Monte Carlo Simulation in Internal Radiotherapy of Thyroid Cancer

Oktajianto, Hammam; Setiawati, Evi

doi:10.29121/ijetmr.v5.i2.2018.669

Cited by 4 publications

(11 citation statements)

References 2 publications

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“…Monte Carlo method to calculate the absorbed dose and the absorbed dose per administrated activities for internal organs and body tissues for thyroid cancer patient such as Oktajianto H, Setiawati E, 2016 [2], and Azghadi EH., Motavalli LR, Hakimabad HM., 2014 [9].…”

Section: Similar Published Literatures Have Usedmentioning

confidence: 99%

“…However, Well Differentiated Thyroid Cancer (WDTC) patients are exposed to high levels of gamma ()irradiation during radiotheranostic procedures, thus estimating the internal doses are of high priority in order to put limitation of the dose delivered to the patients and prescribe safe 131 I activities. As the thyroid gland is the target organ for 131 I in the form of sodium iodide (NaI) solution, the thyroid gland and its surrounding organs such as brain, lung, heart wall, cervical vertebra and salivary glands are of higher risk than other organs [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…MCNP5 is a general-purpose radiation particle transport code for modeling the interaction of radiation with materials with powerful three-dimensional geometry and source modeling capabilities that can be applied in medical physics to predict internal absorbed dose in several organs. The use of MCNP with knowledge of patient anatomy will result in a significant improvement in the accuracy of dose calculations [2,15].…”

Section: Introductionmentioning

confidence: 99%

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Monte Carlo Method Estimates for Internal Dosimetry of Well Differentiated Thyroid Cancer Patients

Emad-ELDIN¹,

Kany

Massoud³

et al. 2021

Al-Azhar Bulletin of Science

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During radiotheranostic procedures, radioiodine-131( 131 I)activities deliver high internal gamma (ɣ) doses to the patient's organs. Thus, studying the internaldoses of patients is highly required to predict the stochastic or deterministiceffect of gamma radiation that may occur to patients.The objective ofthis study is to calculatethe internal doses for 11 critical organs or body tissues insideWell Differentiated Thyroid Cancer (WDTC) patients' bodiesafter receiving diagnostic and therapeutic 131 I activitiesorally during 6days post administration.Internal effective doses delivered tocritical organs are estimated mathematically using Monte Carlo simulation model in which the actual geometry, volume, mass of organs and the source localization wasdesigned based onthe patients' CT images and Oak Ridge National Laboratory (ORNL) phantom.Thus, an average sized human phantom was constructed using MCNP5in whichtwo 131 I sources were distributed in the abdominal and the thyroid gland sections.No significant radiation effect is expected during diagnostic procedures for the investigated organs including the thyroid itself. However,some deterministic effects or induction of thyroid cancer might be observedfor patients undergoing postoperative radiotherapy with largeprescribed activities.

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Section: Similar Published Literatures Have Usedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Monte Carlo Method Estimates for Internal Dosimetry of Well Differentiated Thyroid Cancer Patients

Emad-ELDIN¹,

Kany

Massoud³

et al. 2021

Al-Azhar Bulletin of Science

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“…Monte Carlo N-Particle (MCNP) is one of the computer simulation programs to simulate the process of charged particles and photons interacting with the material they are subjected to (Monte Carlo, 2000). This program is usually used to simulate the state of a nuclear reactor, but can also be used to simulate the interaction of particles with human organs (Oktajianto, 2016). MCNP can be used to accumulate doses inside organs by modeling a phantom geometry (Kristic, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Figure 5: MCNP model of phantom organ seen from the left side; Liver (1), Thymus gland (2)and Rib(3) …”

mentioning

confidence: 99%

External Radiation Simulation of Linac to Determine Effective Dose in Organs Using Monte Carlo Method

Setawati

Azam

Umiati

et al. 2020

Int. J. Eng. Tech. Mgmt. Res.

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The Linear particle accelerator (LINAC) is a tool for radiation therapy that can emit photons and electrons. Radiation of X-ray photons and LINAC electrons is obtained from the interaction of electrons fired into the target plate (tungsten). This radiation can not only affect the target organ but can also affect unwanted organs around the exposure area. Radiation irradiation effects on the organs in the exposure area can be known through simulation of LINAC and phantom radiation processes. Simulation and calculation using Monte Carlo method. This program is operated by MCNPX software. Phantom geometry uses the phantom ORNL MIRD, whereas linac geometry consists of linac blankets, tungsten plates and collimators. Radiation from linac is directed to the left lung as a target and from the simulation results of traces of radical particles shows that radiation emission from linac there are some scattering, but scattering this does not have a significant impact because the amount is not too large. Radiation effect on the organs is indicated by the effective dose quantities in which the left lung has a greater effective dose than the surrounding organs. While the right lung gets a large enough effect from other organs around the target organ. This is because the organ is located close to the target organ and has a smaller type of meeting of the other organs. Not so with the ribs, although it is the first organ exposed to radiation. Radiation that concerns the ribs has no significant effect. This is because of the enormous type of meeting. The effects of radiation on organs are not only influenced by the size of the meeting of organ types but also influenced by the weight factor.

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Determination of effective dose distribution on the target volume of cancer and organ at risk using MCNPX

Wardaya

Setiawati

Arianto

et al. 2021

J. Phys.: Conf. Ser.

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One method of therapy in cancer is Brachytherapy. which is by implanting radioactive radiation that emits gamma into the target organ. Because brachytherpy will also provide radiation doses to healthy organs around it so before doing therapy it is better to do the simulation first so that the dose received is the maximum target and the dose received by healthy organs in the vicinity (organ at risk) is minimal. The purpose of this study was to determine the distribution of the absorption dose in liver cancer with radiation source γ 103 Pd using MCNPX. In this study the target organ used was liver (liver cancer). Organs at Risk in liver cancer are the right lung, kidney and pancreas. One way to simulate this is to use Monte Carlo N Particles eXtended (MCNPX). In this study used 103Pd radioactive. the variation in the number of seeds used is from 10 to 70 seeds with an increase of 10. The 103Pd activity used is 2x10−3Ci. The results of the MCNPX simulation show that the effective dose is directly proportional to the number of seeds used. Effective doses in the liver are 0.101 to 0.699 Sv. in the right lung 0.032 to 0.229 Sv. in the kidney 0.0005 to 0.0039 Sv and in the pancreas 0.0001 to 0.0149 Sv. If in the liver the percentage of effective dose is 100%.then the distribution of effective dose percentage in the right lung is 34.67%.kidney 0.63% and pancreas 1.06%. The percentage of the effective dose distribution is relatively safe because it is still below 75%.

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Monte Carlo Simulation in Internal Radiotherapy of Thyroid Cancer

Cited by 4 publications

References 2 publications

Monte Carlo Method Estimates for Internal Dosimetry of Well Differentiated Thyroid Cancer Patients

Monte Carlo Method Estimates for Internal Dosimetry of Well Differentiated Thyroid Cancer Patients

External Radiation Simulation of Linac to Determine Effective Dose in Organs Using Monte Carlo Method

Determination of effective dose distribution on the target volume of cancer and organ at risk using MCNPX

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