Mono-(2-ethylhexyl) phthalate induces oxidative stress and lipid accumulation in zebrafish liver cells

Park, Chang Gyun; Sung, Baeckkyoung; Ryu, Chang Seon; Kim, Young Jun

doi:10.1016/j.cbpc.2020.108704

Cited by 36 publications

(12 citation statements)

References 35 publications

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“…In this regard, a decrease in superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) enzymatic activity with glutathione/glutathione disulfide (GSH/GSSH) ratio appears to be a significant importance event. Oxidative stress has been reported to occur after exposure to BPA [ 124 ], PFOS [ 125 ], PCB156 [ 126 ], MEPH [ 127 ], and Cd [ 111 ], among others, both in vivo and in vitro. Besides, an increase in mitochondrial ROS following EDC exposure also promotes an increase in 4-Hydroxy-nonenal (4-HNE) and malondialdehyde (MDA) (LPO products and oxidative stress markers), which, in turn, lead to cell membrane disturbance and exacerbation of liver damage [ 126 ].…”

Section: Mechanisms Of Action Of Endocrine-disrupting Chemicals In Nafldmentioning

confidence: 99%

Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

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Angarita

et al. 2021

IJMS

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Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required.

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Section: Mechanisms Of Action Of Endocrine-disrupting Chemicals In Nafldmentioning

confidence: 99%

Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Cano

Pérez

Angarita

et al. 2021

IJMS

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“…They can be found in soils [ 6 , 29 ], food products [ 30 , 31 , 32 ], human breast milk [ 7 , 33 ], indoor air [ 34 ], bottled water [ 35 , 36 ], cosmetics [ 37 ], etc. Because of their lipophilic properties, phthalates can accumulate in lipids and cause serious damage, e.g., to human liver [ 38 , 39 ]. Studies describing the impact of phthalates on human health have shown that they seriously influence the production of hormones and cause endocrine disturbances, which can entail considerable risks of autism, endometriosis, asthma, and difficulties in pregnancy [ 28 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Attempts in the Design of Efficient PVC Plasticizers with Reduced Migration

2021

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This paper reviews the current trends in replacing commonly used plasticizers in poly(vinyl chloride), PVC, formulations by new compounds with reduced migration, leading to the enhancement in mechanical properties and better plasticizing efficiency. Novel plasticizers have been divided into three groups depending on the replacement strategy, i.e., total replacement, partial replacement, and internal plasticizers. Chemical and physical properties of PVC formulations containing a wide range of plasticizers have been compared, allowing observance of the improvements in polymer performance in comparison to PVC plasticized with conventionally applied bis(2-ethylhexyl) phthalate, di-n-octyl phthalate, bis(2-ethylhexyl) terephthalate and di-n-octyl terephthalate. Among a variety of newly developed plasticizers, we have indicated those presenting excellent migration resistance and advantageous mechanical properties, as well as those derived from natural sources. A separate chapter has been dedicated to the description of a synergistic effect of a mixture of two plasticizers, primary and secondary, that benefits in migration suppression when secondary plasticizer is added to PVC blend.

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“…These genes are known for their activities in the metabolism of xenobiotics and function in the generation of ROS [ 34 , 35 , 36 , 37 , 38 ]. Recent studies have shown that especially CYP1A1 acts as a primary regulator in AhR-mediated lipid production, thereby causing lipid accumulation, and CYP1A1 expression, stimulated by ROS, also contributes to the accumulation of lipid droplets in hepatocytes [ 39 , 40 ]. Taken together, B[a]P binding to AhR induces lipid accumulation, which can cause NAFLD, through the CYP1A1-mediated pathway and induces ROS generation by upregulating CYP1A1 and CYP1B1 [ 35 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Suppresses the Lipid Accumulation and Oxidative Stress Induced by Benzo[a]pyrene Toxicity in HepG2 Cells

et al. 2021

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Benzo[a]pyrene (B[a]P) is a potentially hepatotoxic group-1 carcinogen taken up by the body through ingestion of daily foods. B[a]P is widely known to cause DNA and protein damages, which are closely related to cell transformation. Accordingly, studies on natural bioactive compounds that attenuate such chemical-induced toxicities have significant impacts on public health. This study aimed to uncover the mechanism of curcumin, the major curcuminoid in turmeric (Curcuma longa), in modulating the lipid accumulation and oxidative stress mediated by B[a]P cytotoxicity in HepG2 cells. Curcumin treatment reduced the B[a]P-induced lipid accumulation and reactive oxygen spicies (ROS) upregulation and recovered the cell viability. Cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and Cytochrome P450 subfamily B polypeptide 1 (CYP1B1) downregulation resulting from decreased aryl hydrocarbon receptor (AhR) translocation into nuclei attenuated the effects of B[a]P-induced lipid accumulation and repressed cell viability, respectively. Moreover, the curcumin-induced reduction in ROS generation decreased the nuclear translocation of Nuclear factor erythroid-2-related factor 2 (Nrf2) and the expression of phase-II detoxifying enzymes. These results indicate that curcumin suppresses B[a]P-induced lipid accumulation and ROS generation which can potentially induce nonalcoholic fatty liver disease (NAFLD) and can shed a light on the detoxifying effect of curcumin.

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Mono-(2-ethylhexyl) phthalate induces oxidative stress and lipid accumulation in zebrafish liver cells

Cited by 36 publications

References 35 publications

Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Recent Attempts in the Design of Efficient PVC Plasticizers with Reduced Migration

Curcumin Suppresses the Lipid Accumulation and Oxidative Stress Induced by Benzo[a]pyrene Toxicity in HepG2 Cells

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