2023
DOI: 10.1016/j.heliyon.2023.e19712
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Monomeric glutaraldehyde fixation and amino acid detoxification of decellularized bovine pericardium for production of biocompatible tissue with tissue-guided regenerative potential

Angélique Lewies,
Lezelle Botes,
Johannes Jacobus van den Heever
et al.
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Cited by 6 publications
(4 citation statements)
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“…This process combines the use of osmotic shock, a multi-detergent solution, delipidation with ethanol, and sterilization in an antibiotic and anti-mycotic solution according to a patented method (Patent: 16702008.0-1455, EU, 2017) ( 38 ). Decellularized-fixed (DF) tissue: Bovine pericardium decellularized as in (ii), then fixed with 0.05% monomeric GA (Polysciences, Inc., USA), and detoxified with an amino acid solution containing 0.1 M glycine ( 39 ). …”
Section: Methodsmentioning
confidence: 99%
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“…This process combines the use of osmotic shock, a multi-detergent solution, delipidation with ethanol, and sterilization in an antibiotic and anti-mycotic solution according to a patented method (Patent: 16702008.0-1455, EU, 2017) ( 38 ). Decellularized-fixed (DF) tissue: Bovine pericardium decellularized as in (ii), then fixed with 0.05% monomeric GA (Polysciences, Inc., USA), and detoxified with an amino acid solution containing 0.1 M glycine ( 39 ). …”
Section: Methodsmentioning
confidence: 99%
“…Schematic representation of the study design. (iii) Decellularized-fixed (DF) tissue: Bovine pericardium decellularized as in (ii), then fixed with 0.05% monomeric GA (Polysciences, Inc., USA), and detoxified with an amino acid solution containing 0.1 M glycine (39).…”
Section: Figurementioning
confidence: 99%
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“…Nevertheless, the cytotoxic nature of GA poses potential risks such as post-implantation protein adsorption, oxidative stress, immune system activation, and failure of endothelialization. 15–18 These adverse effects can result in calcification and SVD, compromising the long-term durability of the implant. 19,20 To address the aforementioned issues, it is imperative to develop multifunctional BHVs with properties of anticoagulation, anti-inflammation, and anti-calcification.…”
Section: Introductionmentioning
confidence: 99%