Deuterium gas-puff experiments have been carried out on the GIT-12 generator at the Institute of High Current Electronics in Tomsk. The emphasis was put on the study of plasma dynamics and neutron production in double shell gas puffs. A linear mass density of deuterium (D2) varied between 50 and 85 μg/cm. Somewhat problematic was a spread of the D2 gas at a large diameter in the central anode–cathode region. The generator operated in two regimes, with and without a plasma opening switch (POS). When the POS was used, a current reached a peak of 2.7 MA with a 200 ns rise time. Without the POS, a current rise time approached 1500 ns. The influence of different current rise times on neutron production was researched. Obtained results were important for comparison of fast deuterium Z-pinches with plasma foci. Average DD neutron yields with and without the POS were about 1011. The neutron yield seems to be dependent on a peak voltage at the Z-pinch load. In all shots, the neutron emission started during stagnation. At the beginning of the neutron production, the neutron emission correlated with soft x-rays and a significant fraction of neutrons could be explained by the thermonuclear mechanism. Nevertheless, a peak of the neutron emission occurred 40 ns after a soft x-ray peak. At this very moment, hard x-rays above 1 MeV were detected and a rapid expansion with a velocity of 3×105 m/s was observed. In the case of the POS, 1 MeV widths of radial neutron spectra implied that there are deuterons with the energy above 200 keV moving in the radial direction. On the basis of D2 gas puff experiments in the 0.3–17 MA region, the neutron yield dependence on a current as Y∝I3.0±0.2 was proposed.