Monoclonal and biclonal gammopathy in two patients infected with Bartonella henselae

Krause, Robert; Auner, Holger W.; Daxböck, Florian; A, Mulabecirovic; Krejs, G. J.; Wenisch, Christoph; Reisinger, Emil C.

doi:10.1007/s00277-003-0675-4

Cited by 14 publications

(19 citation statements)

References 19 publications

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“…HSP is an immune-mediated vasculitis that is characterized by excessive IgA production and frequently associated with thrombocytopenia. Monoclonal and biclonal [125] gammopathy in two patients infected with Bartonella henselae has also been described [140]. Bartonella have also been suggested as a cause of granulum annulare [211] and glomerulonephritis associated with negative culture endocarditis [223].…”

Section: Humansmentioning

confidence: 99%

Factors associated with the rapid emergence of zoonotic Bartonella infections

et al. 2005

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-The present manuscript reviews the factors associated with the emergence of these zoonotic pathogens, including better diagnostic tools and methods to identify these fastidious bacteria, host immunosuppression (caused by infectious agents, cancer, aging or induced by immunosuppressive drugs), the interaction of co-infection by several infectious agents that may enhanced the pathogenecity of these bacteria, increased outdoor activity leading to exposure to wildlife reservoirs or vectors, poverty and low income associated with infestation by various ectoparasites, such as body lice and finally the dispersal of Bartonellae around the world. Furthermore, a description of the main epidemiological and clinical features of zoonotic Bartonellae is given. Finally, the main means for diagnosis, treatment and prevention of these diseases are presented.

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Section: Humansmentioning

confidence: 99%

Factors associated with the rapid emergence of zoonotic Bartonella infections

et al. 2005

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“…Monoclonal and biclonal gammopathies in 2 patients infected with B henselae have also been recently detected. 90 Bartonella spp have also been suggested as a cause of granuloma annulare 91 and glomerulonephritis. 92 Bartonella spp were first described as a cause of endocarditis in humans in 3 reports in 1993: endocarditis was caused by B quintana in 1 immunocompromised individual, 93 caused by B elizabethae in an immunocompetent patient, 94 and caused by B (Rochalimaea) henselae in a third individual.…”

Section: Clinical Featuresmentioning

confidence: 99%

Cat scratch disease and other zoonotic Bartonella infections

Chomel¹,

Boulouis²,

Breitschwerdt³

2004

javma

146

183

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“…and hematuria and lymphocytosis . Hyperglobulinemia, including monoclonal and biclonal gammopathies, has been documented in some people with bartonellosis, in a cat with osteomyelitis caused by B. vinsonii , and in a cat with B. henselae associated endocarditis …”

mentioning

confidence: 99%

BartonellaSpecies Antibodies and Hyperglobulinemia in Privately Owned Cats

Whittemore

Hawley

Radecki³

et al. 2012

Veterinary Internal Medicne

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Background Bartonella species are zoonotic agents and primary pathogens in cats. Hyperglobulinemia has been associated with bartonellosis in humans and cats. Hypothesis/Objectives To evaluate for associations between Bartonella species immunoglobulin G (IgG) antibodies and serum biochemistry panel results in privately owned cats. Animals 1,477 privately owned cats. Methods Residual sera were collected after biochemical evaluation for this prospective, cross‐sectional serosurvey. Bartonella species IgG ELISA was performed with a cutoff value of ≥1 : 64. Stepwise logistic regression analysis was performed with the endpoint titer as the outcome variable. The final statistical model included age, albumin, ALP activity, ALT activity, bilirubin, creatinine, glucose, and globulin as covariates. Serum protein electrophoresis was performed with serum from 50 cats with and without antibodies to Bartonella species and hyperglobulinemia. Sera from cats seropositive to Bartonella species and with hyperglobulinemia were assessed for evidence of exposure to other infectious agents associated with hyperglobulinemia. Results Risk of seropositivity to Bartonella species was positively associated with the natural log of globulin concentration (OR = 11.90, 95% CI 6.15–23.02, P < .0001), and inversely associated with the natural log of glucose concentration (OR = 0.66, 95% CI 0.50–0.87, P = .004). Another explanation for hyperglobulinemia was not identified for most cats with Bartonella species antibodies. Hyperglobulinemia was primarily caused by polyclonal gammopathy in cats that were seronegative and seropositive for Bartonella species. Conclusions and Clinical Importance Hyperglobulinemia was significantly associated with seropositivity to Bartonella species. Testing for bartonellosis is warranted in cats with unexplained hyperglobulinemia and clinical or laboratory findings suggestive of bartonellosis.

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Monoclonal and biclonal gammopathy in two patients infected with Bartonella henselae

Cited by 14 publications

References 19 publications

Factors associated with the rapid emergence of zoonotic Bartonella infections

Factors associated with the rapid emergence of zoonotic Bartonella infections

Cat scratch disease and other zoonotic Bartonella infections

BartonellaSpecies Antibodies and Hyperglobulinemia in Privately Owned Cats

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