Monolithic capillary columns based on silica and zirconium oxides for use in hydrophilic interaction liquid chromatography

Recent Progress in Monolithic Silica Columns for High-Speed and High-Selectivity Separations

“…Similarly, but at a far lower temperature, zirconia (ZrO 2 ) coating was possible; this showed different selectivity for xanthine derivatives compared with a bare silica monolith column (124). Coating with ZrO 2 did not affect the column efficiency (125). Silver nanoparticles have been introduced by on-column reduction of AgNO 3 by formaldehyde.…”

Matrix-assisted DOSY

“…While the majority of HPLC columns use silica stationary phases, other materials can be used, with zirconia being particularly common [106]. The use of an alternative base support can impart differences in selectivity and hence separation due to differences in pH, surface interactions and polarizability [106,107]. Solid-state 13 C NMR has been used, in conjunction with other characterisation methods and molecular dynamics, to investigate the chain ordering of C30 chains assembled on silica, titania and zirconia surfaces, with greater ordering observed on the group 4 oxides, albeit with large amplitude motions present at the termini of the alkyl chains [108].…”

Preparation, chromatographic evaluation and application of adenosine 5′-monophosphate modified ZrO2/SiO2 stationary phase in hydrophilic interaction chromatography

“…These SPs showed good retention of phenols, benzoic acids, bases and adenosines. Additionally, the bare ZrO 2 monolith [24] and ZrO 2 /SiO 2 composite monolith [25] were attempted in HILIC mode, which had the capacity to differentiate compounds with different spatial configurations. In our recent study [26], the ZrO 2 -based SP was demonstrated as a promising HILIC SP after systematic investigation on the chromatographic performance and retention mechanism of bare ZrO 2 and MgO-ZrO 2 columns.…”