Monosodium glutamate induced testicular lesions in rats (histological study)

Alalwani, Aisha D.

doi:10.1016/j.mefs.2013.09.003

Cited by 61 publications

(37 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rats in group III (low dose) showed a significant increase in body weight compared to control group (p < 0.05). This is concordant with Alalwani, 2014(Alalwani, 2014 who reported a significant weight gain in MSG treated rats (single daily dose 30 or 60 mg/kg intra-peritoneal injection for 2 months). Another supporting study reported that MSG treated rats (subcutaneous injection of 4 g MSG/ kg body weight /day] presented higher body weights than the control rats, despite the fact that treated rats were found to be hypophagic, presenting lower average daily food consumption (de Oliveira Lazarin et al, 2011).…”

Section: Discussionsupporting

confidence: 90%

“…The different effect of MSG on body weight might be due to the variations in dose regimen and perhaps to different periods or duration of exposure and the type or strain of the animals used in these studies. Although MSG could improve the palatability of foods by exerting a positive influence on the appetite center (Alalwani, 2014). Its main effect on body weight is by increasing mRNA expression of interleukin-6, tumor necrosis factor-alpha, resistin and leptin in visceral adipose tissue, it increased insulin, resistin and leptin levels in serum and it also impaired glucose tolerance.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Monosodium glutamate affects cognitive functions in male albino rats

Moneim

Yassa

Makboul

et al. 2018

Egypt J Forensic Sci

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Monosodium glutamate affects cognitive functions in male albino rats

Moneim

Yassa

Makboul

et al. 2018

Egypt J Forensic Sci

View full text Add to dashboard Cite

show abstract

“…Although there has been a controversy on the safety of MSG for decades, however, several studies have indicated the toxicity of MSG. Indeed, it has been implicated in genotoxicity, Chinese restaurant syndrome, asthma, neurological effects, reproductive organs dysfunction, and renal toxicity in rodents.…”

Section: Introductionmentioning

confidence: 99%

Dietary consumption of monosodium L‐glutamate induces adaptive response and reduction in the life span of Drosophila melanogaster

Abolaji

Olaiya

Oluwadahunsi

et al. 2017

Cell Biochemistry & Function

View full text Add to dashboard Cite

Adaptive response is the ability of an organism to better counterattack stress-induced damage in response to a number of different cytotoxic agents. Monosodium L-glutamate (MSG), the sodium salt of amino acid glutamate, is commonly used as a food additive. We investigated the effects of MSG on the life span and antioxidant response in Drosophila melanogaster (D. melanogaster). Both genders (1 to 3 days old) of flies were fed with diet containing MSG (0.1, 0.5, and 2.5-g/kg diet) for 5 days to assess selected antioxidant and oxidative stress markers, while flies for longevity were fed for lifetime. Thereafter, the longevity assay, hydrogen peroxide (H O ), and reactive oxygen and nitrogen species levels were determined. Also, catalase, glutathione S-transferase and acetylcholinesterase activities, and total thiol content were evaluated in the flies. We found that MSG reduced the life span of the flies by up to 23% after continuous exposure. Also, MSG increased reactive oxygen and nitrogen species and H O generations and total thiol content as well as the activities of catalase and glutathione S-transferase in D. melanogaster (P < .05). In conclusion, consumption of MSG for 5 days by D. melanogaster induced adaptive response, but long-term exposure reduced life span of flies. This study may therefore have public health significance in humans, and thus, moderate consumption of MSG is advocated by the authors.

show abstract

“…Female, twelve weeks old,Wistar rats ingested with of MSG at dose 140mg/200 gram body weight (bw) with or without combination of vitamin C and E. MSG dose in seven until ten fold higher than previous studies 16,17 .The duration of MSG treatment is subchronic (42 days) 18 . Twenty five rats were divided into five group (n = 5 each), …”

Section: Animalmentioning

confidence: 99%

Vitamin C-E ve Monosodyum Glutamata Bağlı Ovaryan Toksisite

Rohmawati¹,

Istiananingsih²,

Nurdiana³

et al. 2014

Cukurova Medical Journal

View full text Add to dashboard Cite

Purpose: Our study aimed to investigate the combinatorial effect of vitamin C and E on oxidative stress, the number of folicles, and hormonal level in female rats orally exposed to monosodium glutamate (MSG). Materials and Methods:Female, twelve weeks old Wistar rats ingested with of MSG at dose 140 mg/200 gram body weight (bw) with or without combination of vitamin C and E. Twenty five rats were divided into five group (n = 5 each), control group, MSG-treatment group, MSG-treatment + 0.2 mg/g bw vitamin C + 0.04 IU/g bw vitamin E (MSG + CE1), MSG-treatment + 0.4 mg/g bw vitamin C + 0.04 IU/g bw vitamin E (MSG + CE2), and MSG-treatment + 0.6 mg/g bw vitamin C + 0.04 IU/g bw vitamin E (MSG + CE1). Analysis of malondialdehyde (MDA) level was done colorimetrically. Analysis of the number of ovarian follicles was done histopathologically with hematoxylin eosin staining. Analysis of 17β-estradiol and follicle stimulating hormone (FSH) levels were done by ELISA technique. Results: There were significantly (P < 0.05) increased ovarium MDA levels and atresia follicle number in groups exposed to MSG compared to non-exposure group. The level of FSH, 17β-estradiol, the number of primary, secondary, de Graaf follicles were significantly lower in MSG-treatment group compared to control group (P < 0.05). The administration of combined vitamin C and E (second and third dose) significantly (P < 0.05) decreased the MDA levels and the number of atresia follicle compared to the MSG-exposed groups, to reach level in control group (P > 0.05). MSG + CE2 and MSG + CE3 significantly increased FSH level, number of primary follicles, compared to MSG-treatment group (P < 0.05), to reach similar level in control group (P > 0.05). All dose of combined vitamin C and E significantly increased 17β-estradiol level and the number of secondary and de Graaf follicles compared to MSG-treatment group (P < 0.05), to reach significantly higher level compared to control group (P < 0.05). Conclusion:The present data suggest that combination of vitamin C and E as in this study inhibited ovarium toxicity caused by MSG treatment. Keywords: glutamate; antioxidant; folliculogenesis; hormone; lipid peroxidation Sadece MSG verilmiş grup ile karşılaştırıldıklarında; C ve E vitaminlerinin tüm dozlarının, 17β-estradiol düzeyi ile sekonder ve graff folikül sayılarını anlamlı olarak arttırdıkları tespit edilmiştir (P < 0.05). C ve E vitaminlerinin verildiği gruplarda, 17β-estradiol düzeyi ile sekonder ve graffolikül sayıları, kontrol grubunun üzerindeki düzeylere ulaşmıştır (P < 0.05).Sonuç: Bulgularımız C ve E vitamin kombinesinin MSG'ya maruz kalmaya bağlı olarak gelişen ovaryum toksisitesini inhibe ettiği sonucunu ortaya koymuştur.

show abstract

Monosodium glutamate induced testicular lesions in rats (histological study)

Cited by 61 publications

References 25 publications

Monosodium glutamate affects cognitive functions in male albino rats

Monosodium glutamate affects cognitive functions in male albino rats

Dietary consumption of monosodium L‐glutamate induces adaptive response and reduction in the life span of Drosophila melanogaster

Vitamin C-E ve Monosodyum Glutamata Bağlı Ovaryan Toksisite

Contact Info

Product

Resources

About