Mono-macrophage-Derived MANF Protects Against Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting Inflammation and Renal M1 Macrophages

Hou, Chao; Mei, Qiong; Song, Xuegang; Qin, Bangyong; Li, Xiang; Wang, Dong; Shen, Yujun

doi:10.1007/s10753-020-01368-w

Cited by 24 publications

(20 citation statements)

References 41 publications

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“…MANF also promotes immune cell phenotype switch from proinflammatory macrophages to pro-repair anti-inflammatory macrophages [ 49 ]. MANF is therefore considered as a negative regulator of inflammation [ 52 ]. Further, restoring MANF levels can extend fly lifespan, reverse liver damage and inflammation in old mice by regulating metabolic and immune homeostasis in ageing [ 49 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases

Seny

Baiwir

Bianchi

et al. 2021

IJMS

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An inflamed synovial membrane plays a major role in joint destruction and is characterized by immune cells infiltration and fibroblast proliferation. This proteomic study considers the inflammatory process at the molecular level by analyzing synovial biopsies presenting a histological inflammatory continuum throughout different arthritis joint diseases. Knee synovial biopsies were obtained from osteoarthritis (OA; n = 9), chronic pyrophosphate arthropathy (CPPA; n = 7) or rheumatoid arthritis (RA; n = 8) patients. The histological inflammatory score was determined using a semi-quantitative scale based on synovial hyperplasia, lymphocytes, plasmocytes, neutrophils and macrophages infiltration. Proteomic analysis was performed by liquid chromatography-mass spectrometry (LC-MS/MS). Differentially expressed proteins were confirmed by immunohistochemistry. Out of the 1871 proteins identified and quantified by LC-MS/MS, 10 proteins (LAP3, MANF, LCP1, CTSZ, PTPRC, DNAJB11, EML4, SCARA5, EIF3K, C1orf123) were differentially expressed in the synovial membrane of at least one of the three disease groups (RA, OA and CPPA). Significant increased expression of the seven first proteins was detected in RA and correlated to the histological inflammatory score. Proteomics is therefore a powerful tool that provides a molecular pattern to the classical histology usually applied for synovitis characterization. Except for LCP1, CTSZ and PTPRC, all proteins have never been described in human synovitis.

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Section: Discussionmentioning

confidence: 99%

New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases

Seny

Baiwir

Bianchi

et al. 2021

IJMS

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“…Specifically, in response to retinal damage signals, the expression of MANF is transiently induced in innate immune cells and immune cell-derived MANF promotes a phenotype switch of macrophages from proinflammatory to anti-inflammatory in an autocrine manner [47] (Figure 2). Moreover, studies also showed that MANF knockout in mouse monomacrophages increased splenic [48], renal [49], and myocardial [50] M1-macrophages, whereas another study found that MANF transiently increased the number of phagocytic innate immune cells to promote functional recovery in post-stroke rats but did not recruit alternatively activated macrophages [51].…”

Section: Open Accessmentioning

confidence: 99%

MANF: an emerging therapeutic target for metabolic diseases

Tang

2022

Trends in Endocrinology & Metabolism

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Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum-resident protein and a secretory factor and has beneficial effects in multiple diseases. Recent evidence shows that its circulating levels in humans are dynamically regulated under various metabolic diseases, including diabetes, obesity, fatty liver, and cardiovascular diseases, suggesting that MANF may play a role in these pathological states. Also, its downregulation in mice impairs glucose homeostasis, promotes lipid accumulation in the liver, reduces energy expenditure, and induces inflammation. Conversely, MANF overexpression prevents or mitigates some of these metabolic disturbances. In particular, systemic MANF administration alleviates dietary obesity and related metabolic disorders in obese mice. We therefore propose that MANF might be a promising target for treating chronic metabolic diseases. HighlightsMesencephalic astrocyte-derived neurotrophic factor (MANF) is highly expressed in metabolically active tissues such as pancreas, liver, and hypothalamus. MANF circulating level is dynamically regulated under various metabolic diseases such as type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and obesity.MANF downregulation in mice induces various metabolic disturbances. Conversely, increasing MANF expression prevents or mitigates these disorders.Systemic MANF protein administration retards body weight gain and improves glucose homeostasis in obese mice.MANF can function intracellularly (via endoplasmic reticulum stress-dependent and -independent mechanisms) and extracellularly (via receptors or endocytosis).

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“…All the above can be regarded as characteristics of M1 macrophages. Meanwhile, M1 macrophages showed stronger phagocytosis and antigen-presenting ability, which could eliminate the necrotic cells ( Hou et al, 2020 ). However, excessive secretion of pro-inflammatory cytokines, reactive oxygen species (ROS), and reactive nitrogen species (RNS) after M1 cell polarization can impair neurons and glia and even cause more serious neuron apoptosis ( Block et al, 2007 ).…”

Section: Hematogenous Macrophages Participate In Spinal Cord Injury Pathologymentioning

confidence: 99%

Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury

Ding

Zhang

Wang

et al. 2021

Front. Cell Dev. Biol.

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Spinal cord injury (SCI) is a devastating disease leading to loss of sensory and motor functions, whose pathological process includes mechanical primary injury and secondary injury. Macrophages play an important role in SCI pathology. According to its origin, it can be divided into resident microglia and peripheral monocyte-derived macrophages (hematogenous Mφ). And it can also be divided into M1-type macrophages and M2-type macrophages on the basis of its functional characteristics. Hematogenous macrophages may contribute to the SCI process through infiltrating, scar forming, phagocytizing debris, and inducing inflammatory response. Although some of the activities of hematogenous macrophages are shown to be beneficial, the role of hematogenous macrophages in SCI remains controversial. In this review, following a brief introduction of hematogenous macrophages, we mainly focus on the function and the controversial role of hematogenous macrophages in SCI, and we propose that hematogenous macrophages may be a new therapeutic target for SCI.

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Mono-macrophage-Derived MANF Protects Against Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting Inflammation and Renal M1 Macrophages

Cited by 24 publications

References 41 publications

New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases

New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases

MANF: an emerging therapeutic target for metabolic diseases

Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury

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