2006
DOI: 10.1016/j.brainres.2006.06.008
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Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes

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Cited by 82 publications
(23 citation statements)
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“…In addition, the activation of monoaminergic transmitter receptors, coupled to cAMP production and CREB activation, can induce BDNF gene transcription 46. The foregoing findings suggest the involvement of monoaminergic systems in the regulation of BDNF production 43. NT-3 may also increase under stress conditions by the same mechanism as BDNF.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…In addition, the activation of monoaminergic transmitter receptors, coupled to cAMP production and CREB activation, can induce BDNF gene transcription 46. The foregoing findings suggest the involvement of monoaminergic systems in the regulation of BDNF production 43. NT-3 may also increase under stress conditions by the same mechanism as BDNF.…”
Section: Discussionmentioning
confidence: 97%
“…Several studies have shown that increased levels of monoaminergic neurotransmitters, including adrenaline, noradrenaline, serotonin, and dopamine, induce BDNF expression in the brain under stress conditions 42-44. Monoaminergic neurotransmitters have also been found to be able to potently and transiently increase BDNF cellular content in rat neonatal astrocytes in vitro 43,45. In addition, the activation of monoaminergic transmitter receptors, coupled to cAMP production and CREB activation, can induce BDNF gene transcription 46.…”
Section: Discussionmentioning
confidence: 99%
“…NE reduces neuroinflammation (Feinstein et al, 2002), helps ameliorate amyloid cellular toxicity (Counts and Mufson, 2010), and protects cultured neurons from metabolic (Madrigal et al, 2009) and oxidative stress (Troadec et al, 2001). LC-NE activation can increase BDNF production (Jurič et al, 2006) and hippocampal neurogenesis (Kulkarni et al, 2002; Masuda et al, 2012; Veyrac et al, 2009)–both of which promote healthy cognitive and memory function. Exploration of novel environments, one form of mental stimulation, activates the LC (Kitchigina et al, 1997; Sara et al, 1994) and enhances memory via an adrenergic mechanism (Straube et al, 2003; Veyrac et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…The noradrenergic system may also influence BDNF expression (Haenisch et al 2009; Chen and Russo-Neustadt 2007, Chen et al 2007; Juric et al 2006; Garcia et al 2003). It has been reported that norepinephrine (NE) locally applied to hippocampal neurons can enhance the expression of BDNF in a time- and dose-dependent manner (Chen and Russo-Neustadt, 2007; Chen et al 2007).…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that norepinephrine (NE) locally applied to hippocampal neurons can enhance the expression of BDNF in a time- and dose-dependent manner (Chen and Russo-Neustadt, 2007; Chen et al 2007). NE may also transiently increase BDNF in cultured cortical and cerebellar astrocytes (Juric et al 2006). In a study involving knockout mice it was observed that norepinephrine transporter knockout mice are resistant to stress induced depressive like behaviors as well as stress induced reduction of BDNF levels (Haenisch et al 2009).…”
Section: Discussionmentioning
confidence: 99%