Monocyte to high-density lipoprotein ratio predict long-term clinical outcomes in patients with coronary heart disease: A meta-analysis of 9 studies

Abstract

Background: A novel inflammation-related biomarker, the monocyte to high-density lipoprotein cholesterol ratio (MHR), had a great relation to the development and prognosis of coronary atherosclerotic heart disease. Current study was to investigate whether the MHR was a potential tool in predicting the mortality and major adverse cardiac events (MACEs) in patients suffering coronary heart disease (CHD) by meta-analysis.Methods: The Cochrane Library, PubMed, MEDLINE, Scopus, EMBASE, and Web of science were searched for relevant cohort studies published prior to February 10, 2022. The association between MHR and mortality/MACEs was analyzed in patients with CHD. Hazard ratios (HR) with 95% confidence interval (CI) were calculated to estimate the strength of association.Results: In the meta-analysis, a total of 9 studies of 11,345 patients with CHD were included. Compared with the low level of MHR group, the high MHR value was associated with higher long-term MACEs (HR = 1.72 95% CI 1.36-2.18, P < .001), long-term mortality (HR = 1.71, 95% CI 1.10-2.66, P = .017), and in-hospital mortality/MACEs (HR = 2.82, 95% CI = 1.07-7.41, P = .036).Conclusions: This study suggested that increased MHR value might be associated with higher long-term mortality and longterm MACEs in CHD patients. MHR might serve as a potential prognostic indicator for risk stratification in patients with CHD.Abbreviations: CAD = coronary artery disease, CHD = coronary heart disease, CI = confidence interval, HDL = High-density lipoprotein, HDL-C = HDL-cholesterol, HR = Hazard ratios, MACEs = major adverse cardiac events, MHR = monocyte to highdensity lipoprotein cholesterol ratio, NOS = New Castle-Ottawa scale, PRISMA = preferred reporting items for systematic reviews and meta-analyses, STEMI = ST-segment elevation myocardial infarction.

İskemik İnmenin Etyolojiye Göre Alt Gruplarında Monosit/Hdl-K Oranlarının Karşılaştırılması

“…A meta-analysis study evaluating the relationship of MHR to survival in cardiac diseases in large patient groups shows that increased MHR is associated with higher long-term mortality and increased major cardiac adverse events in coronary heart disease. It indicates that MHR may serve as a potential prognostic indicator for risk stratification in this patient group (14).…”

“…Preoperative MHR elevation may be an important biomarker to predict early recurrence after atrial fibrillation ablation (12). Increased MHR may predict the risk of developing intra-stent restenosis after coronary angiography, and may be associated with higher long-term mortality and long-term major cardiac adverse events in patients with coronary heart disease (13,14).…”

Monocyte to high‐density lipoprotein ratio predicts clinical outcomes after acute ischemic stroke or transient ischemic attack

“…Another prospective observational study suggested that MHR was an independent predictor of major adverse cardiovascular events' occurrence in patients undergoing coronary angiography 16 . Recently, a meta‐analysis that involved 9 studies indicated that for patients with coronary heart disease, increased MHR value might be associated with higher long‐term mortality and major adverse cardiovascular events 26 . Nevertheless, some studies have explored the relationship between MHR and short‐term stroke prognosis based on small sample size data from one single center but reported inconsistent results for hemorrhagic transformation 27,28 and for all‐cause mortality 20,22 .…”

The monocyte to high-density lipoprotein cholesterol ratio is positively associated with the severity of coronary artery disease in patients with nonalcoholic fatty liver disease

“…Li et al [41] proved that elevated MHR levels are associated with in-hospital MACE and longterm bleeding events in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients undergoing PCI. A meta-analysis of 11,345 CHD patients included 9 studies [42] showed that high levels of MHR may be associated with higher long-term mortality and long-term MACE in CHD patients. In addition, MHR currently not only related to CVD.…”