2021
DOI: 10.1038/s41598-021-92236-6
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Monocyte Distribution Width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patients

Abstract: Monocyte Distribution Width (MDW), a new cytometric parameter correlating with cytomorphologic changes occurring upon massive monocyte activation, has recently emerged as promising early biomarker of sepsis. Similar to sepsis, monocyte/macrophage subsets are considered key mediators of the life-threatening hyper-inflammatory disorder characterizing severe COVID-19. In this study, we longitudinally analyzed MDW values in a cohort of 87 COVID-19 patients consecutively admitted to our hospital, showing significan… Show more

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Cited by 46 publications
(37 citation statements)
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“…Although prior studies have separately evaluated MDW and NLR as biomarkers for COVID‐19 prognostication, ours is the first to evaluate the value of both biomarkers together. 6 , 10 The immune response to severe COVID‐19 is associated with dysregulated expression of IL‐7 and IL‐10, as well as increased neutrophil conductivity thought be reflected in elevations of both the NLR and MDW. 8 While the MDW measure is Food and Drug Administration approved as an early sepsis indicator in adults presenting to the ED setting, its use is not ubiquitous.…”
Section: Tablementioning
confidence: 99%
“…Although prior studies have separately evaluated MDW and NLR as biomarkers for COVID‐19 prognostication, ours is the first to evaluate the value of both biomarkers together. 6 , 10 The immune response to severe COVID‐19 is associated with dysregulated expression of IL‐7 and IL‐10, as well as increased neutrophil conductivity thought be reflected in elevations of both the NLR and MDW. 8 While the MDW measure is Food and Drug Administration approved as an early sepsis indicator in adults presenting to the ED setting, its use is not ubiquitous.…”
Section: Tablementioning
confidence: 99%
“…Among the various inflammatory cytokine and chemokine levels assessed in several studies, tumor necrosis factor alpha (TNF-α), interferon-γ-induced protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), chemokine (C-C motif), ligand 3 (CCL-3), and distinct interleukins (IL) (IL-2, IL-6, IL-7, IL-10) have been shown to be significantly associated with disease severity, and in particular, elevated in patients admitted to intensive care units (ICUs) [ 5 ]. New cytometric parameters, such as Monocyte Distribution Width (MDW) and Neutrophil-to-Lymphocyte Ratio (NLR), were recently found to correlate well with the clinical severity of COVID-19-associated inflammatory disorder [ 6 , 7 ]. Notably, the serum levels of some interleukins have the potential to discriminate between mild and severe disease, and can possibly be used as prognostic markers [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
“… 2 Intriguingly, by providing a conceptual link between the diagnosis of sepsis and COVID-19, MDW findings can further support the notion that severe COVID-19 may constitute a (new) kind of viral sepsis. 3 Moreover, recent pilot studies have disclosed that MDW testing may also be exploited for prognostic monitoring in hospitalized COVID-19 patients, either alone, 4 or in combination with Neutrophil-to-Lymphocyte Ratio (NLR). 5 …”
mentioning
confidence: 99%
“…The novel haematological parameter MDW, already described as early sepsis biomarker in ED and ICU settings, can well correlate with COVID-19-related systemic inflammation, disease severity and outcome. 4 Here, three risk groups ( low, intermediate and high MDW ) are identified on the basis of reported MDW cutoffs. 2 , 4 , 5 …”
mentioning
confidence: 99%
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