Monkey Pox Disease in Irradiated Cynomologous Monkeys

McConnell, Stewart; Herman, Yaye F.; Mattson, D. E.; Erickson, L.M.

doi:10.1038/1951128a0

Cited by 46 publications

(36 citation statements)

References 2 publications

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“…A second outbreak of MPXV was reported in the USA in two M. fascicularis monkeys approximately 45 days after exposure to whole-body irradiation [36]. Lesions were clinically similar to those described by Von Magnus et al and Prier et al [34,37], that is: pox-like eruptions, severe facial and cervical edema, hemorrhagic ulcerations, dyspnea and bloody diarrhea.…”

Section: Discovery Of Mpxv and Natural Outbreakssupporting

confidence: 58%

“…One nonirradiated monkey also became sick with cervical edema and ulcerated areas on the arms and forehead; however, this animal survived. HAI titers from animals housed in the same room as those exhibiting disease revealed that 89% of animals were positive; in contrast, only 11% of animals held in separate rooms were positive [36]. …”

Section: Discovery Of Mpxv and Natural Outbreaksmentioning

confidence: 99%

“…challenge with 10 5.5 median tissue culture infective dose (TCID 50 ) of MPXV isolated from the second US outbreak [36]. Challenge at 35 days postvaccination resulted in no disease manifestations in five out of six monkeys; however, one animal developed bloody diarrhea and died 9 days p.i.…”

Section: Early Experimental Studies On Mpxv Pathogenesis In M Fascicmentioning

confidence: 99%

“…Interestingly, SCR and id. serial passages were successful in many animals [36,38,41,79] and generated red, indurated lesions with black-brown necrotic centers [79]. sc.…”

Section: Experimental and Natural Mpx In Small Animalsmentioning

confidence: 99%

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A Review of Experimental and Natural Infections of Animals with Monkeypox Virus Between 1958 and 2012

2013

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Monkeypox virus (MPXV) was discovered in 1958 during an outbreak in an animal facility in Copenhagen, Denmark. Since its discovery, MPXV has revealed a propensity to infect and induce disease in a large number of animals within the mammalia class from pan-geographical locations. This finding has impeded the elucidation of the natural host, although the strongest candidates are African squirrels and/or other rodents. Experimentally, MPXV can infect animals via a variety of multiple different inoculation routes; however, the natural route of transmission is unknown and is likely to be somewhat species specific. In this review we have attempted to compile and discuss all published articles that describe experimental or natural infections with MPXV, dating from the initial discovery of the virus through to the year 2012. We further discuss the comparative disease courses and pathologies of the host species.

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Section: Discovery Of Mpxv and Natural Outbreakssupporting

confidence: 58%

Section: Discovery Of Mpxv and Natural Outbreaksmentioning

confidence: 99%

Section: Early Experimental Studies On Mpxv Pathogenesis In M Fascicmentioning

confidence: 99%

“…Interestingly, SCR and id. serial passages were successful in many animals [36,38,41,79] and generated red, indurated lesions with black-brown necrotic centers [79]. sc.…”

Section: Experimental and Natural Mpx In Small Animalsmentioning

confidence: 99%

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A Review of Experimental and Natural Infections of Animals with Monkeypox Virus Between 1958 and 2012

2013

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“…As indicated above, natural poxvirus infections of nonhuman primates do occur and have been reported in a variety of monkeys and apes: rhesus, cynomolgus, other macaques, chimpanzee, gorilla, and orangutan (104,118,235,270,271,347). Espafia (personal communication) described an outbreak of monkey pox in various species of monkeys, including a number heretofore not incriminated (Presbytis cristatus and M. nemestrina).…”

Section: Poxvirusesmentioning

confidence: 94%