Monosomy X as a recurring sole cytogenetic abnormality associated with myelodysplastic diseases

Abruzzese, Elisabetta; Rao, P. Nagesh; Slatkoff, M. L.; Cruz, Julia M.; Powell, Bayard L.; Jackle, Bethy; Pettenati, Mark J.

doi:10.1016/s0165-4608(97)83556-x

Cited by 20 publications

(8 citation statements)

References 32 publications

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“…These findings suggest that when -X presents as a major clone in BM, it is often disease associated. Similar findings have been reported by Abruzzese et al [7], in their study 5 patients with MDS showed -X as a major clone in the BM (80%-100% by conventional cytogenetic analysis and 32% to 94.5% by interphase FISH analysis).…”

Section: Discussionsupporting

confidence: 91%

“…However, the clinical impact of -X as a sole chromosomal abnormality in BM has been assessed rarely. So far, only a few cases with isolated -X in BM have been reported in patients who had acute lymphoblastic leukemia (ALL) [6], myelodysplastic syndromes (MDS) [7], acute myeloid leukemia (AML) [8] and chronic lymphocytic leukemia [9]. Due to its rarity, the clinical importance of isolated -X in BM is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of acquired loss of the X chromosome in bone marrow

Tang

Wang

et al. 2016

Leukemia Research

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Clinical significance of acquired loss of the X chromosome in bone marrow

Tang

Wang

et al. 2016

Leukemia Research

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“…the sole cytogenetic abnormality has been predominantly reported for myelodysplastic disorders [Abruzzese et al, 1997]. However, the loss of one X chromosome as the only aberration is also found in acute lymphoblastic leukemia [Bueno et al, 1999].…”

Section: Resultsmentioning

confidence: 99%

Cytogenetic Analysis of CpG-Oligonucleotide DSP30 plus Interleukin-2-Stimulated Canine B-Cell Lymphoma Cells Reveals the Loss of One X Chromosome as the Sole Abnormality

Reimann-Berg

Escobar

Kiefer

et al. 2011

Cytogenet Genome Res

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Human and canine lymphoid neoplasms are characterized by non-random cytogenetic abnormalities. However, due to the low mitotic activity of the B cells, cytogenetic analyses of B-cell lymphoid proliferations are difficult to perform. In the present study we stimulated canine B-cell lymphoma cells with the immunostimulatory CpG-oligonucleotide DSP30 in combination with interleukin-2 (IL-2) and obtained an adequate number of metaphases. Cytogenetic analyses revealed the loss of one X chromosome as the sole cytogenetic aberration. Chromosome analysis of the corresponding blood showed a normal female karyotype. Monosomy X as the sole clonal chromosomal abnormality is found in human hematopoietic malignancies as well, thus the dog may serve as a promising animal model.

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“…X-monosomy has been reported in myelodysplastic syndrome and several cancers (41,42) and in peripheral blood leukocytes of patients with autoimmune disorders (43,44), although there the inactive X was lost. Indeed, it was assumed that loss of the active X would be cell lethal (44).…”

Section: Discussionmentioning

confidence: 99%