Mononuclear copper(II) and binuclear cobalt(II) complexes with halides and tetradentate nitrogen coordinate ligand: Synthesis, structures and bioactivities

Sadhu, Mehul H.; Kumar, Sujit Baran; Saini, Jaswinder K.; Purani, Sejal; Khanna, Tanvi R.

doi:10.1016/j.ica.2017.06.006

Cited by 21 publications

(6 citation statements)

References 55 publications

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“…The spectrum of the copper (II) complex (4) shows one absorption band at 546 nm which may be due to dxz, dyz→dx 2 -y 2 transition. This transition band is indicative of copper (II) atom with distorted square pyramidal geometry as reported in the literature [41].…”

Section: [Insert Scheme 1]supporting

confidence: 80%

Metal transition complexes of tridentate Schiff base ligands derived from 2-hydrazinopyridine: synthesis, spectroscopic characterization and X-ray structures

et al. 2019

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Mononuclear complexes of 1-(pyridin-2-ylmethylidene)-2-(pyridin-2-yl)hydrazine (HL 1 ) and 1-(pyridin-2-yl)-2-(1-, [Zn(HL 1 )(CH3COO)2] . (H2O)3 (2), [Mn(HL 2 )2] . (ClO4)2 (3) and [Cu(HL 2 )(NO3)2] (4), were synthesized and characterized by physico-chemical and spectroscopic methods and X-ray structure determination. The mononuclear compounds 1, 2 and 4 contain one ligand molecule per metal atom while the manganese (II) atom in the compound 3 is coordinated to two ligand molecules. Both ligands coordinated to the transition metal center in tridentate fashion through two Npyridyl atoms and one Nimino atom. The chloride and acetate anions coordinate in monodentate manner respectively in complex 1 and in complex 2. In complex

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Section: [Insert Scheme 1]supporting

confidence: 80%

Metal transition complexes of tridentate Schiff base ligands derived from 2-hydrazinopyridine: synthesis, spectroscopic characterization and X-ray structures

et al. 2019

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“…The in vitro tests showed that cobalt(III) complexes (43, Figure 9) were more active against Gram-positive bacteria (e.g., S. aureus) and fungal strains (C. albicans) with MIC values of 0.7-3 and 7-250 µg/mL, respectively, and less active against Gram-negative strains, such as E. coli and K. pneumoniae. Several other types of cobalt metal complexes have been tested for their antimicrobial efficacy, however, their activities were not found remarkably high [111][112][113][114][115][116][117][118][119][120][121].…”

Section: Ruthenium Complexesmentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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Antimicrobial resistance is an increasingly serious threat to global public health that requires innovative solutions to counteract new resistance mechanisms emerging and spreading globally in infectious pathogens. Classic organic antibiotics are rapidly exhausting the structural variations available for an effective antimicrobial drug and new compounds emerging from the industrial pharmaceutical pipeline will likely have a short-term and limited impact before the pathogens can adapt. Inorganic and organometallic complexes offer the opportunity to discover and develop new active antimicrobial agents by exploiting their wide range of three-dimensional geometries and virtually infinite design possibilities that can affect their substitution kinetics, charge, lipophilicity, biological targets and modes of action. This review describes recent studies on the antimicrobial activity of transition metal complexes of groups 6–12. It focuses on the effectiveness of the metal complexes in relation to the rich structural chemical variations of the same. The aim is to provide a short vade mecum for the readers interested in the subject that can complement other reviews.

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“…There are three five member chelate rings with metal ion and their chelate bite angles are N(1)–Cu(1)–N(3) [80.98(6)], N(3)–Cu(1)–N(5) [81.46(6)] and N(3)–Cu(1)–S(1) [83.64(4)] [34, 35]. The shortest Cu….Cu and Cu(1)….Cl(1) [‐x, 1‐y, 1‐z] distances are 3.729 and 3.020 Å respectively, thus formation of supramolecular dimer is observed [Figure (b)] and similar type supramolecular dimers are reported in the literature ,…”

Section: Resultsmentioning

confidence: 99%

“…Ligand with ‘soft’ S donors e. g. thio‐ether, thiolates etc are considered as bio‐ligand and S‐containing chelating ligands have useful applications . Recently we have synthesized, structurally characterized and studied bioactivities of copper(II) and cobalt(II) complexes with tetradentate heterocyclic N 4 ‐coordinate pyrazolyl based ligand in presence of halide or pseudohalides as co‐ligands . Now we would like to extend our approach with copper(II) complexes with S,N‐containing another tetradentate pyrazolyl based N 3 S‐donor ligand in presence of halide ions.…”

Section: Introductionmentioning

confidence: 99%

Mononuclear Copper(II) Halide Complexes with Tetradentate N₃S‐Coordinate Ligands: Synthesis, Structures and Bioactivities

et al. 2018

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A series of mononuclear copper(II) complexes [Cu(bdmpe/bpmpe)X]Y [bdmpe= N,N‐bis((3,5‐dimethyl‐1H‐pyrazol‐1‐yl)methyl)‐2‐(phenylthio)ethan‐1‐amine, Y=PF6−, X=Cl 1, Br 3 and Y=BF4−, X=Cl 2, Br 4; bpmpe=N,N‐bis((1H‐pyrazol‐1‐yl)methyl)‐2‐(phenylthio)ethan‐1‐amine; Y=PF6−, X=Cl 5, Br 7 and Y=BF4−, X=Cl 6, Br 8] have been synthesized by the reaction of copper halides with ligands bdmpe/bpmpe in presence of Y and characterized. Single crystal X‐ray crystallography study indicates that complexes are mononuclear with distorted square pyramidal geometry. Complexes 1 and 7 show supramolecular dimeric nature due to short intermolecular interactions. The antimicrobial activity of all complexes were investigated against Gram positive (Bacillus subtilis, Streptococcus aureus) and Gram negative (Escherichia coli, Pseudomonas aeruginosa) bacterial strain by agar well dilution method and have demonstrated significant antimicrobial activity of the compounds. The studies on the interaction of complexes and DNA by agarose gel electrophoresis method revealed that the complexes can effectively cleave the circular plasmid DNA at very low concentrations.

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Mononuclear copper(II) and binuclear cobalt(II) complexes with halides and tetradentate nitrogen coordinate ligand: Synthesis, structures and bioactivities

Cited by 21 publications

References 55 publications

Metal transition complexes of tridentate Schiff base ligands derived from 2-hydrazinopyridine: synthesis, spectroscopic characterization and X-ray structures

Metal transition complexes of tridentate Schiff base ligands derived from 2-hydrazinopyridine: synthesis, spectroscopic characterization and X-ray structures

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Mononuclear Copper(II) Halide Complexes with Tetradentate N₃S‐Coordinate Ligands: Synthesis, Structures and Bioactivities

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Mononuclear copper(II) and binuclear cobalt(II) complexes with halides and tetradentate nitrogen coordinate ligand: Synthesis, structures and bioactivities

Cited by 21 publications

References 55 publications

Metal transition complexes of tridentate Schiff base ligands derived from 2-hydrazinopyridine: synthesis, spectroscopic characterization and X-ray structures

Metal transition complexes of tridentate Schiff base ligands derived from 2-hydrazinopyridine: synthesis, spectroscopic characterization and X-ray structures

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Mononuclear Copper(II) Halide Complexes with Tetradentate N3S‐Coordinate Ligands: Synthesis, Structures and Bioactivities

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Mononuclear Copper(II) Halide Complexes with Tetradentate N₃S‐Coordinate Ligands: Synthesis, Structures and Bioactivities