Monosodium glutamate influences depressive behavior of two age groups of mice in forced swimming test: Vitamin B6 could remedy the situation

Mesripour, Azadeh; Kadivar, Masoud; Hajhashemi, Valiollah

doi:10.1016/j.pmip.2019.05.002

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…Studies investigating the effects of subchronic and chronic exposure to oral MSG on anxiety in both infant and adult mice using the elevated plus maze demonstrated anxiolytic-like behavior in some and anxiety-like behavior in others (39,(41)(42)(43). In the forced swimming tests, in which the effects of oral MSG on anxiety were investigated, the results were found to be contradictory, it was seen that it both increased and suppressed anxiety (37,44). In a study examining the effects of oral intermittent MSG on total motor activity, it did not differ from controls (10).…”

Section: Discussionmentioning

confidence: 99%

Kronik Monosodyum Glutamat Tüketiminin Yavru Sıçanlarda Naloksonla Tetiklenen Morfin Yoksunluğu Üzerine Etkileri

Demirkapu

Özen

Ozkula

et al. 2022

Batı Karadeniz Tıp Dergisi

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Aim: The aim of this study was to investigate chronic oral monosodium glutamate (MSG) consumption effects on symptoms of withdrawal, locomotor activity, and anxiety in morphine withdrawal syndrome induced by naloxone in infant rats. Materials and Methods: Twelve 21-day-old male Wistar rats used in the study. Infant rats were given unlimited access to saline (control group) or MSG (MSG group) added to drinking water for 32 days. Withdrawal was induced by naloxone in morphine-dependent rats. Evaluation of withdrawal symptoms and anxiety were performed simultaneously with locomotor activity measurements. Results: Withdrawal sings, such as jumping, wet dog shake, and weight loss; stereotypic, ambulatory, and vertical locomotor activity movements; central, peripheral, and total activities used in the assessment of anxiety in infant rats with naloxone-induced withdrawal syndrome that consumed oral MSG for 32 days were not different from the control group. Conclusion: These findings obtained in our study indicate that chronic consumption of oral MSG in infant rats whose blood-brain barrier has not yet developed does not affect morphine dependence and naloxone-induced withdrawal. Further studies are needed to investigate the mechanism of action of orally administered MSG.

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Section: Discussionmentioning

confidence: 99%

Kronik Monosodyum Glutamat Tüketiminin Yavru Sıçanlarda Naloksonla Tetiklenen Morfin Yoksunluğu Üzerine Etkileri

Demirkapu

Özen

Ozkula

et al. 2022

Batı Karadeniz Tıp Dergisi

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“…However, intake of these essential proteins has shown a reversal of depressive symptoms ( Sato et al, 2020 ). Administration or consumption of glutamate is reported to exacerbate depression symptoms, possible because it causes excessive glutamate release, which is toxic to the brain and linked to many neurodegenerative diseases, and associated with exposure to chronic stress, and excessive glutamate release and uptake ( Reiner and Levitz, 2018 , Mesripoura et al, 2019 , Kraal et al, 2020 ).…”

Section: Application Of Nutrition In Depression Managementmentioning

confidence: 99%

Nutritional therapy can reduce the burden of depression management in low income countries: A review

Ekong

Iniodu

2021

IBRO Neuroscience Reports

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Depression is a serious mental and mood disorder with global health and economic burden. This burden may be overwhelming in low income countries, although there are insufficient data. Most antidepressant formulations are predicated on the monoamine, neuroendocrine and neuro-inflammation hypotheses, with little or no cognizance to other neurochemicals altered in depression. A nutritional strategy with or without conventional antidepressants is recommended, as nutrition plays vital roles in the onset, severity and duration of depression, with poor nutrition contributing to its pathogenesis. This review discusses nutritional potentials of utilizing omega-3 fatty acids, proteins, vitamins, minerals and herbs or their phytochemicals in the management of depression with the aim of reducing depression burden. Literature search of empirical data in books and journals in data bases including but not limited to PubMed, Scopus, Science Direct, Web of Science and Google Scholar that might contain discussions of sampling were sought, their full text obtained, and searched for relevant content to determine eligibility. Omega-3 fatty and amino acids had significant positive anti-depression outcomes, while vitamins and minerals although essential, enhanced omega-3 fatty and amino acids activities. Some herbs either as whole extracts or their phytochemicals/metabolites had significant positive anti-depression efficacy. Nutrition through the application of necessary food classes or herbs as well as their phytochemicals, may go a long way to effectively manage depression. This therefore will provide inexpensive, natural, and non-invasive therapeutic means with reduced adverse effects that can also be applied alongside clinical management. This nutritional strategy should be given more attention in research, assessment and treatment for those with depression and other mental illness in low income countries, especially in Africa.

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“…Although MSG is generally considered safe, there have been reports of neurotoxic properties dating back to the early years of MSG consumption (Burde et al, 1971). Previous reports have indicated that MSG is anxiogenic (Onaolapo et al, 2012), induces depression (Mesripour et al, 2019), reduces explorative activity (Seo et al, 2010), is proconvulsive (López‐Pérez et al, 2010) and impairs memory and learning (López‐Vázquez et al, 2019) in young or adult rodents. However, the effect of exposure to MSG in utero on the neurodevelopment and behaviour of the offspring of exposed dams is yet unstudied.…”

Section: Introductionmentioning

confidence: 99%

Effects of in utero exposure to monosodium glutamate on locomotion, anxiety, depression, memory and KCC2 expression in offspring

Biney

Djankpa

Osei

et al. 2021

Intl J of Devlp Neuroscience

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In pregnancy, there is a significant risk for developing embryos to be adversely affected by everyday chemicals such as food additives and environmental toxins. In recent times, several studies have documented the detrimental effect of exposure to such chemicals on the behaviour and neurodevelopment of the offspring. This study evaluated the influence of the food additive, monosodium glutamate (MSG), on behaviour and development in mice. Pregnant dams were exposed to MSG 2 or 4 g/kg or distilled water from gestation day 10–20. On delivery, postnatal day 1 (PN 1), 3 pups were sacrificed and whole brain samples assayed for KCC2 expression by western blot. The remaining pups were housed until PN 43 before commencing behavioural assessment. Their weights were measured at birth and at 3 days intervals until PN 42. The impact of prenatal exposure to MSG on baseline exploratory, anxiety and depression behaviours as well as spatial and working memory was assessed. In utero exposure to 4 g/kg MSG significantly reduced exploratory drive and increased depression‐like behaviours but did not exert any significant impact on anxiety‐like behaviours (p < 0.01). Additionally, there was a two‐fold increase in KCC2 expression in both 2 and 4 g/kg MSG‐exposed offspring. Conclusion This study indicates that, in utero exposure to MSG increases the expression of KCC2 and causes significant effect on locomotion and depression‐like behaviours but only marginally affects memory function.

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Monosodium glutamate influences depressive behavior of two age groups of mice in forced swimming test: Vitamin B6 could remedy the situation

Cited by 3 publications

References 32 publications

Kronik Monosodyum Glutamat Tüketiminin Yavru Sıçanlarda Naloksonla Tetiklenen Morfin Yoksunluğu Üzerine Etkileri

Kronik Monosodyum Glutamat Tüketiminin Yavru Sıçanlarda Naloksonla Tetiklenen Morfin Yoksunluğu Üzerine Etkileri

Nutritional therapy can reduce the burden of depression management in low income countries: A review

Effects of in utero exposure to monosodium glutamate on locomotion, anxiety, depression, memory and KCC2 expression in offspring

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