Mood instability and functional recovery in bipolar disorders

Strejilevich, Sergio; Martino, Diego Javier; Murru, Andréa; Teitelbaum, Julia; Fassi, Guillermo; Marengo, Eliana; Igoa, Ana; Colom, Francesc

doi:10.1111/acps.12065

Cited by 128 publications

(135 citation statements)

References 46 publications

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“…It has previously been suggested that affective instability may be a core dimension of bipolar disorder, with levels being high in euthymia in comparison to controls and existing independent of manic or depressive episodes (Strejilevich et al, 2013).…”

Section: Theoretical and Clinical Implicationsmentioning

confidence: 99%

“…Whilst affective instability is transdiagnostic (Broome et al, 2015b) our findings add further support to the idea that affective instability may be a particularly important psychopathology in bipolar disorder. It may underlie some of the severe consequences of the illness, predicting chronicity and severity in youth with the disorder (Yen et al, 2015) and functional losses in those with established illness (Strejilevich et al, 2013).…”

Section: Theoretical and Clinical Implicationsmentioning

confidence: 99%

“…Thirdly, greater affective lability and intensity during the inter-episode period prospectively explains impairment in home and work functioning over 1 month (Gershon and Eidelman, 2015) and longer term disability levels in bipolar disorder (Strejilevich et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Affective instability, childhood trauma and major affective disorders

Marwaha

Gordon‐Smith

Broome

et al. 2016

Journal of Affective Disorders

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Section: Theoretical and Clinical Implicationsmentioning

confidence: 99%

Section: Theoretical and Clinical Implicationsmentioning

confidence: 99%

See 1 more Smart Citation

Affective instability, childhood trauma and major affective disorders

Marwaha

Gordon‐Smith

Broome

et al. 2016

Journal of Affective Disorders

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“…7 Presence of depressive symptoms is associated with worse outcomes. 8 Cognitive impairments in BD are consistently observed during mood episodes. [9][10][11][12] However, they can also be identified during euthymia.…”

Section: Introductionmentioning

confidence: 99%

Cognition and functioning in bipolar depression

Kapczinski

Narvaez

Magalhães

et al. 2016

Rev. Bras. Psiquiatr.

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Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test. Results: In patients, severe depression was associated with poorer cognitive performance on measures of executive function. Patients with severe depression showed worse global functioning than those with moderate depression (z = 2.54, p = 0.011). In patients with severe depression, lower global functioning was associated with lower scores in working memory (r = -0.200, p = 0.010), and executive function (r = -0.210, p = 0.007; and r = 0.293, p o 0.001). Conclusion: Our findings suggest cognitive impairment and global functioning impairment are associated with the severity of depressive symptoms in bipolar depression. Intensive treatment of depressive symptoms in patients with BD is crucial to improve cognitive functioning and, consequently, functional outcomes.

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“…Mood instability and interpersonal sensitivity are typical characteristics of BD [1][2][3][4] . In comparison to other mood and anxiety disorders, patients with BD suffer from a greater severity of disability [5] .…”

Section: Introductionmentioning

confidence: 99%

Autobiographical Memory in Bipolar Disorder and Its Link to Neuropsychological Functioning

Quinlivan

Dallacker

Renneberg³

et al. 2017

Psychopathology

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Objective: The aim of this study was to examine the specificity of autobiographical memory (AM) in bipolar disorder (BD) and to investigate the association between AM and neuropsychological functions. Method: Twenty bipolar patients and 22 matched healthy controls (HCs) were included in this study. AM was assessed with an extended version of the Autobiographical Memory Test (AMT) including rejection cue words. A neuropsychological test battery was used to examine verbal memory, executive functions, and attention. Results: Across both groups, the number of specific memories in the AMT was significantly smaller in response to rejection cue words and positive cue words than in response to negative cue words. Participants with BD and HCs did not differ significantly in neuropsychological measures. Across both groups, scores of verbal memory, executive functions, and attention were significantly correlated with specificity of retrieved memories. Limitations: Although our clinical sample consisted of clinically stable outpatients, 6 out of 20 patients were not rated as euthymic but as mildly depressed. All BD patients were medicated. Conclusion: Contrary to previous results, patients with BD did not differ in the number of specific memories compared to an HC group. Our findings suggest that neuropsychological functioning is associated with AMT specificity. Further research is required to gain a better understanding of the underlying mechanisms which may influence the ease of memory retrieval.

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Mood instability and functional recovery in bipolar disorders

Abstract: New methodologies including subsyndromal symptoms and mood instability parameters might contribute to understand the worse long-term functional outcome that affects a considerable percentage of BD patients even after episode remission. Concerns about therapeutic approaches are discussed.

Cited by 128 publications

References 46 publications

Affective instability, childhood trauma and major affective disorders

Affective instability, childhood trauma and major affective disorders

Cognition and functioning in bipolar depression

Autobiographical Memory in Bipolar Disorder and Its Link to Neuropsychological Functioning

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