Mood Disorders and Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis in Multiple Sclerosis

Faßbender, Klaus; Schmidt, Roland; Mößner, Reinald; Kischka, Udo; Kühnen, J.; Schwartz, Andreas; Hennerici, Michael G.

doi:10.1001/archneur.55.1.66

Cited by 197 publications

(125 citation statements)

References 40 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…[44] Failure to respond to dexamethasone challenge has also been associated with the presence of gadolinium enhancing lesions on MRI in MS patients, suggesting that some of the depressive symptomatology in MS could be related to disease activity. [45] …”

Section: Neurobiology Of Depression In Msmentioning

confidence: 99%

Psychiatric Issues in Multiple Sclerosis

Chwastiak

Ehde

2007

Psychiatric Clinics of North America

140

View full text Add to dashboard Cite

Section: Neurobiology Of Depression In Msmentioning

confidence: 99%

Psychiatric Issues in Multiple Sclerosis

Chwastiak

Ehde

2007

Psychiatric Clinics of North America

140

View full text Add to dashboard Cite

“…Second, cerebral involvement is more closely related to depression in multiple sclerosis than is spinal cord involvement 10 . Third, depression in multiple sclerosis is unrelated to neurological status (i.e., disease duration, course, and severity of disability), and to degree of cognitive impairment 11 . Mania and euphoria Epidemiological studies have found that multiple sclerosis patients are twice as likely as healthy controls to have bipolar disorder.…”

Section: Mood Disordermentioning

confidence: 99%

“…Mania and euphoria Epidemiological studies have found that multiple sclerosis patients are twice as likely as healthy controls to have bipolar disorder. Some evidence supports that both disorders might have a shared genetic basis 11 . Mania might occur as part of the physical disorder or secondary to drug treatments.…”

Section: Mood Disordermentioning

confidence: 99%

See 1 more Smart Citation

Psycho-social and medical patterns of psychiatric disorders in multiple sclerosis patients, Baghdad-Iraq

2017

Iraqi J. Public Health

View full text Add to dashboard Cite

Objective: Multiple sclerosis is a common neurological disease that causes physical and psychological morbidity. Psychological disorders, especially the mood disorder, are the most common manifestation of psych. Morbidity in multiple sclerosis and the adjustment disorders is the commonest psychiatric disorder. Aim:This study aims to estimate the rate of psychiatric disorders among patients with multiple sclerosis and to know the commonest psychiatric disorders. Methods:The sample consists of 63 patients are attending a multiple sclerosis clinic in Baghdad Teaching Hospital in Medical City. Diagnostic statistical of mental health disorder-version V (DSM-V) criteria, general health questionnaire (GHQ) and socio demographic data were used for the diagnosis. Results:The results showed that 63 patients have mental disorders. There is a significant relationship between mental disorders and patients who use the treatment of interferon 22.64% of the total number of patient samples with suicidal ideas. Conclusions:Multiple sclerosis is a common neurological disease. The mental state of patients with multiple sclerosis may be affected by the disease sequel and/or its drug treatment producing variable clinical manifestations. In this study, significant correlations between socio-demographic characteristics and psychiatric disorders in multiple sclerosis, adjustment disorders are the most common psychiatric disorder in multiple sclerosis. The psychiatric disorders were higher in women than in men. There is a significant relation between psychiatric disorders and patients' treatment with Rebif B-interferon high percentage (23.809%) of patients have suicidal ideations most of them suffer from major depressive disorder (MDD).

show abstract

“…Ysrraelit et al, 2008) are also observed in MS. Furthermore, there is evidence that during the early stages of the disease, neuroendocrine-limbic abnormalities may be specific for MS patients who exhibit depressive symptoms (Fassbender et al, 1998;Gold et al, 2010Gold et al, , 2011Kern et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Decreased hydrocortisone sensitivity of T cell function in multiple sclerosis-associated major depression

Fischer

Otte

Krieger

et al. 2012

Psychoneuroendocrinology

View full text Add to dashboard Cite

Summary Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the CNS with a high prevalence of depression. Both MS and depression have been linked to elevated cortisol levels and inflammation, indicating disturbed endocrine-immune regulation. An imbalance in mineralocorticoid versus glucocorticoid signaling in the CNS has been proposed as a pathogenetic mechanism of depression. Intriguingly, both receptors are also expressed in lymphocytes, but their role for 'escape' of the immune system from endocrine control is unknown. Using steroid sensitivity of T cell function as a read-out system, we here investigate a potential role of mineralocorticoid receptor (MR) versus glucocorticoid receptor (GR) regulation in the immune system as a biological mechanism underlying MS-associated major depression. Twelve female MS patients meeting diagnostic criteria for current major depressive disorder (MDD) were compared to twelve carefully matched MS patients without depression. We performed lymphocyte phenotyping by flow cytometry. In addition, steroid sensitivity of T cell proliferation was tested using hydrocortisone as well as MR (aldosterone) and GR (dexamethasone) agonists. Sensitivity to hydrocortisone was decreased in T cells from depressed MS patients. Experiments with agonists suggested disturbed MR regulation, but intact GR function. Importantly, there were no differences in lymphocyte composition and frequency of T cell subsets, indicating that the differences in steroid sensitivity are unlikely to be secondary to shifts in the immune compartment. To our knowledge, this study provides first evidence for altered steroid sensitivity of T cells from MS patients with comorbid MDD possibly due to MR dysregulation.

show abstract

Mood Disorders and Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis in Multiple Sclerosis

Abstract: Affective and neuroendocrine disorders were related to inflammatory disease activity but not to degree of disability, supporting the hypothesis that these symptoms are causally associated with brain injury.

Cited by 197 publications

References 40 publications

Psychiatric Issues in Multiple Sclerosis

Psychiatric Issues in Multiple Sclerosis

Psycho-social and medical patterns of psychiatric disorders in multiple sclerosis patients, Baghdad-Iraq

Decreased hydrocortisone sensitivity of T cell function in multiple sclerosis-associated major depression

Contact Info

Product

Resources

About