Montmorillonite nanosheets with enhanced photodynamic performance for synergistic bacterial ablation

Pan, Yufeng; Gao, Yuting; Hu, Jian; Ye, Guangyu; Zhou, Feng; Yan, Chunjie

doi:10.1039/d0tb02254c

Cited by 19 publications

(14 citation statements)

References 34 publications

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“…Montmorillonite (MMT) is a major ingredient of bentonite and is approved by the Food and Drug Administration of the United States (FDA) for medical use [15,16]. MMT can act as a filler in a polymeric matrix, and this has attracted the attention of scientists especially for the enhancement of the thermal and mechanical properties of native polymers [17,18].…”

Section: Introductionmentioning

confidence: 99%

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

et al. 2021

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Bone-related diseases have been increasing worldwide, and several nanocomposites have been used to treat them. Among several nanocomposites, polyhydroxybutyrate (PHB)-based nanocomposites are widely used in drug delivery and tissue engineering due to their excellent biocompatibility and biodegradability. However, PHB use in bone tissue engineering is limited due to its inadequate physicochemical and mechanical properties. In the present work, we synthesized PHB-based nanocomposites using a nanoblend and nano-clay with modified montmorillonite (MMT) as a filler. MMT was modified using trimethyl stearyl ammonium (TMSA). Nanoblend and nano-clay were fabricated using the solvent-casting technique. Inspection of the composite structure revealed that the basal spacing of the polymeric matrix material was significantly altered depending on the loading percentage of organically modified montmorillonite (OMMT) nano-clay. The PHB/OMMT nanocomposite displayed enhanced thermal stability and upper working temperature upon heating as compared to the pristine polymer. The dispersed (OMMT) nano-clay assisted in the formation of pores on the surface of the polymer. The pore size was proportional to the weight percentage of OMMT. Further morphological analysis of these blends was carried out through FESEM. The obtained nanocomposites exhibited augmented properties over neat PHB and could have an abundance of applications in the industry and medicinal sectors. In particular, improved porosity, non-immunogenic nature, and strong biocompatibility suggest their effective application in bone tissue engineering. Thus, PHB/OMMT nanocomposites are a promising candidate for 3D organ printing, lab-on-a-chip scaffold engineering, and bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

et al. 2021

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“…According to the IUPAC classification, MMT and TPCI/MMT presented a type IV adsorption branch with H3-type hysteresis loops, belonging to multimolecular layer adsorption. These characteristics were corresponding to the layered structure of MMT and TPCI/MMT, which were caused by slit shaped pores between parallel layers . The larger specific surface area of TPCI/MMT was conducive to bacteria attraction, which could facilitate the further bacteria elimination. , …”

Section: Results and Discussionmentioning

confidence: 97%

“…Montmorillonite (MMT), a natural aluminomagnesium silicate clay, has attracted considerable attention due to its extensive application in biomedical areas, such as intestinal ailments, drug delivery, − and additive manufacturing. , MMT is composed of a three-layered lamellar structure with aluminum oxide octahedra in the middle and silicon oxygen tetrahedra on the top and bottom sides. , The highly ordered lattice arrangement and compact packing of tetrahedron and octahedron structures endow MMT characteristics of high cation exchange capacity and large surface area with excellent adsorption and drug loading properties. , Although some studies have revealed that MMT can adsorb bacteria and bacterial enterotoxins when taken as anti-inflammatory medicine, the antibacterial effect of MMT itself in vitro is actually weak. , …”

Section: Introductionmentioning

confidence: 99%

AIEgen Intercalated Nanoclay-Based Photodynamic/Chemodynamic Theranostic Platform for Ultra-Efficient Bacterial Eradication and Fast Wound Healing

Zhang

Zhou

et al. 2022

ACS Appl. Mater. Interfaces

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With the emergence and global spread of bacterial resistance, pathogenic bacterial infections have become a serious threat to human health. Thus, therapeutic strategies with highly antibacterial efficacy and a low tendency to induce drug resistance are strongly desired to combat bacterial infections. Here, an ultra-efficient photodynamic/chemodynamic theranostics platform is developed by intercalating an aggregation-induced emission (AIE) photosensitizer, TPCI, into the nanolayers of iron-bearing montmorillonite (MMT). The formed TPCI/MMT composite can not only perform efficient photodynamic therapy (PDT) through a burst generation of singlet oxygen (1O2) upon white light illumination but also continuously implement chemodynamic therapy (CDT) by converting endogenous hydrogen peroxide into highly toxic hydroxyl radicals (•OH) due to iron release. In addition, the fluorescence of TPCI/MMT can be activated due to the AIE feature of TPCI, which helps guide the location of the antimicrobials. The combination of such powerful bombs (PDT) and unremitting ambushes (CDT) in TPCI/MMT can synergistically and effectively eliminate bacteria and promote faster wound healing in vivo with good biocompatibility and low side effects. The smart and simple design of TPCI/MMT provides a representative paradigm for achieving efficient antimicrobials to combat the coming resistance crisis.

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“…We next characterized CNC–MMT–PEG, in which MMT was utilized to enhance the dispersibility and biocompatibility of CNC. MMT is a highly dispersive 2D layered aluminosilicate filled with various cations, including Fe 3+ (3.31 wt %), in its interlayered space . Possessing a large surface area, layered MMT could easily load 2D CNC to form interesting 2D carbon–2D clay nanohybrids.…”

Section: Resultsmentioning

confidence: 99%

Near-Infrared-II Activatable Symbiotic 2D Carbon–Clay Nanohybrids for Dual Imaging-Guided Combinational Cancer Therapy

Yin

Tong

Meng

et al. 2022

ACS Appl. Mater. Interfaces

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Two-dimensional (2D) nanomaterials hold great potential for cancer theranostic applications, yet their clinical translation faces great challenges of high toxicity and limited therapeutic/diagnostic modality. Here, we have created a kind of symbiotic 2D carbon−2D clay nanohybrids, which are composed of a novel 2D carbon nanomaterial (carbon nanochips, or CNC), prepared by carbonizing a conjugated polymer polydiiodobutadiyne, and a 2D layered aluminosilicate clay mineral montmorillonite (MMT). Intriguingly, with the formation of the nanohybrids, MMT can help the dispersion of CNC, while CNC can significantly reduce the hemolysis and toxicity of MMT. The symbiotic combination of CNC and MMT also leads to a synergistic anti-cancer theranostic effect. CNC has a strong absorption and high photothermal conversion efficiency in the second near-infrared region (NIR-II, 1000−1700 nm), while MMT contains Fe 3+ that can facilitate the generation of reactive oxygen species from highly expressed H 2 O 2 in tumor microenvironment. The nanohybrids not only enable a synergy of photothermal therapy and chemodynamic therapy to suppress the extremely rapid growth of RM1 tumors in mice but also allow for dual photoacoustic and magnetic imaging to guide the drug delivery and NIR-II irradiation execution, hence establishing a highly efficient and biosafe "all-in-one" theranostic platform for precision nanomedicine.

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Montmorillonite nanosheets with enhanced photodynamic performance for synergistic bacterial ablation

Abstract: Montmorillonite (MMT), as a naturally sourced and FDA-approved biomaterial, has attracted considerable attention due to its extensive application in biomedical area, such as intestinal aliments, drug delivery, and additive manufacturing....

Cited by 19 publications

References 34 publications

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

AIEgen Intercalated Nanoclay-Based Photodynamic/Chemodynamic Theranostic Platform for Ultra-Efficient Bacterial Eradication and Fast Wound Healing

Near-Infrared-II Activatable Symbiotic 2D Carbon–Clay Nanohybrids for Dual Imaging-Guided Combinational Cancer Therapy

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