Monocyte to high‐density lipoprotein cholesterol ratio as an independent risk factor for papillary thyroid carcinoma

Abstract

Background Papillary thyroid carcinoma (PTC) is considered to be an inflammatory disease. This study aimed to investigate the association of monocyte to high‐density lipoprotein cholesterol ratio (MHR) with PTC. Methods Clinical parameters from 300 patients with PTC and 552 patients with benign thyroid nodule were compared. Serum renal function and liver enzymes, fasting plasma glucose, lipid profile, and blood cell count were measured. Results Patients with PTC had a higher MONO (p < 0.001) and MHR (p < 0.001). There was a step‐wise increase in the prevalence of PTC (p = 0.003) with the tertile of MHR. Logistic regression analysis revealed that MHR could be considered an independent risk factor (p < 0.001) in the case‐control study and the cohort study. Pearson correlation analysis and simple linear regression analysis indicated that MHR was positively associated with neutrophil (NEU) and lymphocyte (LYM) count as well as neutrophil‐to‐lymphocyte ratio (NLR). Area under the curve (AUC) was 0.711. The optimal cutoff of MHR was 0.33 × 109/mmol. Conclusion This study identifies novel evidence that patients with PTC have a higher MHR. MHR is an independent risk factor for PTC. These findings support the application of MHR to predict, diagnose, and evaluate the occurrence of PTC.

Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS Cohort

“…Corroborating our study, the three cohort studies all showed an association between a lower level of HDL-C and a higher risk of thyroid cancer [8,11,29]. Among the cross-sectional or case-control studies, a lower level of HDL-C was reported among cases of thyroid cancer, compared to controls, in four studies [10,18,20,21], although not all differences were statistically significant. However, no difference was noted between cases and controls in the other five studies [13,15,22,24,25].…”

“…The cohort study did not find a statistically significant association between per quintile increase in TC and risk of thyroid cancer among either men or women [17]. Among the cross-sectional or case-control studies, six reported a lower level of TC [14,18,20,21,24,25], whereas three reported a similar or higher level of TC [16,22,26] among cases with thyroid cancer, compared to controls. Some of the studies [18,22,25,26] were relatively small, making random finding a potential concern.…”

“…As a structural molecule essential for cell membrane and different biological processes, cholesterol has been proposed to contribute to the development and progression of human cancer [37]. To our best knowledge, one cohort study [17] and nine cross-sectional or case-control studies [14,16,18,[20][21][22][24][25][26] have so far examined the link between TC and risk of thyroid cancer. The cohort study did not find a statistically significant association between per quintile increase in TC and risk of thyroid cancer among either men or women [17].…”

“…HDL-C is known to be protective against cardiovascular disease [38], and a low level of HDL-C has also been suggested to be associated with a higher risk of hematological malignances, cancer in the nervous system, breast cancer, and cancer in the respiratory system [39]. We identified three cohort studies [8,11,29] and nine cross-sectional or case-control studies [10,13,15,18,[20][21][22]24,25] that examined a link between HDL-C and risk of thyroid cancer. Corroborating our study, the three cohort studies all showed an association between a lower level of HDL-C and a higher risk of thyroid cancer [8,11,29].…”

Monocyte to High‐density Lipoprotein Cholesterol Ratio (MHR) as a Predictor of the Activity of Thyroid-associated Ophthalmopathy (TAO)

“…However, there are few studies exploring the function of MHR in thyroid disorders. Recently, several reports have declared that MHR is closely linked to papillary thyroid carcinoma as well as thyroid nodule [25,26] . So far, no reports on the correlation between MHR and TAO have been published.…”