Mono and dinuclear ruthenium, rhodium and iridium metal complexes containing N-acylhydrazone moiety: Synthesis and in vitro biological studies

Nongpiur, Carley Giffert L.; Diengdoh, Danny F; Nagar, Nupur; Poluri, Krishna Mohan; Gannon, Paige M.; Kaminsky, Werner; Kollipara, Mohan Rao

doi:10.1016/j.poly.2022.115855

Cited by 2 publications

(1 citation statement)

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“…The study of hydrazone molecules and their metal complexes has garnered significant interest within the fields of organic and coordination chemistry due to their remarkable coordination abilities, diverse physiological activities, luminescence properties, and wide range of applications in various areas such as pharmacological, biological, catalytic, and analytical fields of chemistry . Hydrazones are a significant group of organic compounds having a broad spectrum of pharmacological activities predominantly and anti-inflammatory, analgesic, antimicrobial, antifungal, anticancer, and antidepressant activities . Hydrazone applications in organic chemistry was first established by Emil Fischer in 1884 and proved to be a Schiff base-type compound .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic and Nonlinear Optical Properties, and Antimicrobial Activity of Cu(II), Co(II), and Ni(II) Complexes: Experimental and Theoretical Studies

Hussain,

Rubab,

Maryam

et al. 2023

ACS Omega

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Currently, we report the preparation of transition metal complexes Co(II), Ni(II), and Cu(II) of hydrazone Schiff base ligands, which are obtained by the condensation reaction of substituted salicylaldehyde and hydrazines. The synthesized hydrazone ligands and their metal complexes were characterized by spectroscopic methods such as Fourier transform infrared (FT-IR), UV–vis, nuclear magnetic resonance (1H NMR and C13 NMR), and mass spectrometry analyses. All of the quantum chemistry calculations were performed using DFT executed in the Gaussian 09 software package. The geometry was optimized by using the density functional theory (DFT) approximation at the B3LYP level with a basis set of 6-31G (d, p). There was excellent agreement between the FT-IR values obtained experimentally and those obtained theoretically for the test compounds. It is worth noting that none of the optimized geometries for any of the Schiff base and metal complexes had any eigenvalues that were negative, indicating that these geometries represent the true minimum feasible energy surfaces. We also analyzed the electrostatic potential of the molecule and NBO calculation at the same level of theory. Gauss View 6 was utilized for the file organization of the input data. Gauss View 6.0, Avogadro, and Chemcraft were used to determine the data. Additionally, synthesized compounds were screened for antimicrobial activity against Gram-negative bacteria (Salmonella typhi, Escherichia coli) and Gram-positive bacteria (Bacillus halodurans, Micrococcus luteus) and two fungal strains (Aspergillus flavus, Aspergillus niger). These research findings have established the potential of ligands and their metal complexes as antimicrobial agents. Additionally, the compounds demonstrated promising nonlinear optical (NLO) properties, with potential applications across a wide range of contemporary technologies.

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