Monolayer-Capped Gold Nanoparticles for Disease Detection From Breath

Nakhleh, Morad K.; Broza, Yoav Y.; Haick, Hossam

doi:10.2217/nnm.14.121

Cited by 99 publications

(98 citation statements)

References 63 publications

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“…35 Nanotechnology-based chemical sensor matrices based on nanomaterials could serve as the translational tool leading from fundamental research to the modern point-of-care practice. 6,7,22,36−38 This is because chemical sensor matrices are significantly smaller, easier to use, and less expensive than other sensing devices. Basically, recognition of VOCs by nanotechnology-based sensors can be achieved by selective detection of (pre)identified VOCs.…”

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confidence: 99%

Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules

et al. 2016

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We report on an artificially intelligent nanoarray based on molecularly modified gold nanoparticles and a random network of single-walled carbon nanotubes for noninvasive diagnosis and classification of a number of diseases from exhaled breath. The performance of this artificially intelligent nanoarray was clinically assessed on breath samples collected from 1404 subjects having one of 17 different disease conditions included in the study or having no evidence of any disease (healthy controls). Blind experiments showed that 86% accuracy could be achieved with the artificially intelligent nanoarray, allowing both detection and discrimination between the different disease conditions examined. Analysis of the artificially intelligent nanoarray also showed that each disease has its own unique breathprint, and that the presence of one disease would not screen out others. Cluster analysis showed a reasonable classification power of diseases from the same categories. The effect of confounding clinical and environmental factors on the performance of the nanoarray did not significantly alter the obtained results. The diagnosis and classification power of the nanoarray was also validated by an independent analytical technique, i.e., gas chromatography linked with mass spectrometry. This analysis found that 13 exhaled chemical species, called volatile organic compounds, are associated with certain diseases, and the composition of this assembly of volatile organic compounds differs from one disease to another. Overall, these findings could contribute to one of the most important criteria for successful health intervention in the modern era, viz. easy-to-use, inexpensive (affordable), and miniaturized tools that could also be used for personalized screening, diagnosis, and follow-up of a number of diseases, which can clearly be extended by further development.

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Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules

et al. 2016

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“…A promising approach for monitoring the physiological parameters of healthy people is based on the continuous (or frequent) detection of volatile organic compounds (VOCs) [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and/or pressure pulses that are derived from human breath/skin, along with monitoring of heart-beat and breath rate, inter alia. 21,22 This approach has the potential to be painless, easy-to-perform, inexpensive and give results that can be available immediately for therapeutic assessment/diagnosis.…”

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confidence: 99%

“…These ligands were chosen based on previous works showing their utility in clinical diagnosis via VOC samples. 6 After manually scratching the GNP films, the GNP films and polymer substrate were fully damaged and grooves with well-defined dimensions (around 100 µm in width) can be clearly found on the surface of each GNP film ( Figure 2a).…”

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Self-Healable Sensors Based Nanoparticles for Detecting Physiological Markers via Skin and Breath: Toward Disease Prevention via Wearable Devices

Jin

Huynh²,

Haick³

2016

Nano Lett.

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Flexible and wearable electronic sensors are useful for the early diagnosis and monitoring of an individual's health state. Sampling of volatile organic compounds (VOCs) derived from human breath/skin or monitoring abrupt changes in heart-beat/breath rate should allow noninvasive monitoring of disease states at an early stage. Nevertheless, for many reported wearable sensing devices, interaction with the human body leads incidentally to unavoidable scratches and/or mechanical cuts and bring about malfunction of these devices. We now offer proof-of-concept of nanoparticle-based flexible sensor arrays with fascinating self-healing abilities. By integrating a self-healable polymer substrate with 5 kinds of functionalized gold nanoparticle films, a sensor array gives a fast self-healing (<3 h) and attractive healing efficiency in both the substrate and sensing films. The proposed platform was used in sensing pressure variation and 11 kinds of VOCs. The sensor array had satisfactory sensitivity, a low detection limit, and promising discrimination features in monitoring both of VOCs and pressure variation, even after full healing. These results presage a new type of smart sensing device, with a desirable performance in the possible detection and/or clinical application for a number of different purposes.

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“…The most popular are the temperature modulation influencing the rate of adsorption/desorption processes [20], the modifications in the sensor construction, developing new sensor materials (e.g. Au nanoparticle gas sensors for VOC detection [21] nanoparticles increasing the gas sensing active area [22. 23]) or introducing catalytically active additives by bulk doping and surface modification [24].…”

Section: Semiconductor Gas Sensorsmentioning

confidence: 99%

Detection of Gaseous Compounds with Different Techniques

Mikołajczyk

Bielecki

Stacewicz

et al. 2016

Metrology and Measurement Systems

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Sensing technology has been developed for detection of gases in some environmental, industrial, medical, and scientific applications. The main tasks of these works is to enhance performance of gas sensors taking into account their different applicability and scenarios of operation. This paper presents the descriptions, comparison and recent progress in some existing gas sensing technologies. Detailed introduction to optical sensing methods is presented. In a general way, other kinds of various sensors, such as catalytic, thermal conductivity, electrochemical, semiconductor and surface acoustic wave ones, are also presented. Furthermore, this paper focuses on performance of the optical method in detecting biomarkers in the exhaled air. There are discussed some examination results of the constructed devices. The devices operated on the basis of enhanced cavity and wavelength modulation spectroscopies. The experimental data used for analyzing applicability of these different sensing technologies in medical screening. Several suggestions related to future development are also discussed.

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Monolayer-Capped Gold Nanoparticles for Disease Detection From Breath

Cited by 99 publications

References 63 publications

Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules

Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules

Self-Healable Sensors Based Nanoparticles for Detecting Physiological Markers via Skin and Breath: Toward Disease Prevention via Wearable Devices

Detection of Gaseous Compounds with Different Techniques

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