Monodisperse Chitosan Microspheres with Interesting Structures for Protein Drug Delivery

Abstract

Monodisperse chitosan microspheres with different structures are prepared and loaded with proteins, as exemplified in the figure. The different types of microspheres show different protein release profiles, which implies that that their properties can be adjusted to fit the needs of different therapeutic applications. The structural properties of the microspheres are varied by adjusting the surface charge, cavity size, and wall porosity.

pH‐ and Redox‐Responsive Polysaccharide‐Based Microcapsules with Autofluorescence for Biomedical Applications

“…[9][10][11] In particular, due to the dynamic characteristics of Schiff base bonds, pH-responsive microcapsules with autofluorescence are extraordinarily attractive for triggered release. [12][13][14] Meanwhile, disulfide or diselenide bonds can act as the cross-links that can be cleaved to form single thiols or selenols upon reduction of glutathione (GSH). The transition between oxidative and reductive states has been exploited to trigger the destruction or decomposition of drug-delivery systems following cellular uptake, which leads to the development of a wide range of redox-responsive carriers.…”

Metal–organic framework growth at functional interfaces: thin films and composites for diverse applications

“…147,148 Chitosan is a biocompatible polysaccharide 80 bearing terminal amine functionality, which is easily solubilised in acidic media to form a cationic polyelectrolyte permitting its processing into membranes and beads. 149,150 Guari et al have exploited the amine functionality of porous chitosan beads as a scaffold to prepare nanocomposites of magnetic cyano-bridged coordination polymers M 2+ /[Fe(CN 6 )] [3][4][5] (M = Ni, Cu, Co, Fe).…”

Magnetically Triggered Reversible Controlled Drug Delivery from Microfabricated Polymeric Multireservoir Devices

“…Oral delivery is one of the most preferred modes of drug administration; however, the poor oral bioavailability of most therapeutic macromolecules requires the development of alternative methods for drug delivery. [1] Over the past decades, various types of carriers have been developed to achieve controlled drug delivery, including microspheres, [2,3] microcapsules, [4,5] hydrogels, [6,7] microfabricated drug-delivery devices, etc. [8][9][10][11] The demand for efficient drug delivery and administration requires the ability of in situ controlled drug delivery.…”