Monoterpenoid inhibitors of NO production from Paeonia suffruticosa

Ding, Lei; Jiang, Zhihu; Liu, Yue; Chen, Lixia; Zhao, Qian; Yao, Xin‐Sheng; Zhao, Feng; Qiu, Feng

doi:10.1016/j.fitote.2012.09.008

Cited by 25 publications

(16 citation statements)

References 8 publications

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“…As a common traditional Chinese medicine, CM is believed to have effects of clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis [8]. At present, seven classes of compounds have been isolated from CM: phenols, monoterpenes, monoterpene glycosides, flavonoids, tannins, triterpenoids and others [9] [10] [11] [12]. Phenols and monoterpene glycosides are the predominant active ingredients [13] [14] [15] [16].…”

Section: Introductionmentioning

confidence: 99%

Study on the Multi-Component Quantitation of Cortex Moutan and Its Intestinal Absorption Characteristics

Ge¹,

Hou²,

Li³

et al. 2019

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Cortex Moutan (Paeonia suffruticosa Andr.) is a common traditional Chinese medicine and has been widely used in clinic for 2000 years in China. As sources for this crude drug are always mixed with other species, many cultivars on herbal market may lead to quality instability. Multi-component quantitative analysis is an efficient method to reflect chemical profiles of herb medicine and is always taken as the main method for quality evaluation. So, the aim of this work is to develop analytical method to quantify paeonol, paeoniflorin, gallic acid, oxypaeoniflorin, benzoylpaeoniflorin and paeonolide in Cortex Moutan (CM) to evaluate the chemical qualities of CM from different species or cultivars. Besides, we also study the intestinal absorption characteristics of paeonol and paeoniflorin for further pharmacological evaluation. In the present study, all of the standard markers were performed on an Ecosil C 18 (250 mm × 4.6 mm, 5 μM, Lubex Co., Guangzhou, China) with linear gradient elution of 0.2% formic acid water and acetonitrile. The proposed method was applied to analyze 50 batches of samples with acceptable linearity (R 2 , 0.9995-0.9999), precisions (RSD, 0.47%-2.08%), repeatability (RSD, 039%-2.63%), stability (RSD, 0.52%-2.45%), and recovery (RSD, 0.72%-3.03%) of the six compounds. Furthermore, the Hierarchical Cluster Analysis was applied to classify the 50 samples based on contents of the six compound markers. The results obtained from multi-component quantification of CM clearly indicated that CM originated from P. suffruticosa and P. ostii presented different chemical properties, and that samples from the two materials could be gathered into one branch, respectively, while CM sourced from cultivars of P. suffruticosa showed great variety on chemical quality. The results from Hierarchical Cluster Analysis implied that the established method could be used as a powerful tool for the quality evaluation of CM.

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Section: Introductionmentioning

confidence: 99%

Study on the Multi-Component Quantitation of Cortex Moutan and Its Intestinal Absorption Characteristics

Ge¹,

Hou²,

Li³

et al. 2019

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“…Therefore, mechanical milling can greatly decrease the activation energy and increase the reaction rate of the reactants. Using this technique, refractory materials such as TiN [19], ZrN [20] and HfN [21] have been successfully prepared. In the present work, mechanical milling was used for producing platinum nanoparticals and amorphous BN (a-BN) powders, which are benefit for Pt react with B atoms of a-BN to form PtB in the DC arc discharge system.…”

Section: Resultsmentioning

confidence: 99%

Platinum boride nanowires: Synthesis and characterization

Ding¹,

Qiu²,

Zhang³

et al. 2012

Journal of Alloys and Compounds

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“…e roots of P. arillata have anti-inflammatory effect, but its active components are not clear. Here, by measuring the amount of inhibition of LPSinduced NO production in RAW 264.7 mouse macrophages, 7 out of 12 compounds were selected for primary screening of anti-inflammatory components [15,18].…”

Section: Biological Activity Assaysmentioning

confidence: 99%

“…For this, the Griess reagent kit was used to determine the level of NO which was secreted by macrophage cells, and 7 isolated compounds (1, 2, 4, 5, 7, 8, and 10) which did not exhibit cytotoxic activity on LPS-induced RAW 264.7 mouse macrophages were screened for anti-in ammatory activity with the LPS group as control. Meanwhile, dexamethasone sodium phosphate (C 22 H 28 FNa 2 O 8 P) was taken as the positive control group [18]. Compared with the positive control group and negative control group, the results ( Figure 5) indicated that three compounds (1, 2, and 7) had signi cant anti-in ammatory activity and 5 had anti-in ammatory activity at the highest concentration, while the other three compounds (4, 8, and 10) without anti-in ammatory activity.…”

Section: Anti-in Ammatory Activity Assaymentioning

confidence: 99%

Chemical Constituents from the Roots of Polygala arillata and Their Anti-Inflammatory Activities

Xiang

Zhang

et al. 2019

Journal of Chemistry

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A new compound, named arillatanoside E, which was elucidated as 3-O-β-D-glucopyranosyl presenegenin 28-O-β-D-xylopyranosyl-(1 ⟶ 3)-β-D-xylopyranosyl-(1 ⟶ 4)-α-L-rhamnopyranosyl-(1 ⟶ 2)-(4-O-acetyl)-β-D-fucopyranosyl ester, along with 11 known compounds was isolated from the ethanolic extract of the roots of Polygala arillata. The 11 known compounds were identified as oleanolic acid (2), 3′-E-3,4,5-trimethoxy cinnamoyl-6-benzoyl sucrose (3), trans-ferulic acid (4), trans-feruloyl-glucoside (5), feruloyl-glucoside (6), 2,4,6-trimethoxy-1-O-β-D-glycoside (7), 3-methoxy-4-hydroxybenzoic acid (8), monopentadecanoin (9), sinapic acid (10), p-hydroxybenzaldehyde (11), and palmitic acid (12). Among them, seven isolated compounds 1, 2, 4, 5, 7, 8, and 10 exhibited little cytotoxic activity on macrophage RAW 264.7 cells. Then, the inhibitory effects of 7 isolates on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated. As a result, 3 compounds have significant anti-inflammatory activity, and they were arillatanoside E (1), oleanolic acid (2), and 2,4,6-trimethoxy-1-O-β-D-glycoside (7).

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Monoterpenoid inhibitors of NO production from Paeonia suffruticosa

Cited by 25 publications

References 8 publications

Study on the Multi-Component Quantitation of Cortex Moutan and Its Intestinal Absorption Characteristics

Study on the Multi-Component Quantitation of Cortex Moutan and Its Intestinal Absorption Characteristics

Platinum boride nanowires: Synthesis and characterization

Chemical Constituents from the Roots of Polygala arillata and Their Anti-Inflammatory Activities

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