Monthly rifampicin, ofloxacin, and minocycline therapy for generalized and localized granuloma annulare

Garg, Shilpa; Baveja, Sukriti

doi:10.4103/0378-6323.148564

Cited by 8 publications

(6 citation statements)

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“…2 However, some also recognized that many GA were unrelated to tuberculosis, but a phenotypic clinicopathological reaction to multiple etiologic agents and various forms of therapy was found. 3 In fact, some cases of GA with chronic pulmonary tuberculosis responding to a specific anti-tuberculosis therapy were reported. 3 Resolution may be related not only to the antimicrobial effects of the anti-tubercular drugs but also to an immunological stimulation, especially of rifampin, on cellular immune response.…”

Section: Discussionmentioning

confidence: 99%

“…3 In fact, some cases of GA with chronic pulmonary tuberculosis responding to a specific anti-tuberculosis therapy were reported. 3 Resolution may be related not only to the antimicrobial effects of the anti-tubercular drugs but also to an immunological stimulation, especially of rifampin, on cellular immune response. 3 In our case, the patient himself feel apparently relief from lesions after anti-tuberculosis treatment and stop recovery since stopping taking the medicine.…”

Section: Discussionmentioning

confidence: 99%

“…3 Resolution may be related not only to the antimicrobial effects of the anti-tubercular drugs but also to an immunological stimulation, especially of rifampin, on cellular immune response. 3 In our case, the patient himself feel apparently relief from lesions after anti-tuberculosis treatment and stop recovery since stopping taking the medicine. Furthermore, it is worth noting that tuberculids, generalized exanthems in the skin of tuberculous patients possibly resulting from hypersensitivity reactions to the tubercle bacillus, may mimic GA. 2 Histologically, a palisading or interstitial pattern of granulomatous inflammation attached mucin can represent the main pathological changes in all subtypes of GA, the latter one being more common but different to discern.…”

Section: Discussionmentioning

confidence: 99%

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Annulare With Tuberculosis and Cutis Laxa: A Rare Case Report

Wang¹,

Geng²,

Xu³

2019

International Journal of Dermatology and Venereology

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Introduction: Granuloma annulare (GA) is a benign, noninfectious granulomatous disorder of unknown etiology, characterized by an annular arrangement of erythematous small nodules and plaques, classically localized on dorsal surfaces of the hands and feet. GA shows palisading granulomas with a central zone of necrobiotic collagen and mucin deposition surrounded by a palisade of histiocytes. Here, we reported a 24-year-old man with GA combined with tuberculosis and cutis laxa. Case presentation: A 24-year-old man was presented with skin annular lesions on the trunk and extremities without subjective symptoms for three years. The annular lesions first arose in the trunk that slowly progressed to most parts of the body and cutis laxa-like lesions appeared on the left inguinal region with inguinal hernia two years ago. At the same time, the patient was diagnosed with pulmonary tuberculosis due to the hemoptysis for two years and the sputum culture for tuberculosis bacillus was positive. He was treated with triple anti-tuberculosis drugs regularly. Partial remission of the skin lesions was noted since then. Pathological examination showed similar histological changes in the interstitial pattern of GA. Discussion: Tuberculosis was a possible etiologic factor in GA because of the coincidental occurrence, granulomatous histologic features, and positive tuberculin skin tests. In fact, some cases of GA with chronic pulmonary tuberculosis responding to a specific anti-tuberculosis therapy were reported. It is worth noting that tuberculids, generalized exanthems in the skin of tuberculous patients possibly resulting from hypersensitivity reactions to the tubercle bacillus, may mimic GA. Furthermore, our patient also showed extremely characteristic slack skin in posterior lumbar and groin, which was deemed to be related to reduction and destruction of elastic fibers. Conclusion: Generalized interstitial GA with tuberculosis and cutis laxa is vary rare, which is worth being aware of the possibility of such a occurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Annulare With Tuberculosis and Cutis Laxa: A Rare Case Report

Wang¹,

Geng²,

Xu³

2019

International Journal of Dermatology and Venereology

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“…The response of GA to rifampin-based combinations has implications for HS, which is sometimes a granulomatous disease [45,46]. Rifampin might help break down the granulomas of HS and aid in the treatment of HS via this anti-granuloma effect.…”

Section: Rifampin As a Treatment For Inflammatory Skin Disease-granulomatousmentioning

confidence: 99%

Why rifampin (rifampicin) is a key component in the antibiotic treatment of hidradenitis suppurativa: a review of rifampin's effects on bacteria, bacterial biofilms, and the human immune system

Scheinfeld¹

2016

Dermatology Online Journal

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“…Examples of therapeutic options which have been reported include high-potency topical or systemic corticosteroids, immunosuppressants, and antibiotics. Various antibiotics have been proposed as potential therapy for GGA, the most recent being combination therapy with rifampicin, ofloxacin and minocycline (ROM) (Garg and Baveja, 2015) . This article aims to explore the use of antibiotics in treating GGA with focus on the paediatric GA sub-group.…”

Section: Introductionmentioning

confidence: 99%

Are Antibiotics of Any Use in the Management of Granuloma Annulare in Children?

Chia

Ahmed

Oligbu

et al. 2019

AJID

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Background: Granuloma annulare (GA) is a benign inflammatory dermatosis of unknown cause, of which generalised granuloma annulare (GGA) is a subtype that tends to be resistant to treatment. Various antibiotics have been used to treat GGA, the most recent being combination therapy with rifampicin, ofloxacin and minocycline (ROM). This study aims to explore the efficacy of antibiotics in treating GGA, and whether antibiotics may be useful in children with GGA. Materials and Methods: A systematic review of literature published from 1947 to 2017 was undertaken in order to evaluate the use of antibiotics in treating GGA. Data on characteristics of children with GGA were extracted and eligible studies were then qualitatively analysed. Results: Seven hundred and ninety (790) potential studies were identified, of which 16 were eligible for inclusion in the final analysis. Of these 16 studies, majority were case studies (n=9, 56.3%), with 2 case series (12.5%), 2 retrospective studies (12.5%) and 3 open-label prospective studies (18.8%). Main antibiotic treatments reported were either monthly combination therapy of rifampicin, ofloxacin and minocycline (ROM), or monotherapy with dapsone or doxycycline. Out of a total of 158 patients with GA, 72 patients (45.6%) were treated with antibiotics. Of the 72, 48.6% (n=35) of these patients had GGA while 4 were children; two with GA (2 with GGA), all of whom were treated with dapsone. Conclusion: There is paucity of evidence to support the use of antibiotics in the treatment of GGA in children. Although ROM has shown promising results in adults, more studies are needed to validate these findings in children.

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Monthly rifampicin, ofloxacin, and minocycline therapy for generalized and localized granuloma annulare

Cited by 8 publications

References 8 publications

Annulare With Tuberculosis and Cutis Laxa: A Rare Case Report

Annulare With Tuberculosis and Cutis Laxa: A Rare Case Report

Why rifampin (rifampicin) is a key component in the antibiotic treatment of hidradenitis suppurativa: a review of rifampin's effects on bacteria, bacterial biofilms, and the human immune system

Are Antibiotics of Any Use in the Management of Granuloma Annulare in Children?

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