Monosodium glutamate, a food additive, induces depressive-like and anxiogenic-like behaviors in young Rats

Quines, Caroline Brandão; Rosa, Suzan Gonçalves; Rocha, Juliana Trevisan da; Gai, Bibiana Mozzaquatro; Bortolatto, Cristiani F.; Duarte, Marta Maria Medeiros Frescura; Nogueira, Cristina W.

doi:10.1016/j.lfs.2014.04.032

Cited by 75 publications

(52 citation statements)

References 35 publications

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“…In agreement with that, L-glutamic acid was reported to decrease serotonin synthesis, release in rat rostral and caudal rhombencephalic raphe cells culture and cause an increase in serotonin metabolism (Becquet et al, 1993). In another study; subcutaneous injection of MSG in newborn rats (4 g/kg/day from the 1st to 5th postnatal day) results in an increase in the serotonin uptake in cerebral cortices (Quines et al, 2014).…”

Section: Discussionmentioning

confidence: 89%

“…It has been reported that MSG has neurotoxic effects resulting in brain cell damage, retinal degeneration, endocrine disorders and some pathological conditions such as, stroke, epilepsy, neuropathic pain, schizophrenia, anxiety, depression, Parkinson s disease, Alzheimer's disease, Huntington's chorea, and amyotrophic lateral sclerosis, cited in (Eweka et al, 2013). Also, MSG can cause anxiogenic-and depressive-like behaviors (Porsolt et al, 1979;Onishi & Xavier, 2010;Quines et al, 2014). Some studies reveled that it can affect the cognitive function and learning ability (AbuTaweel et al, 2014),memory retrieval (Pilgrim et al, 2012;Summers et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Monosodium glutamate affects cognitive functions in male albino rats

Moneim

Yassa

Makboul

et al. 2018

Egypt J Forensic Sci

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Monosodium glutamate affects cognitive functions in male albino rats

Moneim

Yassa

Makboul

et al. 2018

Egypt J Forensic Sci

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“…Meanwhile experiments to reveal its possible effects on animals are still being conducted. Artificial flavor enhancers such as MSG may cause animals to display behaviors similar to anxiety, epilepsy, and depression (17)(18)(19)(20)(21). Behaviors similar to anxiety can be identified by the means of experimental open field test, light/dark transition test, elevated plus maze test, tail suspension test, forced swim test, and social interaction task (22).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the behavioral and neurochemical effects of monosodium glutamate on neonatal rats

Kardeşler

Başkale

2017

Turk J Med Sci

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Background/aim: The objective of this study was to investigate and analyze the behavioral and neurochemical effects of monosodium glutamate (MSG) injections at various and subsequent dosages on male Wistar rats during the neonatal period. Materials and methods:In order to determine the behavioral and neurochemical effects of MSG, the experiment was implemented on neonatal male Wistar rats and the test was repeated for various MSG dosages. After completing the experiment, additionally, levels of dopamine, GABA, catecholamine (dopamine, noradrenaline, and adrenaline) and glutamate in the brain cells of the decapitated rats were also measured using the ELISA method.Results: Considering the results of the behavioral test, when we compared the test values of the control group with the values of the MSG-injected groups we noted that there were significant differences in the statistical figures obtained. Additionally, we found that the statistical figures of some neurochemical parameters were also significantly different when we compared the values of the MSG group with the control values. Conclusion:MSG injection has a clear effect on the neurochemical parameters, learning memory, and locomotor activities of rats.

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“…Monosodium L-glutamate treated rats have also been reported to be more susceptible to develop anxiogenic and depressive like behaviour (Quines et al, 2014). Oral consumption Monosodium L-glutamate appears to cause alkaline urine and may increase the risks of kidney stones with hydronephrosis in rats (Sharma et al, 2013).…”

Section: Potentially Harmful Artificial and Natural Colours Found In mentioning

confidence: 99%

Proliferation of Illegal and Potentially Hazardous Food Additives in Processed and Packaged Foods in Africa: A Case Study and Hazard Identification in Ghana

Setsoafia¹

2015

J. of Food Resource Science

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In the developed countries, a lot of researches have been carried out on the effects of food additives on consumers but few studies have been reported in Africa and particularly Ghana. The objective of the study was to survey labels of processed and packaged foods in Ghana and document all the potentially harmful food additives in processed and packaged foods in some Ghanaian food products. We purchased 63 processed and packaged food products from the Ghanaian market and documented food additives on their labels as well as trade name, type of food, company name, country of origin and whether the Ghana Food and Drugs Authority (GFDA) certified them. Thirty seven percent of all the products sampled on the market were not registered with the GFDA. Seventy one percent of all the products sampled contained one or more additives that are likely to cause adverse reactions when consumed. The general public is at risk of consuming potentially hazardous food additives. There is the need for a research to determine whether the levels of additives are above the recommended acceptable daily intake proposed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA).

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Monosodium glutamate, a food additive, induces depressive-like and anxiogenic-like behaviors in young Rats

Cited by 75 publications

References 35 publications

Monosodium glutamate affects cognitive functions in male albino rats

Monosodium glutamate affects cognitive functions in male albino rats

Investigation of the behavioral and neurochemical effects of monosodium glutamate on neonatal rats

Proliferation of Illegal and Potentially Hazardous Food Additives in Processed and Packaged Foods in Africa: A Case Study and Hazard Identification in Ghana

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