Monoterpenoid indole alkaloids from the fruits of Melodinus henryi

Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents

“…Besides, some quinoline and indole alkaloids isolated from Melodinus plants, such as 15-dihydroscandine, 15β-hydroxy-14,15-dihydroscandine, melaxillines A and B, melodinine T, scandine, 11-hydroxytabersonine, and O-methyl-Δ 14 -vincanol-3-one exhibited significant anti-inflammatory activity [17,28,44,45]. Among the isolates in this study, tabersonine (4) could attenuate LPSinduced acute lung injury and inhibited LPS-mediated macrophage activation in vitro [46], 11-hydroxytabersonine (5) showed inhibitory effect on NO production [17], tubotaiwine (9) showed good inhibitions on COX-1 and COX-2 in anti-inflammatory assay in vitro [47], and melaxilline A (14), scandine (12), and meloscandonine (15) significantly inhibited in release of β-glucuronidase [28], suggesting these compounds may be responsible for the anti-inflammatory effect of MHTA.…”

“…research showed that about 66 alkaloids of different structures have been isolated from M. henryi so far [8,[12][13][14]19]. In this study, 15 monoterpenoid indole alkaloids were isolated and identified.…”

“…Furthermore, there is an urgent need for phytochemical investigation on bioactive ingredients of this plant to understand the chemical components of MHTA. Phytochemical research showed that about 66 alkaloids of different structures have been isolated from M. henryi so far [ 8 , 12 – 14 , 19 ]. In this study, 15 monoterpenoid indole alkaloids were isolated and identified.…”

“…In this study, 15 monoterpenoid indole alkaloids were isolated and identified. According to the structural characteristics, the compounds were classified as strychnos-type alkaloids (1-3), aspidosperma-type alkaloids (4)(5)(6)(7)(8), condylocarpan-type alkaloid (9), eburna-type alkaloids (10)(11), and quinoline-type alkaloids (12)(13)(14)(15). Previous reports on the cytotoxic activities of the compounds showed that aspidosperma-type alkaloids 4, 5, 6 and 8 had significant cytotoxic activities on human cancer cell lines, while other types of compounds have no obvious cytotoxic activity [13,19].…”

“…Among them, M. henryi is a perennial vine mainly distributed in China, Thailand, and Burma [9] and has been used as a folk medicine for the treatment of infantile meningitis and fractures [9]. Phytochemical studies have revealed that the stems, bark, leaves, and fruits of M. henryi present a series of structurally novel TIAs in the meric and dimeric forms, such as melodinines A-G [10] and V [11], melodinines X1-X4 [12] and W1-W4 [13], melohenines A and B [14], melodinhenines A-F, henrycinols A and B [15,16]. Some of them were characterized with complex polycyclic skeletons and some alkaloids have significant biological potentials, especially the cytotoxic activity [10,11,17].…”