Monocyte-to-high-density lipoprotein cholesterol ratio is associated with the presence and size of thyroid nodule irrespective of the gender

Liu, Xing Zhen; Wang, Jun Min; Ji, Yi Xin; Zhao, Dong

doi:10.1186/s12944-020-1196-z

Cited by 14 publications

(12 citation statements)

References 39 publications

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“…Nonetheless rarely has MHR been studied in thyroid disease. One large‐scale study reported that MHR level was significantly increased in patients with thyroid nodules; MHR was significantly associated with the presence of thyroid nodule and strongly associated with the presence and size of thyroid nodule irrespective of gender 34 . There has been no report of a correlation between MHR and PTC.…”

Section: Discussionmentioning

confidence: 99%

“…One large‐scale study reported that MHR level was significantly increased in patients with thyroid nodules; MHR was significantly associated with the presence of thyroid nodule and strongly associated with the presence and size of thyroid nodule irrespective of gender. 34 There has been no report of a correlation between MHR and PTC. Our study confirmed our hypothesis that MHR was significantly increased in and closely related to PTC and an independent risk factor for PTC.…”

Section: Discussionmentioning

confidence: 99%

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Monocyte to high‐density lipoprotein cholesterol ratio as an independent risk factor for papillary thyroid carcinoma

Pang

et al. 2021

Clinical Laboratory Analysis

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Background Papillary thyroid carcinoma (PTC) is considered to be an inflammatory disease. This study aimed to investigate the association of monocyte to high‐density lipoprotein cholesterol ratio (MHR) with PTC. Methods Clinical parameters from 300 patients with PTC and 552 patients with benign thyroid nodule were compared. Serum renal function and liver enzymes, fasting plasma glucose, lipid profile, and blood cell count were measured. Results Patients with PTC had a higher MONO (p < 0.001) and MHR (p < 0.001). There was a step‐wise increase in the prevalence of PTC (p = 0.003) with the tertile of MHR. Logistic regression analysis revealed that MHR could be considered an independent risk factor (p < 0.001) in the case‐control study and the cohort study. Pearson correlation analysis and simple linear regression analysis indicated that MHR was positively associated with neutrophil (NEU) and lymphocyte (LYM) count as well as neutrophil‐to‐lymphocyte ratio (NLR). Area under the curve (AUC) was 0.711. The optimal cutoff of MHR was 0.33 × 109/mmol. Conclusion This study identifies novel evidence that patients with PTC have a higher MHR. MHR is an independent risk factor for PTC. These findings support the application of MHR to predict, diagnose, and evaluate the occurrence of PTC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Monocyte to high‐density lipoprotein cholesterol ratio as an independent risk factor for papillary thyroid carcinoma

Pang

et al. 2021

Clinical Laboratory Analysis

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“…Molecular mimicry is considered a possible mechanism underlying the relationship between H. pylori infection and pathophysiology mechanisms of thyroid diseases. In fact, previous evidence has suggested that infection-induced chronic inflammation could be a crucial cause of TN types, which may also be related to the structural similarity between H. pylori epitope antigen and thyroid autoantigen ( Yu et al., 2019 ; Liu et al., 2020 ). It has been reported that 14 proteins of H. pylori antigen epitope are similar to thyroid endogenous proteins, including the segments of human thyrotropin receptor, thyroid autoantigen, and sodium iodide symporter ( Benvenga and Guarneri, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Lack of Association Between Helicobacter pylori Infection and the Risk of Thyroid Nodule Types: A Multicenter Case-Control Studyin China

Wang

Jiang

et al. 2021

Front. Cell. Infect. Microbiol.

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The prevalence of Helicobacter pylori infection is high worldwide, while numerous research has focused on unraveling the relationship between H. pylori infection and extragastric diseases. Although H. pylori infection has been associated with thyroid diseases, including thyroid nodule (TN), the relationship has mainly focused on potential physiological mechanisms and has not been validated by large population epidemiological investigations. Therefore, we thus designed a case-control study comprising participants who received regular health examination between 2017 and 2019. The cases and controls were diagnosed via ultrasound, while TN types were classified according to the guidelines of the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS). Moreover, H. pylori infection was determined by C14 urea breath test, while its relationship with TN type risk and severity was analyzed using binary and ordinal logistic regression analyses. A total of 43,411 participants, including 13,036 TN patients and 30,375 controls, were finally recruited in the study. The crude odds ratio (OR) was 1.07 in Model 1 (95% CI = 1.03–1.14) without adjustment compared to the H. pylori non-infection group. However, it was negative in Model 2 (OR = 1.02, 95% CI = 0.97–1.06) after being adjusted for gender, age, body mass index (BMI), and blood pressure and in Model 3 (OR = 1.01, 95% CI = 0.97–1.06) after being adjusted for total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein on the basis of Model 2. Control variables, including gender, age, BMI, and diastolic pressure, were significantly correlated with the risk of TN types. Additionally, ordinal logistic regression results revealed that H. pylori infection was positively correlated with malignant differentiation of TN (Model 1: OR = 1.06, 95% CI = 1.02–1.11), while Model 2 and Model 3 showed negative results (Model 2: OR = 1.01, 95% CI = 0.96–1.06; Model 3: OR = 1.01, 95% CI = 0.96–1.05). In conclusion, H. pylori infection was not significantly associated with both TN type risk and severity of its malignant differentiation. These findings provide relevant insights for correcting possible misconceptions regarding TN type pathogenesis and will help guide optimization of therapeutic strategies for thyroid diseases.

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“…The production of inflammatory cytokines from thyroid-infiltrating mononuclear and follicular cells was associated with Graves disease [18]. Systemic inflammation defined by monocyte-to-high-density-lipoprotein-cholesterol ratio (MHR) might be involved in the development of thyroid nodules (T.N.s) [19]. Leukocytic infiltration mainly constituted by macrophages (inflammation) was normal in transgenic mice expressing RET/PTC3 (RP3, an oncogenic fusion protein in the thyroid gland), with papillary thyroid carcinoma (PTC)-like lesions [20].…”

Section: Introductionmentioning

confidence: 99%

The Association between the Dietary Inflammatory Index and Thyroid Function in U.S. Adult Males

Liu

Feng

et al. 2021

Nutrients

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Thyroid function has a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential is associated with thyroid function. We aimed to assess the relationship among them using the data from the National Health and Nutrition Examination Survey (NHANES). This study was a cross-sectional study, where weighted multivariable linear regression, subgroup analyses, and interaction terms were employed. Thyroid function was assessed by eight indexes, including total and free T4 and T3, Tg, TgAb, TPOAb, and TSH. A total of 2346 male participants aged ≥20 years with an average age of 50.74 ± 17.68 years were enrolled. The mean DII score among participants was −0.46 ± 1.73, ranging from −4.12 to 4.41, and mean total thyroxine (T4) was 7.61 ± 1.51 μg/dL. We found a positive association between DII and total T4 (β = 0.07; p = 0.0044). Using subgroup analysis, this association became stronger in both the iodine-deficient and obese group (iodine-deficient group: β = 0.15, p < 0.0001; obese group: β = 0.14, p < 0.0001). In conclusion, men adhering to a more pro-inflammatory diet appeared to have higher total T4 levels. However, these hormone variations were still within the normal clinical range and more well-designed studies are still needed to validate the causal relationship between DII and thyroid function.

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Monocyte-to-high-density lipoprotein cholesterol ratio is associated with the presence and size of thyroid nodule irrespective of the gender

Cited by 14 publications

References 39 publications

Monocyte to high‐density lipoprotein cholesterol ratio as an independent risk factor for papillary thyroid carcinoma

Monocyte to high‐density lipoprotein cholesterol ratio as an independent risk factor for papillary thyroid carcinoma

Lack of Association Between Helicobacter pylori Infection and the Risk of Thyroid Nodule Types: A Multicenter Case-Control Studyin China

The Association between the Dietary Inflammatory Index and Thyroid Function in U.S. Adult Males

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