Monkeypox Attack

Mullendore, Nicole F.; Lawner, Benjamin J.; Malone, John D.

doi:10.1016/b978-0-323-28665-7.00149-7

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Although DNA from the monkeypox virus has been discovered in seminal fluids, it is presently uncertain whether sperm and vaginal secretions can transfer the infection. Close or intimate physical contact can aid in the spread of pathogens through respiratory and contact routes [ 1 , 39 , 40 , 41 ].…”

Section: Pathogenesismentioning

confidence: 99%

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Monkeypox: An Emerging Global Public Health Emergency

Jeyaraman

Selvaraj

Halesh

et al. 2022

Life

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The virus causing monkeypox, a rare zoonotic viral disease, belongs to the Poxviridae family and the Orthopoxvirus genus. On 23 July 2022, the World Health Organization (WHO) declared the monkeypox outbreak as a Public Health Emergency of International Concern (PHEIC). From May to July 2022, a multi-country outbreak of monkeypox was reported in both endemic and non-endemic regions. Major goals of managing monkeypox are to identify the suspected cases, detect generic orthopoxvirus DNA at a state or commercial laboratory, and establish the Centers for Disease Control and Prevention real-time polymerase chain reaction testing. Currently, there are no approved treatments for monkeypox virus infection. However, a variety of antiviral medications originally designed for the treatment of smallpox and other viral infections could be considered. Pre-exposure prophylaxis for laboratory and health care employees and post-exposure prophylaxis for individuals with high-risk or intermediate-risk exposures are to be considered. The CDC Emergency Operations Center is available for advice on the appropriate use of medical countermeasures, and can help in obtaining antiviral drugs and vaccines from the National Strategic Stockpile. This review gives an overview of the global scenario, clinical presentation, and management of monkeypox in the light of a global public health emergency.

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Section: Pathogenesismentioning

confidence: 99%

“…Sexual activity, especially male-to-male sexual contact was reported [ 15 , 17 , 41 , 42 ]. Most cases in the ongoing 2022 outbreak worldwide, including those in the United States, have been in men who identify as gay or bisexual or in other men who have sex with men.…”

Section: Pathogenesismentioning

confidence: 99%

Monkeypox: An Emerging Global Public Health Emergency

Jeyaraman

Selvaraj

Halesh

et al. 2022

Life

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“…It is believed to reach maximal protection four weeks following administration and, as a direct derivative of the Dryvax vaccine used against smallpox, has effectiveness in preventing orthopoxviruses including MPX. 35,40 Both vaccines are authorized for patients above the age of 18 with one of the following risk criteria: close contact or sexual activity with someone diagnosed with MPX; sexual activity in an area with known MPX; or work in a high-risk setting such as laboratory, healthcare, and public health. JYNNEOS is recommended for immunocompromised patients as ACAM2000 has the potential for uncontrolled systemic replication, which could https://doi.org/10.2147/RRU.S381191 DovePress lead to serious adverse effects in this population.…”

Section: Impact Of Outbreak For Urologistsmentioning

confidence: 99%

Male Sexual Health Implications of the 2022 Global Monkeypox Outbreak

White¹,

Rivero²,

Mohamed³

et al. 2022

RRU

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The 2022 global monkeypox (MPX) outbreak is the largest in history to occur outside of endemic African regions. Disease spread during this outbreak has been primarily through human-to-human transmission, with sexual contact being of particular concern. Clinical presentations have commonly featured genital, perianal, and oral lesions associated with sexual activity among men who have sex with men (MSM), who compose the vast majority of MPX cases. This review discusses the epidemiology, clinical features, and evaluation of MPX with regards to men's sexual health. Comparisons were made between MPX and its relative from the Orthopoxvirus genus, smallpox, in order to make informed inferences on the potential effects of MPX on men's sexual health. This review also discusses the role of men's health specialists and urologists in addressing the current outbreak.

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Candidate Vaccines and Therapeutics against Monkeypox Infection

Nainwal¹,

Jakhmola²

2022

J. Pure Appl. Microbiol.

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While human beings are still facing the challenges of the pandemic coronavirus disease (COVID-19), a new viral disease, monkeypox raises concerns among healthcare authorities about this new threat. Since May 2022, thousands of people have been affected by a continuous monkeypox outbreak linked to close contact transmission in numbers of nonendemic nations. The Food and Drug Administration (FDA) has not yet approved any medications to treat monkeypox in humans. However, medications created for smallpox patients, such as antivirals and other medical countermeasures, might also be effective against monkeypox. Tecovirimat (TPOXX), brincidofovir, cidofovir antivirals and Vaccinia Immune Globulin Intravenous (VIGIV) are the medical countermeasures for the treatment of monkeypox. The second and third generations of smallpox vaccinations have been developed after many years of research. Some of these vaccines may also be beneficial for monkeypox. Three vaccinations, MVA-BN, LC16, or ACAM2000 can be used for monkeypox. Two of these (MVA-BN and LC16) have received approval for the purpose of preventing monkeypox. Considering the current vaccine shortage, widespread immunisation is not advised. Therefore, prevention is the best policy to keep everyone safe. The current review highlights the treatment available for the management of monkeypox. It also reviewed the preventive measures that human beings should take to protect themselves from monkeypox infection.

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Monkeypox Attack

Cited by 3 publications

References 4 publications

Monkeypox: An Emerging Global Public Health Emergency

Monkeypox: An Emerging Global Public Health Emergency

Male Sexual Health Implications of the 2022 Global Monkeypox Outbreak

Candidate Vaccines and Therapeutics against Monkeypox Infection

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