Monocyte chemoattractant protein-1 (MCP-1) and macrophage infiltration into the skin after burn injury in aged mice

Chemokines and Their Receptors Are Key Players in the Orchestra That Regulates Wound Healing

“…It has been known for some time that young and aged burned mice show an increase in CCL2 at 1 day postburn. 155 It has also been shown that CXCL12 is expressed in the hair follicles and endothelial cells of the blood vessels in the area of the burn and in the eosinophils and mononuclear cells found in the wound bed. 156 Blocking CXCL12 resulted in improved healing with diminished inflammation and improved re-epithelialization.…”

Protection of burn-induced skin injuries by the flavonoid kaempferol

“…The exposure of skin tissue to thermal burns is known to preferentially induce augmented recruitment of neutrophils and macrophages (5)(6)(7)(8), T lymphocyte dysfunction (9,10), production of Th2 cytokine profiles such as IL-4 and IL-10 (11), production of chemokines such as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) (8,12), and expression of inflammatory mediators (13,14). Researchers have shown that the neutrophil chemoattractant genes KC (GROα) and MIP-2 are expressed in different cell populations at sites of surgical injury in the skin (8).…”

“…Researchers have shown that the neutrophil chemoattractant genes KC (GROα) and MIP-2 are expressed in different cell populations at sites of surgical injury in the skin (8). Further, Shallo et al, have reported that thermal injury to mouse skin upregulates the expression of MCP-1, leading to infiltration of macrophages into the skin (12). Evidence has been presented that thermal injury leads to production of inflammatory cytokines such as TNF-α, IL-4, and IL-6, and these cytokines have been shown to play roles in the development of life-threatening post-burn complications such as multiple organ failure (1)(2)(3)(4)15).…”

Remodeling of the immunoinflammatory network system in elderly cancer patients: Implications of inflamm-aging and tumor-specific hyperinflammation

“…71 Interestingly, several experimental studies have shown that macrophages from aged mice produce less growth factors such as monocyte chemoattractant protein-1 and vascular endothelial cell growth factor, which induce wound re-epithelialization and angiogenesis, than macrophages from young mice, although the production of these growth factors is stimulated by proinfl ammatory cytokines. 72,73 …”