Monomeric CRP Aggravates Myocardial Injury After Myocardial Infarction by Polarizing the Macrophage to Pro-Inflammatory Phenotype Through JNK Signaling Pathway

Zha, Zhimin; Cheng, Yun; Cao, Lu; Qian, Yanxia; Liu, Xinjian; Guo, Yan; Wang, Junhong

doi:10.2147/jir.s316816

Cited by 19 publications

(13 citation statements)

References 38 publications

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“…Serum Hcy is considered a commonly used specific indicator for assessing cardiovascular disease outcomes [ 28 ]. CRP is a more sensitive indicator of human inflammatory response [ 29 ]. The results of this study show that bisoprolol can effectively regulate serum Hcy and CRP levels, further confirming the superiority of bisoprolol in the treatment of myocardial infarction with cardiac insufficiency.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of Bisoprolol in the Treatment of Myocardial Infarction with Cardiac Insufficiency

Wang

2022

Computational and Mathematical Methods in Medicine

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Background. Bisoprolol is commonly used to treat moderate or severe chronic stable heart failure, coronary heart disease, and hypertension. This study is aimed at analyzing the efficacy of bisoprolol in the treatment of myocardial infarction with cardiac insufficiency and its effect on cardiac function, Hcy, and CRP through meta-analysis. Methods. A total of 120 patients with myocardial infarction and cardiac insufficiency from February 2020 to February 2021 were selected and randomly divided into two groups (control and the observation, n = 60 ) according to the random number table method. The control group was given conventional treatment. The observation group was given bisoprolol on the basis of control group. The clinical efficacy, systolic blood pressure, diastolic blood pressure, heart rate, cardiac function indexes, homocysteine (Hcy), and C-reactive protein (CRP) levels were compared between the two groups before and after treatment through data analysis. Adverse reactions were observed during treatment. Results. Compared with the control group, the total effective rate of the observation group was significantly increased ( p < 0.05 ). After treatment, the levels of heart rate, left ventricular end-diastolic volume (LVEDV), and left ventricular end-systolic volume (LVESV) and serum Hcy and CRP levels in the observation group were significantly lower than those in the control group ( p < 0.05 ). Meanwhile, left ventricular ejection fraction (LVEF) level in the observation group after treatment was higher than that of the control group ( p < 0.05 ). Conclusion. Bisoprolol combined with conventional treatment can reduce serum Hcy and CRP levels in patients with myocardial infarction and cardiac insufficiency and improve cardiac function. Moreover, there are no obvious adverse reactions during the treatment.

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Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of Bisoprolol in the Treatment of Myocardial Infarction with Cardiac Insufficiency

Wang

2022

Computational and Mathematical Methods in Medicine

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“…This suggests that exosomes from the uterine cavity in endometriosis could inhibit macrophage M1 polarization by inhibiting the JNK pathway, and this effect can be treated with anisomycin. Zha et al demonstrated that the activation of the JNK signaling pathway enhances macrophage M1 polarization [ 33 ]. Chen et al also found that the inhibition of JNK phosphorylation was linked to decreased M1 macrophages, which was consistent with our results [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Exosomes from the Uterine Cavity Mediate Immune Dysregulation via Inhibiting the JNK Signal Pathway in Endometriosis

et al. 2022

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Endometriosis is a chronic inflammatory disease with an uncertain pathogenesis. Peritoneal immune dysregulation plays an important role in the pathogenesis of endometriosis. Exosomes are messengers of intercellular communication. This study mainly investigated the role of exosomes from the uterine cavity in endometriosis. Exosomes of the uterine aspirate fluid were isolated and cocultured with macrophages for 48 h. Flow cytometry was used to detect macrophage polarization. A Human MAPK Phosphorylation Antibody Array and Western blot were used to detect the phosphorylation of the MAPK pathway. A microRNA sequencing analysis was used to detect differentially expressed miRNAs. Our research found that exosomes of the uterine aspirate fluid from endometriosis could reduce the proportion of CD80+ macrophages. Additionally, it could inhibit the expression of P-JNK in macrophages. However, the JNK activator anisomycin could increase the proportion of CD80+ macrophages. In addition, exosomes of the uterine aspirate fluid from endometriosis could promote the migration and invasion of endometrial stromal cells by acting on macrophages. The expression of miR-210-3p was increased in both exosomes and the eutopic endometrium in patients with endometriosis through miRNA sequencing, which could also reduce the proportion of CD80+ macrophages. In summary, we propose that exosomes from the uterine cavity in patients with endometriosis may affect the phenotype of macrophages by inhibiting the JNK signaling pathway, thus mediating the formation of an immunological microenvironment conducive to the development of endometriosis.

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“…Recently, Melnikov et al ( 13) described significantly increased concentrations of blood circulating mCRP-bound macrophages in patients with coronary artery disease, whilst Zha et al (14), showed increased infiltration of macrophages polarized to the inflammatory M1 phenotype (induced through the JNK signaling pathway activation) in mice following experimental coronary artery occlusion and intra-venous treatment with mCRP; and this was associated with increased myocardial infarct size, scar and fibrosis. These observations also showed the presence of mCRP in human infarcted myocardial tissue surrounding myocytes in post-mortem tissues, identified by IHC using standard manufactured CRP-binding antibodies.…”

Section: Evidence Of the Disease Modifying Behavior Of Mcrpmentioning

confidence: 99%

Monomeric C-Reactive Protein: Current Perspectives for Utilization and Inclusion as a Prognostic Indicator and Therapeutic Target

2022

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Monomeric C-reactive protein (mCRP), once thought to be a figment of the imagination and whose biological activity was ascribed to its sodium azide preservative, has now pronounced itself as a critical molecule playing a direct role in mediating many of the acute and chronic aberrant pathological responses to inflammation. In this focused mini review, we describe the currently attributed pathobiological interactions of mCRP in disease, where its tissue and cellular distribution and deposition have recently been clearly characterized and linked to inflammation and other pathway-associated progression of neurological and cardiovascular complications and deleterious outcomes. and focus upon current opinions as to the diagnostic and prognostic potential of mCRP-plasma circulating protein and define the possible future therapeutics including ongoing research attempting to block CRP dissociation with small molecule inhibitors or prevention of cell surface binding directly using antibodies or modified orphan drug targeting directed towards CRP, inhibiting its cellular interactions and signaling activation. There is no doubt that understanding the full influence of the biological power of mCRP in disease development and outcome will be considered a critical parameter in future stratified treatment.

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Monomeric CRP Aggravates Myocardial Injury After Myocardial Infarction by Polarizing the Macrophage to Pro-Inflammatory Phenotype Through JNK Signaling Pathway

Cited by 19 publications

References 38 publications

The Efficacy and Safety of Bisoprolol in the Treatment of Myocardial Infarction with Cardiac Insufficiency

The Efficacy and Safety of Bisoprolol in the Treatment of Myocardial Infarction with Cardiac Insufficiency

Exosomes from the Uterine Cavity Mediate Immune Dysregulation via Inhibiting the JNK Signal Pathway in Endometriosis

Monomeric C-Reactive Protein: Current Perspectives for Utilization and Inclusion as a Prognostic Indicator and Therapeutic Target

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