Montmorillonite nanoclay as a multifaceted drug-delivery carrier: A review

Sarvaiya, Jayrajsinh; Shankar, Gauri; Agrawal, Y. K.; Bakre, Lateef Gbenga

doi:10.1016/j.jddst.2017.03.023

Cited by 240 publications

(118 citation statements)

References 104 publications

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“…[ 88 ] Among the mechanisms to describe drug release from nanocomposites, the tortuous pathway model is the most appropriate one ( Figure a). [ 13,40,69,81b ] Compared to other morphologies like micelles, capsules, nanogels, vesicles, etc., the films are more stable (mechanically and chemically), which supports the release of the drug for a longer time. Chung et al [ 69 ] studied the relationship between various organically modified clays using dodecylamine‐MMT and hexadecylamine‐MMT reinforced polyurethane copolymer films.…”

Section: Biomedical Applications Of Copolymer/clay Nanocompositesmentioning

confidence: 99%

“…[ 12 ] Clay reinforcements of copolymers can enrich various further characteristics such as antimicrobial properties, shape recovery, conductivity (electrical and thermal), targeted delivery of biomolecules or drugs, compatibility with blood and living tissue/organs and biodegradability. [ 13 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 17 ] Concerning biomedical applications, [ 18 ] the increment in the gallery space of nanoclays is highly beneficial, especially in drug delivery materials. [ 13 ] More space between the clay layers allows for a higher loading efficiency.…”

Section: Introductionmentioning

confidence: 99%

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Copolymer/Clay Nanocomposites for Biomedical Applications

Murugesan

Scheibel

2020

Adv Funct Materials

154

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Nanoclays still hold a great strength in biomedical nanotechnology applications due to their exceptional properties despite the development of several new nanostructured materials. This article reviews the recent advances in copolymer/clay nanocomposites with a focus on health care applications. In general, the structure of clay comprises aluminosilicate layers separated by a few nanometers. Recently, nanoclay-incorporated copolymers have attracted the interest of both researchers and industry due to their phenomenal properties such as barrier function, stiffness, thermal/flame resistance, superhydrophobicity, biocompatibility, stimuli responsiveness, sustained drug release, resistance to hydrolysis, outstanding dynamic mechanical properties including resilience and low temperature flexibility, excellent hydrolytic stability, and antimicrobial properties. Surface modification of nanoclays provides additional properties due to improved adhesion between the polymer matrix and the nanoclay, high surface free energy, a high degree of intercalation, or exfoliated morphology. The architecture of the copolymer/clay nanocomposites has great impact on biomedical applications, too, by providing various cues especially in drug delivery systems and regenerative medicine.

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Section: Biomedical Applications Of Copolymer/clay Nanocompositesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Copolymer/Clay Nanocomposites for Biomedical Applications

Murugesan

Scheibel

2020

Adv Funct Materials

154

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“…Nanocomposites based on polymer and clay are advanced materials for the development of controlled drug delivery systems due to their versatile properties such as (1) high drug encapsulation efficiency, (2) enhanced stability of API against pH variation and enzyme action, (3) low burst release of the drug, and (4) a controlled and targeted drug release profile [16][17][18]. In general, nanocomposites are dispersions of two or more components at the nanometric scale with optimized properties compared to the pure materials, which can be obtained by dispersing clay layers or sheets into a polymeric matrix [19,20].…”

Section: Introductionmentioning

confidence: 99%

Clay-Polymer Nanocomposites Prepared by Reactive Melt Extrusion for Sustained Drug Release

Liu¹,

et al. 2020

Pharmaceutics

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Clay–polymer nanocomposites have exhibited a great potential as carriers for controlled release drug delivery. This study aims to prepare exfoliated montmorillonite–Eudragit RS nanocomposites using reactive melt extrusion and investigate the influence of claying loading, clay types (sodium montmorillonite (Cloisite Na) vs. organomodified montmorillonite (Cloisite 20)) on clay–polymer interactions and drug release properties. The clays were used as the filler material at various levels in Eudragit RS and theophylline was used as the active pharmaceutical ingredient. The resulting structure of the nanocomposites was characterized using TEM (transmission electron microscopy) and XRPD (X-ray powder diffraction). The hygroscopicity of the nanocomposites was investigated using DVS (dynamic vapor sorption). The effect of the interfacial interaction between the polymer and clay sheet, the clay loading as well as the clay type on the drug release behavior were further studied by dissolution testing. TEM and XRPD data show that when the clay content is increased from 5% to 15% by weight, the nanocomposite’s structure switches from a fully exfoliated state to intercalated structures or partial exfoliation with stacked clay layers. FT-IR (fourier transform infrared spectroscopy) and ssNMR (solid-state NMR) results suggest that Cloisite Na and Cloisite 20 layers exhibit different interaction strengths with polymer networks by creating compacted complex structures. The addition of nanoclay in the formulation could robustly adjust drug release profiles, and the clay concentration and type are important factors that affect the crossing-linking density of the nanocomposites by adjusting the drug release properties. This study indicates that the clay–Eudragit RS nanocomposites provide an improved oral controlled drug delivery system that minimizes the drug dosing frequency, potentially leading to improved patient compliance.

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“…As a whole, the boundaries and advantages of using nanocarriers for transdermal DDS depends on their size, composition, surface charge, etc. Thus far, numerous active ingredients (including drugs) have been effectively intercalated into anionic and cationic clay hosts for controlled release properties, showing that clays are potential nanocarriers for the treatment of many diseases and alleviating skin problems ,. Amongst inorganic (cationic and anionic) clay minerals as nanocarriers, the anionic layered double hydroxide is promising material for various innovative topical applications.…”

Section: Introductionmentioning

confidence: 99%

Layered Double Hydroxide‐Based Functional Nanohybrids as Controlled Release Carriers of Pharmaceutically Active Ingredients

Ray

Mosangi

Pillai

2018

The Chemical Record

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The chemical stability, degradation and penetration ability of pharmaceutically active ingredients in topical formulations are the greatest challenges because of problems with the protection of actives for long times and with delivery. Therefore, the development of unique and efficient substrate material is vital for their protection and controlled drug release. Layered double hydroxides (LDHs) known as hydrotalcite like compounds possess positive charges due to isomorphic substitutions, which are counterbalanced by hydrated exchangeable anions located in the interlayer region. Some of the active ingredient molecules can be intercalated into the inner region of the LDHs through ionic bonding, hydrogen bonding or van der Waals interaction to form nanohybrids, which are more potent for their protection and controlled-release. This account focuses on our recent research efforts and key scientific and technical challenges in the development of LDH based nanohybrids for commercial use in advanced controlled release carriers of active ingredients in topical formulations.

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Montmorillonite nanoclay as a multifaceted drug-delivery carrier: A review

Cited by 240 publications

References 104 publications

Copolymer/Clay Nanocomposites for Biomedical Applications

Copolymer/Clay Nanocomposites for Biomedical Applications

Clay-Polymer Nanocomposites Prepared by Reactive Melt Extrusion for Sustained Drug Release

Layered Double Hydroxide‐Based Functional Nanohybrids as Controlled Release Carriers of Pharmaceutically Active Ingredients

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