1997
DOI: 10.1074/jbc.272.18.11682
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Monocyte Chemotactic Protein-2 (MCP-2) Uses CCR1 AND CCR2B as Its Functional Receptors

Abstract: Monocyte chemotactic protein (MCP)-

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Cited by 124 publications
(85 citation statements)
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“…C5a (through the C5aR receptor) and CXCL5/CXCL2 (through the CXCR2 receptor) are primarily chemoattractants for neutrophils, 22,23 although they are also involved in T-cell migration to the intestinal mucosa 24 and to the brain, 25,26 whereas CCL5 and CCL8 can attract monocytes, NK cells, and activated T cells (through CCR5 and CCR1 receptors). [27][28][29] However, our data show a lower or similar percentage of C5aR-, CXCR2-, CCR1-, and CCR5-expressing CD8 T cells in the bladder with or without IVES Ty21a immunostimulation, suggesting an indirect effect of the cognate chemokines on the preferential increase in CD8 T cells in the bladder.…”
Section: Discussioncontrasting
confidence: 47%
“…C5a (through the C5aR receptor) and CXCL5/CXCL2 (through the CXCR2 receptor) are primarily chemoattractants for neutrophils, 22,23 although they are also involved in T-cell migration to the intestinal mucosa 24 and to the brain, 25,26 whereas CCL5 and CCL8 can attract monocytes, NK cells, and activated T cells (through CCR5 and CCR1 receptors). [27][28][29] However, our data show a lower or similar percentage of C5aR-, CXCR2-, CCR1-, and CCR5-expressing CD8 T cells in the bladder with or without IVES Ty21a immunostimulation, suggesting an indirect effect of the cognate chemokines on the preferential increase in CD8 T cells in the bladder.…”
Section: Discussioncontrasting
confidence: 47%
“…Since deletion of CCR2 did not affect virus levels in the brain, it is probable that the effect of CCR2 on Fr98-mediated neurological disease was due to chemokine binding and signaling through CCR2. CCR2 binds several chemokines, primarily MCP-1, MCP-2, MCP-3, and MCP-5 (3,11,30). We were therefore interested in determining if the expression of these genes was upregulated by Fr98 infection and if any of these genes were upregulated prior to disease onset.…”
Section: Resultsmentioning
confidence: 99%
“…Expression of CCR2 is inhibited in monocytes and T cells by LPS and IFN-␥ (35,36) and up-regulated by IL-2, IL-4, IL-10, and IL-12 in T cells (35). Although MCP-1 is the principal ligand for CCR2, other ligands include MCP-2, MCP-3, MCP-4, MCP-5, and HIV Tat (37)(38)(39)(40)(41). However, in mice, only MCP-1, MCP-3, and MCP-5 bind CCR2.…”
Section: Ccr2 ϫ/ϫ Mice Are Protected From Pulmonary Fibrosismentioning
confidence: 99%