Mononeuritis Multiplex Associated with Sars-Cov2-Covid-19 Infection: Case Report

Enrique, Estévez-Rivera; Javier, Benavides-Hinestroza; Rubiano, Hernando; Andrés, García-Perdomo Herney

doi:10.23937/2378-3001/1410102

Cited by 5 publications

(10 citation statements)

References 12 publications

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“…However, some case reports and studies showed that neuropathy started after the respiratory symptoms started resolving as in our case [4,13,14]. Nonetheless, most of the cases with these symptoms of peripheral neuropathy had prolonged intensive care stay which was not present in our case [4,7].…”

Section: Discussioncontrasting

confidence: 48%

“…Neurological complications are not as rare as previously believed and both central and peripheral nervous system are being affected by COVID-19 either directly or indirectly [6]. Complications involving the peripheral nervous system are mostly olfactory and gustatory in nature [7]. Few reports have surfaced mentioning GBS and other neuromuscular disorders [6].…”

Section: Discussionmentioning

confidence: 98%

“…Here we have discussed a case of a middle-aged man who developed axonal mononeuropathies as a sequela of COVID-19, an exceedingly rare complication seen in this disease. Majority of the case series and studies have shown that symptoms of peripheral neuropathy appeared along with the respiratory symptoms [7,11]. One study has reported that the neurological symptoms preceded the respiratory symptoms [12].…”

Section: Discussionmentioning

confidence: 99%

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Lower limb axonal mononeuropathies as sequelae of COVID-19: a case report and review of literature

Mahmood

Mushtaq

Kanwar

2022

Egypt J Neurol Psychiatry Neurosurg

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Background Neurological symptoms and complications of Coronavirus disease 2019 (COVID-19) were seldom discussed in the literature initially. Neurological symptoms such as headache, dizziness, anosmia, hypogeusia, and neuralgia are, however, now being reported commonly. Mononeuropathies are rare complications of COVID-19, with most cases associated with prolonged intensive care stay. Case presentation A 61-year-old gentleman with prior history of well-controlled diabetes and hypertension was recently treated for COVID-19 pneumonia with supplemental oxygen and positive pressure ventilation. He now presented with left-sided foot weakness two weeks after recovering from the viral illness. On examination he had normal bulk and tone and a power of 4/5 in proximal and distal muscles of bilateral lower limbs except for ankle dorsiflexion on the left which was 2/5. He also had absent ankle and knee reflexes bilaterally with bilateral flexor plantar reflexes. Since the patient had no back pain and the sensory system was normal, the lesion was localized to the peripheral nerves and a Nerve Conduction Studies and Electromyography (NCS/EMG) was done. NCS/EMG showed findings suggestive of axonal mononeuropathies. Relevant workup done to identify the cause of mononeuropathy was negative including infectious and autoimmune workup. Since diabetes was well-controlled and he had no intensive care stay his findings were presumed to be associated with resolving COVID-19 infection. The patient underwent aggressive daily physical therapy and has started to show improvement in symptoms. Conclusions Complications such as mononeuropathies should be kept in mind in patients recovering from COVID-19 infection, since timely diagnosis can improve clinical outcomes in patients.

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Lower limb axonal mononeuropathies as sequelae of COVID-19: a case report and review of literature

Mahmood

Mushtaq

Kanwar

2022

Egypt J Neurol Psychiatry Neurosurg

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“…This still awaits confirmation from independent study, although as the authors point out, MNM is very difficult to recognize in patients with critical illness, when findings of weakness are likely to be attributed to critical illness neuro/myopathy. We are aware of additional isolated cases of MNM that have been reported (109,110). Brachial neuritis is also described in association with SARS-CoV-2, in isolated case reports (3,111,112).…”

Section: Retroviridaementioning

confidence: 96%

Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections

et al. 2022

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In this article we review complications to the peripheral nervous system that occur as a consequence of viral infections, with a special focus on complications of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We discuss neuromuscular complications in three broad categories; the direct consequences of viral infection, autoimmune neuromuscular disorders provoked by viral infections, and chronic neurodegenerative conditions which have been associated with viral infections. We also include discussion of neuromuscular disorders that are treated by immunomodulatory therapies, and how this affects patient susceptibility in the current context of the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 is associated with direct consequences to the peripheral nervous system via presumed direct viral injury (dysgeusia/anosmia, myalgias/rhabdomyolysis, and potentially mononeuritis multiplex) and autoimmunity (Guillain Barré syndrome and variants). It has important implications for people receiving immunomodulatory therapies who may be at greater risk of severe outcomes from COVID-19. Thus far, chronic post-COVID syndromes (a.k.a: long COVID) also include possible involvement of the neuromuscular system. Whether we may observe neuromuscular degenerative conditions in the longer term will be an important question to monitor in future studies.

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“…COVID-19 and COVID-19 vaccinations are also potential etiologies of mononeuritis multiplex, which can affect various nerves. Based on previous reports, post-COVID-19 and vaccination-related neurological impairments involve cranial nerves such as the facial, trigeminal, and vagus nerves [6][7][8]. However, there are few reports of mononeuritis multiplex following COVID-19 vaccination.…”

Section: Introductionmentioning

confidence: 99%

Hypoglossal Nerve Palsy Following COVID-19 Vaccination in a Young Adult Complicated by Various Medicines

Okayasu¹,

Ohta²,

Yamane³

et al. 2022

Cureus

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Mononeuritis multiplex is a rare form of cerebral nerve palsy caused by various factors. Coronavirus disease 2019 (COVID-19) vaccination could be an etiology of mononeuritis multiplex, which can affect various nerves. Post-COVID-19 and vaccination-related neurological impairments involve cranial nerves such as the facial, trigeminal, and vagal nerves. We report our experience with a 34-year-old man who developed hypoglossal nerve palsy following COVID-19 vaccination, complicated by progressive mononeuritis multiplex. Hypoglossal nerve palsy may occur following COVID-19 vaccination. The symptoms vary and may progress without treatment. Physicians should consider the possibility of mononeuritis multiplex after COVID-19 vaccination and provide prompt treatment for acute symptom progression.

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Mononeuritis Multiplex Associated with Sars-Cov2-Covid-19 Infection: Case Report

Cited by 5 publications

References 12 publications

Lower limb axonal mononeuropathies as sequelae of COVID-19: a case report and review of literature

Lower limb axonal mononeuropathies as sequelae of COVID-19: a case report and review of literature

Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections

Hypoglossal Nerve Palsy Following COVID-19 Vaccination in a Young Adult Complicated by Various Medicines

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