Monoclonal antibodies against keratins bind to intercalated duct and ductal basal cells of normal salivary glands in paraffin sections.

Heterogeneity of keratin distribution as revealed by monoclonal antibodies in salivary pleomorphic adenomas.

“…Immunohistochemically , positive staining for keratin proteins in ductal basal cells has previously been reported in rodents , domestic animals and humans with the use of polyclonal antikeratin antiserum (25) (13), and 312C8-1 and 8 .12 (12). The biologic significance of ductal basal cells might be related to either differentiation or neoplastic transformation (26) . Furthermore, the question persists whether or not the progenitor cell for pleomorphic adenomas corresponds to ductal basal (reserve) cell .…”

Biologically active peptides in the submandibular gland. Role of the granular convoluted tubule.

“…Ductal Basal Cell: Ductal Basal Cells in striated and excretory ducts of human salivary glands have been estimated in terms of keratin immunohistochemistry (38,50,81,84), and these basal cells also have important stem cells in neoplastic transformation of pleomorphic adenomas (72,95) tion with secretion of calcitonin. Other Factors: It has been reported that salivary glands in human and animals contain and secrete other growth factors and other growth factor-related substances identified by biological and biochemical studies, however cellular origin of these substances in salivary glands is still unknown.…”

Warthin's Tumour of the Parotid Glands, Adenomatous Hyperplasia and Oncocytic Adenomatous Hyperplasia of the Intranodal Heterotopic Salivary Glands: A Comparative Immunohistochemical Assessment.

“…In the ductal epithelium of normal salivary glands, the antibodies K8.12, PKK1 and KL1 were reactive with the luminal and basal cells in the intercalated, striated and excretory ducts with different reaction intensities. The immunoreactivity of antibody K8.12 was predominantly present in the basal cells, while that of antibodies PKK1 and KL1 was equally present in the luminal and basal cells [3,8,29,39,41]. In prenatally developing salivary glands, ductal basal cells have been found to be similar to those found in the adult glands with respect to the expression of cytokeratins detected by antibodies K8.12 and PKK1 which appears relatively early during the differentiation of larger ducts [21].…”

“…The cytokeratins detected by antibodies K8.12, PKK1 and KL1 have been consistently demonstrated in normal and neoplastic lesions of the salivary glands [3,8,12,23,39,41]. In the ductal epithelium of normal salivary glands, the antibodies K8.12, PKK1 and KL1 were reactive with the luminal and basal cells in the intercalated, striated and excretory ducts with different reaction intensities.…”