Monocytes in the Rat

Scriba, Andreas; Stehling, Oliver; Steiniger, Birte

doi:10.1016/s0171-2985(00)80056-x

Cited by 34 publications

(22 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Physical parameters and the expression of cell surface markers, known to be differentially regulated by monocytes (Grau et al, 2000;Steiniger et al, 2001), were analysed by flow cytometry. Cell size and granularity were increased in allograft monocytes (Fig.…”

Section: Phenotype Of Intravascular Graft Monocytes On Daymentioning

confidence: 99%

Leukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys

et al. 2011

Self Cite

View full text Add to dashboard Cite

Section: Phenotype Of Intravascular Graft Monocytes On Daymentioning

confidence: 99%

Leukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys

et al. 2011

Self Cite

View full text Add to dashboard Cite

“…In an additional group of rats (n ϭ 18 total), circulating ED1 ϩ monocytes, which are the precursors of tissue macrophages, were analyzed in sodium-restricted and controlfed rats at day 2 postsection (Grau et al, 2000). Whole blood was collected by cardiac puncture into EDTAcontaining vacutainers (Becton Dickinson, San Jose, CA).…”

Section: Flow Cytometrymentioning

confidence: 99%

“…Additional experiments examined whether the lowsodium diet reduces the number of circulating monocytes, which are precursors to activated macrophages and share the ED1 ϩ phenotype (Grau et al, 2000). In other words, are activated macrophages decreased in the tongue in sodium-restricted rats because the pool of circulating monocytes available for entry has been depleted?…”

Section: Effect Of Denervation and Dietary Sodium Restriction On Extrmentioning

confidence: 99%

Up‐regulation of activated macrophages in response to degeneration in the taste system: Effects of dietary sodium restriction

McCluskey

2004

J of Comparative Neurology

View full text Add to dashboard Cite

Dietary sodium restriction combined with unilateral chorda tympani nerve section leads to a rapid and specific decrease in neurophysiological taste responses to sodium in the contralateral, intact chorda tympani (Hill and Phillips [1994] J. Neurosci. 14:2904-2910). Previous work demonstrated that dietary sodium restriction may induce these early functional deficits by inhibiting immune activity after denervation (Phillips and Hill [1996] Am. J. Physiol. 271:R857-R862). However, little is known about the leukocyte response to denervation of taste buds in fungiform papillae. In the current study, it was hypothesized that T cells and macrophages are increased in the tongue after unilateral denervation in control-fed but not sodium-restricted animals. Adult, specified pathogen-free rats received unilateral chorda tympani nerve section or sham section followed by dietary sodium restriction or maintenance on control diet. At day 1, 2, 5, 7, or 50 postsectioning, immunostaining was used to detect the percentage of staining for activated macrophages, the number of alpha beta T cells, and the number of delta gamma epithelial T cells in the tongue. The number of lingual T cells did not significantly differ between treatment groups following denervation. However, there was a dramatic bilateral increase in ED1(+) staining for activated macrophages in control-fed rats that peaked at day 2 postsectioning. In contrast, sodium-restricted rats did not show an increase in activated macrophages above baseline at any time postsectioning. Further analysis of extralingual macrophages indicated that the deficit in immune activity in sodium-restricted rats is localized to the tongue and is not widespread. A model for immune modulation of taste receptor cell function is proposed based on these novel findings.

show abstract

“…10/78 ? ) as activated monocytes [30]. In this population, similar to monocytes, the obese control group showed significantly higher cell numbers than lean control animals.…”

Section: Subset-specific Alterations Of Blood Leukocyte Numbers In Obmentioning

confidence: 84%

Diet-induced obesity, exogenous leptin-, and MADB106 tumor cell challenge affect tissue leukocyte distribution and serum levels of cytokines in F344 rats

Behrendt

Buchenauer

Horn

et al. 2010

Endocr

View full text Add to dashboard Cite

The adipocyte-derived catabolic protein leptin alters cell-mediated immunity and cytokine crosstalk. This may provide new insights into the altered immune response, seen in obese individuals. Therefore, we determined the tissue distribution of immune cells in diet-induced obese (dio) and normal weight F344 rats challenged with MADB106 tumor cells or leptin. Immune cell distribution in blood (by FACS analysis) and tissues (NK cells in spleen and liver, immunohistologically) as well as pro-inflammatory cytokines (IL-6, TNF-α; by flow cytometry) were investigated in 28 normal weight and 28 dio rats (n = 4-6/group). Pro-inflammatory cytokines were increased 3-fold for IL-6 and 7-fold for TNF-α in obese animals. Higher numbers of blood monocytes and NK cells were found in obese as compared to normal weight animals. In dio rats challenged with leptin and MADB106 tumor cells, monocyte numbers were decreased as compared to the obese control animals. Immunohistochemistry revealed an altered NK cell distribution in a compartment-, treatment-, and bodyweight-specific manner. In conclusion, our data reveal a distinct distribution pattern of monocytes and NK cells in dio rats as compared to normal weight littermates and an additional modulatory effect of a leptin- and MADB106 tumor cell challenge.

show abstract

Monocytes in the Rat

Cited by 34 publications

References 20 publications

Leukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys

Leukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys

Up‐regulation of activated macrophages in response to degeneration in the taste system: Effects of dietary sodium restriction

Diet-induced obesity, exogenous leptin-, and MADB106 tumor cell challenge affect tissue leukocyte distribution and serum levels of cytokines in F344 rats

Contact Info

Product

Resources

About