence: 99%

Potential for photoacoustic imaging of the neonatal brain

Tavakolian¹,

Kosik

Chamson-Reig³

et al. 2013

SPIE Proceedings

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Photoacoustic imaging is a hybrid imaging technique that combines many of the merits of both optical and ultrasound imaging. Photoacoustic imaging (PAI) has been hypothesized as a technique for imaging neonatal brain. However, PAI of the brain is more challenging than traditional methods (e.g. near infrared spectroscopy) due to the presence of the skull layer.To evaluate the potential limits the skull places on 3D PAI of the neonatal brain, we constructed a neonatal skull phantom (~1.52-mm thick) with a mixture of epoxy and titanium dioxide powder that provided acoustic insertion loss (1-5MHz) similar to human infant skull bone. The phantom was molded into a realistic infant skull shape by means of a CNCmachined mold that was based upon a 3D CAD model. Then, propagation of photoacoustic (PA) signals through the skull phantom was examined. A photoacoustic point source was raster-scanned within the imaging cavity of a 128-channel PAI system to capture the imaging operator with and without the intervening skull phantom layer. Then, effects of the skull phantom on PA signals and consequently on PA images was evaluated in detail. We captured 3D photoacoustic images of tubes filled with indocyanine green (ICG). The system was capable of reconstructing an image of a tube filled with 50 µM ICG in presence of the skull.Image processing method was developed to correct photoacoustic images from the effects of the skull. The method was tested on an image of an object captured through the skull, which demonstrated that the effects of the skull on PA images are predictable and modifiable.

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“…[6][7][8][9][10][11][12][13][14][15][16][17][18][19] In PAT, an expanded pulsed laser beam illuminates the imaging area homogeneously. [20][21][22][23][24][25][26][27][28] The laser-induced photoacoustic signal can be acquired using either singleelement scanning or multi-element array detection, which determines the imaging speed and image quality with various time-reversal reconstruction algorithms.…”

Section: Introductionmentioning

confidence: 99%

Low-cost photoacoustic imaging systems based on laser diode and light-emitting diode excitation

Yao

Ding

Liu

et al. 2017

J. Innov. Opt. Health Sci.

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Photoacoustic imaging, an emerging biomedical imaging modality, holds great promise for preclinical and clinical researches. It combines the high optical contrast and high ultrasound resolution by converting laser excitation into ultrasonic emission. In order to generate photoacoustic signal e±-ciently, bulky Q-switched solid-state laser systems are most commonly used as excitation sources and hence limit its commercialization. As an alternative, the miniaturized semiconductor laser system has the advantages of being inexpensive, compact, and robust, which makes a signi¯cant e®ect on production-forming design. It is also desirable to obtain a wavelength in a wide range from visible to nearinfrared spectrum for multispectral applications. Focussing on practical aspect, this paper reviews the state-of-the-art developments of low-cost photoacoustic system with laser diode and light-emitting diode excitation source and highlights a few representative installations in the past decade.

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Monkey brain cortex imaging by photoacoustic tomography

Cited by 87 publications

References 26 publications

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Potential for photoacoustic imaging of the neonatal brain

Low-cost photoacoustic imaging systems based on laser diode and light-emitting diode excitation

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