Monosodium glutamate-induced changes on plasma markers of pancreatic function in adult male Wistar rats

Abd-Ul-Salam, Hani A.H.; Adamu, Sadeeq Abubaka; Sambo, S.J.; Chiroma, Mbursa; Gadzama, J.J.; Mohzo, D.L.; Atata, J.A.

doi:10.4314/sokjvs.v16i2.3

Cited by 7 publications

(8 citation statements)

References 6 publications

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“…The current results were in agreement withSeiva et al (2012);Abdulsalam et al (2018) andMoen et al (2020) who reported significant elevation in the levels of lipase and amylase enzymes in the MSG-treated group compared to the control group.Contrary to the present study,Yadav et al. (2010) showed that MSG induced a dosedependent inhibitory effect on gastrointestinal alpha-amylase enzyme activity.…”

supporting

confidence: 93%

“…On contrary, Abdulsalam et al (2018) revealed that no histopathological changes in β-islets cells of Langerhans and only congestion of blood vessels of the pancreas in both MSG-treated and non-MSG-control rats were observed.…”

Section: Regardingmentioning

confidence: 74%

“…By studying the toxic effect of MSG on pancreatic enzymes, the present study revealed a significant rise in the serum level of amylase and lipase enzymes in MSG treated group which could be attributed to their release into the blood circulation instead of passing through the duct to the intestine. This might result from the primary effect of oxidative injury of MSG or impaired membrane permeability of the acinar cells (Azevedo-Martins et al, 2003 andAbdulsalam et al, 2018). author used the following concentrations of MSG; 2%, 6%, 8%, and 10%, there was inhibition in the enzyme activity levels; 1750, 1500, 1400, and 600 units respectively compared to the control value of 2800 units.…”

Section: Discussionmentioning

confidence: 99%

“…The pancreas is one of the organs which may be affected by many toxins. However, few reports that studied the effect of MSG on the pancreas which resulted in a scarcity of information on exocrine functions (Kumar et al, 2015 andAbdulsalam et al, 2018).…”

Section: Introduction mentioning

confidence: 99%

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Ameliorative role of tannic acid on monosodium glutamate-induced pancreatic toxicity on albino rats

Mohamed

Radwan

Mohamed

et al. 2021

Mansoura Journal of Forensic Medicine and Clinical Toxicology

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Monosodium Glutamate (MSG) is a widely used food additive that has several deleterious effects on different body organs. Tannic acid (TA) is a naturally occurring antioxidants with several pharmacological properties. The present study was designed to study the toxic effects of MSG on the pancreas with the possible ameliorative role of TA. Forty male albino rats were used in this study in the form of four groups, 10 rats each. Group I, was the control group, fed on the standard diet, Group II received TA (100mg/kg), Group III received MSG (2g/kg) and Group IV received TA and MSG orally by gavage for 4weeks. Biochemical analysis revealed that MSG affected the pancreatic function by a significant increase in the serum levels of amylase and lipase enzymes, as well as, the blood sugar level (p < 0.001) meanwhile it did not significantly affect plasma insulin level (p>0.05). Histopathological examination showed severe destruction in the pancreatic architecture with hypertrophy and hyperplasia in the pancreatic islets as well as a decrease in the number of acinar cells in addition to congestion and dilation in the blood vessels. Co-administration of TA with MSG attenuated these effects; this role may be explained by its anti-oxidative effects that need future research to explain the mechanism of action. It is concluded that MSG has a deleterious effect on the pancreas functionally and morphologically and TA act as a good antioxidant agent against MSG toxicity.

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supporting

confidence: 93%

Section: Regardingmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introduction mentioning

confidence: 99%

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Ameliorative role of tannic acid on monosodium glutamate-induced pancreatic toxicity on albino rats

Mohamed

Radwan

Mohamed

et al. 2021

Mansoura Journal of Forensic Medicine and Clinical Toxicology

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“…This is in agreement with the findings reported in similar studies. Abdulsalam et al (2018) also observed no changes in insulin levels or glucose tolerance during MSG supplementation. They argue that the functional blood glucose impairment may require a second hit or a separate factor for susceptibility.…”

Section: Discussionmentioning

confidence: 73%

effects of Orally Administered Monosodium Glutamate (MSG) on the Metabolic Syndrome of Adult Albino Rats

Utume

Ansha

Gav

2020

Nig Ann pure App Sci

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Monosodium Glutamate (MSG) or glutamate is a commonly used flavour enhancer, naturally found in protein-rich foods; although produced commercially through the fermentation of molasses. MSG is essential in the metabolism of living bodies. The increase in MSG consumption has become a growing concern due to the lack of adequate data on its effects. This study investigates the effects of MSG on weight and blood glucose levels of adult albino rats for an experimental period of eight (8) weeks. Twenty-four (24) albino rats weighing between 48.7 g to 94.6 g were randomly divided into four (4) groups of six (6) rats each: 1 control group and 3 test groups. Test groups were fed and daily doses of MSG dissolved in water (8 g/L, 10 g/L and 15 g/L respectively) were administered orally. The control group were fed on plain water and rat chow (grower’s mash) only. Weekly weights, fasting blood glucose levels of rats were measured, and change in behaviour and exploratory tendencies observed, all through the experimental period. Glycosylated haemoglobin was tested at the end of the experimental period to confirm the weekly blood glucose levels. There was no significant difference in the average weights (P ˃ 0.05). Blood glucose levels maintained a normal range of 4.5 – 5.1 % (good glycemic control) over the experimental period. The study illustrates that Monosodium Glutamate has no adverse effects on weight and blood glucose levels when consumed daily, but not exceeding a 15 g dose. Further research to validate casual inference may be necessary. The consumption of MSG should be in moderation and individuals prone to hypoallergenic reactions should ensure to check product labels for MSG before the consumption of foods. Further research can be carried out using higher doses as well as other metabolic markers in the body to further consolidate empirical data.

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Response to “the Letter to the Editor by Yoshida et al., Monosodium glutamate added to food does not induce damage to the pancreas nor aggravate diabetes due to enhancement of oxidative stress” for editorial evaluation

Urcar Gelen

2024

J Biochem & Molecular Tox

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Monosodium glutamate-induced changes on plasma markers of pancreatic function in adult male Wistar rats

Cited by 7 publications

References 6 publications

Ameliorative role of tannic acid on monosodium glutamate-induced pancreatic toxicity on albino rats

Ameliorative role of tannic acid on monosodium glutamate-induced pancreatic toxicity on albino rats

effects of Orally Administered Monosodium Glutamate (MSG) on the Metabolic Syndrome of Adult Albino Rats

Response to “the Letter to the Editor by Yoshida et al., Monosodium glutamate added to food does not induce damage to the pancreas nor aggravate diabetes due to enhancement of oxidative stress” for editorial evaluation

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