Monoamine Oxidase Inhibitors

Ho, Beng T.

doi:10.1002/jps.2600610602

Cited by 71 publications

(13 citation statements)

References 125 publications

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“…The mechanism of MAOIs is the inhibition of monoamine oxidase, an enzyme blocking the metabolic breakdown of norepinephrine and serotonin, but also of dopamine, ensuing in an intrasynaptic elevation of the concentrations of all three biogenic amines [40]. Taken together, these data suggest that a reduction of monoaminergic activity could lead to underlying depression.…”

Section: Dopamine Mania/hypomania and Depressionmentioning

confidence: 99%

Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness

Demontis

Serra

2017

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Background: Mania seems to be associated with an increased dopamine (DA) transmission. Antidepressant treatments can induce mania in humans and potentiated DA transmission in animals, by sensitizing DA D2 receptors in the mesolimbic system. We have suggested that the sensitization of D2 receptors may be responsible of antidepressant-induced mania. This review aims to report the experimental evidence that led to the hypothesis that antidepressant-induced DA receptors dysregulation can be considered an animal model of bipolar disorder.Methods: We reviewed papers reporting preclinical and clinical studies on the role of DA in the mechanism of action of antidepressant treatments and in the patho-physiology of mood disorders.Results: A number of preclinical and clinical evidence suggests that mania could be associated with an increased DA activity, while a reduced function of this neurotransmission might underlie depression. Chronic treatment with imipramine induces a sensitization of DA D2 receptors in the mesolimbic system, followed, after drug discontinuation, by a reduced sensitivity associated with an increased immobility time in forced swimming test of depression (FST). Blockade of glutamate NMDA receptors by memantine administration prevents the imipramine effect on DA receptors sensitivity and on the FST.Conclusion: We suggest that chronic treatment with antidepressants induces a behavioural syndrome that mimics mania (the sensitization of DA receptors), followed by depression (desensitization of DA receptors and increased immobility time in the FST), i.e. an animal model of bipolar disorder. Moreover the observation that memantine prevents the “bipolar-like” behavior, suggests that the drug may have an antimanic and mood stabilizing effect. Preliminary clinical observations support this hypothesis.

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Section: Dopamine Mania/hypomania and Depressionmentioning

confidence: 99%

Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness

Demontis

Serra

2017

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“…From a long time, the alkaloids containing the 1,2,3,4-tetrahydro-β-carboline (THBC) skeleton have represented important lead structures in view of their wide range of biological activities [1], mainly due to their interaction with the central nervous system [2–7]. Moreover, recently some tetracyclic β-carbolines have been described to act as selective inhibitors in the anticancer field [8–9], or to be endowed with antimalarial properties [10].…”

Section: Introductionmentioning

confidence: 99%

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure

Airaghi¹,

Fiorati²,

Lesma³

et al. 2013

Beilstein J. Org. Chem.

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SummaryAiming at restricting the conformational freedom of tryptophan-containing peptide ligands, we designed a THBC (tetrahydro-β-carboline)-DKP (diketopiperazine)-based peptidomimetic scaffold capable of arranging in an unusual α-turn conformation. The synthesis is based on a diastereoselective Pictet–Spengler condensation to give the THBC core, followed by an intramolecular lactamization to complete the tetracyclic THBC-DKP fused ring system. The presence of conformers bearing the intramolecular thirteen-membered hydrogen bond that characterizes the α-turn structure is confirmed by 1H NMR conformational studies. To the best of our knowledge, this scaffold represents one of the rare examples of a designed constrained α-turn mimic.

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“…In this way, iproniazid, the earliest reported M A 0 inhibitor to possess in vivo efficiency, was given a central role in neurochemical and psychopharmacological research. Zeller and others [1,3] showed the clinical potential of this compound for the treatment of mental depression.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical study of iproniazid and its analytical determination by differential pulse polarography

et al. 1994

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Iproniazid was found to be irreversibly reduced in two steps, involving the exchange of two electrons and two protons each, by using tast polarography, normal pulse polarography (NPP), and cyclic voltammetry (a7). The rate constants of these two steps were found to be 5.8 x and 4.2 X and 4.2 X cm s -I , respectively, and their corresponding diffusion coefficients 4.5 X lo-' and 8.3 X lo-' cm' s-I. Also, a, the coefficient of cathodic transfer, m7as found to be 0.20 to 0.25 for the first peak and 0.17 to 0.15 for the second. On the basis of the electrochemical study performed, a differential pulse polarographic method for the determination of iproniazid over the concentration range of j X 10-M to 1 X lo-' M was developed.

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Monoamine Oxidase Inhibitors

Cited by 71 publications

References 125 publications

Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness

Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure

Electrochemical study of iproniazid and its analytical determination by differential pulse polarography

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